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Items: 1 to 20 of 249


Structural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancer.

Chen C, Gu P, Wu J, Chen X, Niu S, Sun H, Wu L, Li N, Peng J, Shi S, Fan C, Huang M, Wong CC, Gong Q, Kumar-Sinha C, Zhang R, Pusztai L, Rai R, Chang S, Lei M.

Nat Commun. 2017 Apr 10;8:14929. doi: 10.1038/ncomms14929.


Extensive telomere erosion is consistent with localised clonal expansions in Barrett's metaplasia.

Letsolo BT, Jones RE, Rowson J, Grimstead JW, Keith WN, Jenkins GJ, Baird DM.

PLoS One. 2017 Mar 31;12(3):e0174833. doi: 10.1371/journal.pone.0174833. eCollection 2017.


The Role of PI3K Isoforms in Regulating Bone Marrow Microenvironment Signaling Focusing on Acute Myeloid Leukemia and Multiple Myeloma.

Piddock RE, Bowles KM, Rushworth SA.

Cancers (Basel). 2017 Mar 28;9(4). pii: E29. doi: 10.3390/cancers9040029. Review.


Dysregulation of Telomere Lengths and Telomerase Activity in Myelodysplastic Syndrome.

Park HS, Choi J, See CJ, Kim JA, Park SN, Im K, Kim SM, Lee DS, Hwang SM.

Ann Lab Med. 2017 May;37(3):195-203. doi: 10.3343/alm.2017.37.3.195.


Prediagnosis Leukocyte Telomere Length and Risk of Ovarian Cancer.

Yang M, Prescott J, Poole EM, Rice MS, Kubzansky LD, Idahl A, Lundin E, De Vivo I, Tworoger SS.

Cancer Epidemiol Biomarkers Prev. 2017 Mar;26(3):339-345. doi: 10.1158/1055-9965.EPI-16-0466. Epub 2017 Feb 16.


Telomere Length and Risk of Hepatocellular Carcinoma: A Nested Case-control Study in Taiwan Cancer Screening Program Cohort.

Zeng H, Wu HC, Wang Q, Yang HI, Chen CJ, Santella RM, Shen J.

Anticancer Res. 2017 Feb;37(2):637-644.


TGF-beta receptor mediated telomerase inhibition, telomere shortening and breast cancer cell senescence.

Cassar L, Nicholls C, Pinto AR, Chen R, Wang L, Li H, Liu JP.

Protein Cell. 2017 Jan;8(1):39-54. doi: 10.1007/s13238-016-0322-1. Epub 2016 Sep 30.


Telomerase Activation in Hematological Malignancies.

Ropio J, Merlio JP, Soares P, Chevret E.

Genes (Basel). 2016 Sep 7;7(9). pii: E61. doi: 10.3390/genes7090061. Review.


A genetic interaction between RAP1 and telomerase reveals an unanticipated role for RAP1 in telomere maintenance.

Martínez P, Gómez-López G, Pisano DG, Flores JM, Blasco MA.

Aging Cell. 2016 Sep 1. doi: 10.1111/acel.12517. [Epub ahead of print]


Telomeres and telomerase in head and neck squamous cell carcinoma: from pathogenesis to clinical implications.

Boscolo-Rizzo P, Da Mosto MC, Rampazzo E, Giunco S, Del Mistro A, Menegaldo A, Baboci L, Mantovani M, Tirelli G, De Rossi A.

Cancer Metastasis Rev. 2016 Sep;35(3):457-74. doi: 10.1007/s10555-016-9633-1. Review.


Telomere status in chronic lymphocytic leukemia with TP53 disruption.

Guièze R, Pages M, Véronèse L, Combes P, Lemal R, Gay-Bellile M, Chauvet M, Callanan M, Kwiatkowski F, Pereira B, Vago P, Bay JO, Tournilhac O, Tchirkov A.

Oncotarget. 2016 Aug 30;7(35):56976-56985. doi: 10.18632/oncotarget.10927.


Telomeres in aging and disease: lessons from zebrafish.

Carneiro MC, de Castro IP, Ferreira MG.

Dis Model Mech. 2016 Jul 1;9(7):737-48. doi: 10.1242/dmm.025130. Review.


Short telomere length and its correlation with gene mutations in myelodysplastic syndrome.

Hwang SM, Kim SY, Kim JA, Park HS, Park SN, Im K, Kim K, Kim SM, Lee DS.

J Hematol Oncol. 2016 Jul 28;9(1):62. doi: 10.1186/s13045-016-0287-9.


Therapeutic Targeting of Telomerase.

Jäger K, Walter M.

Genes (Basel). 2016 Jul 21;7(7). pii: E39. doi: 10.3390/genes7070039. Review.


Telomere uncapping at the crossroad between cell cycle arrest and carcinogenesis.

Gobbini E, Trovesi C, Cassani C, Longhese MP.

Mol Cell Oncol. 2014 Jul 28;1(1):e29901. doi: 10.4161/mco.29901. eCollection 2014. Review.


Demonstration of potential link between Helicobacter pylori related promoter CpG island methylation and telomere shortening in human gastric mucosa.

Tahara T, Shibata T, Okubo M, Kawamura T, Horiguchi N, Ishizuka T, Nakano N, Nagasaka M, Nakagawa Y, Ohmiya N.

Oncotarget. 2016 Jul 12;7(28):43989-43996. doi: 10.18632/oncotarget.9764.


Danazol Treatment for Telomere Diseases.

Townsley DM, Dumitriu B, Liu D, Biancotto A, Weinstein B, Chen C, Hardy N, Mihalek AD, Lingala S, Kim YJ, Yao J, Jones E, Gochuico BR, Heller T, Wu CO, Calado RT, Scheinberg P, Young NS.

N Engl J Med. 2016 May 19;374(20):1922-31. doi: 10.1056/NEJMoa1515319.


Guarding chromosomes from oxidative DNA damage to the very end.

Tan R, Lan L.

Acta Biochim Biophys Sin (Shanghai). 2016 Jul;48(7):617-22. doi: 10.1093/abbs/gmw040. Epub 2016 May 12. Review.


Stop pulling my strings - what telomeres taught us about the DNA damage response.

Lazzerini-Denchi E, Sfeir A.

Nat Rev Mol Cell Biol. 2016 Jun;17(6):364-78. doi: 10.1038/nrm.2016.43. Epub 2016 May 11. Review.


Myosins as fundamental components during tumorigenesis: diverse and indispensable.

Li YR, Yang WX.

Oncotarget. 2016 Jul 19;7(29):46785-46812. doi: 10.18632/oncotarget.8800. Review.

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