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Items: 1 to 20 of 117

1.

Site-specific azide-acetyllysine photochemistry on epigenetic readers for interactome profiling.

Sudhamalla B, Dey D, Breski M, Nguyen T, Islam K.

Chem Sci. 2017 Jun 1;8(6):4250-4256. doi: 10.1039/c7sc00284j. Epub 2017 Mar 14.

2.

Drug Discovery Targeting Bromodomain-Containing Protein 4.

Liu Z, Wang P, Chen H, Wold EA, Tian B, Brasier AR, Zhou J.

J Med Chem. 2017 Jun 8;60(11):4533-4558. doi: 10.1021/acs.jmedchem.6b01761. Epub 2017 Mar 2. Review.

3.

Bdf1 Bromodomains Are Essential for Meiosis and the Expression of Meiotic-Specific Genes.

García-Oliver E, Ramus C, Perot J, Arlotto M, Champleboux M, Mietton F, Battail C, Boland A, Deleuze JF, Ferro M, Couté Y, Govin J.

PLoS Genet. 2017 Jan 9;13(1):e1006541. doi: 10.1371/journal.pgen.1006541. eCollection 2017 Jan.

4.

Brd4 Activates Early Viral Transcription upon Human Papillomavirus 18 Infection of Primary Keratinocytes.

McKinney CC, Kim MJ, Chen D, McBride AA.

MBio. 2016 Nov 22;7(6). pii: e01644-16. doi: 10.1128/mBio.01644-16.

5.
6.

The BET bromodomain inhibitor exerts the most potent synergistic anticancer effects with quinone-containing compounds and anti-microtubule drugs.

Liu PY, Sokolowski N, Guo ST, Siddiqi F, Atmadibrata B, Telfer TJ, Sun Y, Zhang L, Yu D, Mccarroll J, Liu B, Yang RH, Guo XY, Tee AE, Itoh K, Wang J, Kavallaris M, Haber M, Norris MD, Cheung BB, Byrne JA, Ziegler DS, Marshall GM, Dinger ME, Codd R, Zhang XD, Liu T.

Oncotarget. 2016 Nov 29;7(48):79217-79232. doi: 10.18632/oncotarget.12640.

7.

Bromodomain and Extraterminal Protein Inhibition Blocks Growth of Triple-negative Breast Cancers through the Suppression of Aurora Kinases.

Sahni JM, Gayle SS, Bonk KL, Vite LC, Yori JL, Webb B, Ramos EK, Seachrist DD, Landis MD, Chang JC, Bradner JE, Keri RA.

J Biol Chem. 2016 Nov 4;291(45):23756-23768. Epub 2016 Sep 20.

PMID:
27650498
8.

Bromodomain 4: a cellular Swiss army knife.

Devaiah BN, Gegonne A, Singer DS.

J Leukoc Biol. 2016 Oct;100(4):679-686. Epub 2016 Jul 22. Review.

PMID:
27450555
9.

Chromatin Landscape of the IRF Genes and Role of the Epigenetic Reader BRD4.

Bachu M, Dey A, Ozato K.

J Interferon Cytokine Res. 2016 Jul;36(7):470-5. doi: 10.1089/jir.2015.0179.

10.

A hyperactive transcriptional state marks genome reactivation at the mitosis-G1 transition.

Hsiung CC, Bartman CR, Huang P, Ginart P, Stonestrom AJ, Keller CA, Face C, Jahn KS, Evans P, Sankaranarayanan L, Giardine B, Hardison RC, Raj A, Blobel GA.

Genes Dev. 2016 Jun 15;30(12):1423-39. doi: 10.1101/gad.280859.116.

11.

BRD4 is a histone acetyltransferase that evicts nucleosomes from chromatin.

Devaiah BN, Case-Borden C, Gegonne A, Hsu CH, Chen Q, Meerzaman D, Dey A, Ozato K, Singer DS.

Nat Struct Mol Biol. 2016 Jun;23(6):540-8. doi: 10.1038/nsmb.3228. Epub 2016 May 9.

12.

BET Bromodomain Proteins Brd2, Brd3 and Brd4 Selectively Regulate Metabolic Pathways in the Pancreatic β-Cell.

Deeney JT, Belkina AC, Shirihai OS, Corkey BE, Denis GV.

PLoS One. 2016 Mar 23;11(3):e0151329. doi: 10.1371/journal.pone.0151329. eCollection 2016.

13.

The Brd4 acetyllysine-binding protein is involved in activation of polyomavirus JC.

Wollebo HS, Bellizzi A, Cossari DH, Salkind J, Safak M, White MK.

J Neurovirol. 2016 Oct;22(5):615-625. Epub 2016 Mar 23.

PMID:
27007123
14.

The converging roles of BRD4 and gene transcription in pluripotency and oncogenesis.

Wu T, Donohoe ME.

RNA Dis. 2015 Jul;2(3). pii: e894. No abstract available.

15.

Failure to interact with Brd4 alters the ability of HPV16 E2 to regulate host genome expression and cellular movement.

Gauson EJ, Wang X, Dornan ES, Herzyk P, Bristol M, Morgan IM.

Virus Res. 2016 Jan 4;211:1-8. doi: 10.1016/j.virusres.2015.09.008. Epub 2015 Sep 10.

16.

The oncogenic BRD4-NUT chromatin regulator drives aberrant transcription within large topological domains.

Alekseyenko AA, Walsh EM, Wang X, Grayson AR, Hsi PT, Kharchenko PV, Kuroda MI, French CA.

Genes Dev. 2015 Jul 15;29(14):1507-23. doi: 10.1101/gad.267583.115.

17.

The BET family member BRD4 interacts with OCT4 and regulates pluripotency gene expression.

Wu T, Pinto HB, Kamikawa YF, Donohoe ME.

Stem Cell Reports. 2015 Mar 10;4(3):390-403. doi: 10.1016/j.stemcr.2015.01.012. Epub 2015 Feb 12.

18.

Mechanistic analysis of the role of bromodomain-containing protein 4 (BRD4) in BRD4-NUT oncoprotein-induced transcriptional activation.

Wang R, You J.

J Biol Chem. 2015 Jan 30;290(5):2744-58. doi: 10.1074/jbc.M114.600759. Epub 2014 Dec 15.

19.

BRD4 assists elongation of both coding and enhancer RNAs by interacting with acetylated histones.

Kanno T, Kanno Y, LeRoy G, Campos E, Sun HW, Brooks SR, Vahedi G, Heightman TD, Garcia BA, Reinberg D, Siebenlist U, O'Shea JJ, Ozato K.

Nat Struct Mol Biol. 2014 Dec;21(12):1047-57. doi: 10.1038/nsmb.2912. Epub 2014 Nov 10.

20.

Genome accessibility is widely preserved and locally modulated during mitosis.

Hsiung CC, Morrissey CS, Udugama M, Frank CL, Keller CA, Baek S, Giardine B, Crawford GE, Sung MH, Hardison RC, Blobel GA.

Genome Res. 2015 Feb;25(2):213-25. doi: 10.1101/gr.180646.114. Epub 2014 Nov 4.

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