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Items: 1 to 20 of 263


The role of Notch signaling in gastric carcinoma: molecular pathogenesis and novel therapeutic targets.

Yao Y, Ni Y, Zhang J, Wang H, Shao S.

Oncotarget. 2017 May 11;8(32):53839-53853. doi: 10.18632/oncotarget.17809. eCollection 2017 Aug 8. Review.


γ-Secretase inhibitors in cancer clinical trials are pharmacologically and functionally distinct.

Ran Y, Hossain F, Pannuti A, Lessard CB, Ladd GZ, Jung JI, Minter LM, Osborne BA, Miele L, Golde TE.

EMBO Mol Med. 2017 Jul;9(7):950-966. doi: 10.15252/emmm.201607265.


HER2 in Breast Cancer Stemness: A Negative Feedback Loop towards Trastuzumab Resistance.

Nami B, Wang Z.

Cancers (Basel). 2017 Apr 26;9(5). pii: E40. doi: 10.3390/cancers9050040. Review.


Regulation of Notch Signaling by the Heterogeneous Nuclear Ribonucleoprotein Hrp48 and Deltex in Drosophila melanogaster.

Dutta D, Paul MS, Singh A, Mutsuddi M, Mukherjee A.

Genetics. 2017 Jun;206(2):905-918. doi: 10.1534/genetics.116.198879. Epub 2017 Apr 10.


SheddomeDB: the ectodomain shedding database for membrane-bound shed markers.

Tien WS, Chen JH, Wu KP.

BMC Bioinformatics. 2017 Mar 14;18(Suppl 3):42. doi: 10.1186/s12859-017-1465-7. Review.


AIBP Limits Angiogenesis Through γ-Secretase-Mediated Upregulation of Notch Signaling.

Mao R, Meng S, Gu Q, Araujo-Gutierrez R, Kumar S, Yan Q, Almazan F, Youker KA, Fu Y, Pownall HJ, Cooke JP, Miller YI, Fang L.

Circ Res. 2017 May 26;120(11):1727-1739. doi: 10.1161/CIRCRESAHA.116.309754. Epub 2017 Mar 21.


Methods to investigate the structure and connectivity of the nervous system.

Lee D, Huang TH, De La Cruz A, Callejas A, Lois C.

Fly (Austin). 2017 Jul 3;11(3):224-238. doi: 10.1080/19336934.2017.1295189. Epub 2017 Feb 16.


Meprin Metalloproteases Generate Biologically Active Soluble Interleukin-6 Receptor to Induce Trans-Signaling.

Arnold P, Boll I, Rothaug M, Schumacher N, Schmidt F, Wichert R, Schneppenheim J, Lokau J, Pickhinke U, Koudelka T, Tholey A, Rabe B, Scheller J, Lucius R, Garbers C, Rose-John S, Becker-Pauly C.

Sci Rep. 2017 Mar 9;7:44053. doi: 10.1038/srep44053.


Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity.

Luca VC, Kim BC, Ge C, Kakuda S, Wu D, Roein-Peikar M, Haltiwanger RS, Zhu C, Ha T, Garcia KC.

Science. 2017 Mar 24;355(6331):1320-1324. doi: 10.1126/science.aaf9739. Epub 2017 Mar 2.


Turn It Down a Notch.

Carrieri FA, Dale JK.

Front Cell Dev Biol. 2017 Jan 18;4:151. doi: 10.3389/fcell.2016.00151. eCollection 2016. Review.


TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling.

Hurst LA, Dunmore BJ, Long L, Crosby A, Al-Lamki R, Deighton J, Southwood M, Yang X, Nikolic MZ, Herrera B, Inman GJ, Bradley JR, Rana AA, Upton PD, Morrell NW.

Nat Commun. 2017 Jan 13;8:14079. doi: 10.1038/ncomms14079.


The role of prostate tumor overexpressed 1 in cancer progression.

Cánovas V, Lleonart M, Morote J, Paciucci R.

Oncotarget. 2017 Feb 14;8(7):12451-12471. doi: 10.18632/oncotarget.14104. Review.


Inhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescence.

Revandkar A, Perciato ML, Toso A, Alajati A, Chen J, Gerber H, Dimitrov M, Rinaldi A, Delaleu N, Pasquini E, D'Antuono R, Pinton S, Losa M, Gnetti L, Arribas A, Fraering P, Bertoni F, Nepveu A, Alimonti A.

Nat Commun. 2016 Dec 12;7:13719. doi: 10.1038/ncomms13719.


NOTCH receptors in gastric and other gastrointestinal cancers: oncogenes or tumor suppressors?

Huang T, Zhou Y, Cheng AS, Yu J, To KF, Kang W.

Mol Cancer. 2016 Dec 9;15(1):80. Review.


Monitoring cell-cell contacts in vivo in transgenic animals.

Huang TH, Velho T, Lois C.

Development. 2016 Nov 1;143(21):4073-4084. Epub 2016 Sep 22.


Notch: A multi-functional integrating system of microenvironmental signals.

LaFoya B, Munroe JA, Mia MM, Detweiler MA, Crow JJ, Wood T, Roth S, Sharma B, Albig AR.

Dev Biol. 2016 Oct 15;418(2):227-41. doi: 10.1016/j.ydbio.2016.08.023. Epub 2016 Aug 24. Review.


Ehrlichia chaffeensis TRP120 Activates Canonical Notch Signaling To Downregulate TLR2/4 Expression and Promote Intracellular Survival.

Lina TT, Dunphy PS, Luo T, McBride JW.

MBio. 2016 Jul 5;7(4). pii: e00672-16. doi: 10.1128/mBio.00672-16.


Notch1 hallmarks fibrillary depositions in sporadic Alzheimer's disease.

Brai E, Alina Raio N, Alberi L.

Acta Neuropathol Commun. 2016 Jul 1;4(1):64. doi: 10.1186/s40478-016-0327-2. Erratum in: Acta Neuropathol Commun. 2016 Aug 25;4(1):90. DOI:10.1186/s40478-016-0360-1. Acta Neuropathol Commun. 2016 Aug 25;4(1):90.


ADAM10-Dependent Signaling Through Notch1 and Notch4 Controls Development of Organ-Specific Vascular Beds.

Alabi RO, Glomski K, Haxaire C, Weskamp G, Monette S, Blobel CP.

Circ Res. 2016 Aug 5;119(4):519-31. doi: 10.1161/CIRCRESAHA.115.307738. Epub 2016 Jun 27.


Does Notch play a tumor suppressor role across diverse squamous cell carcinomas?

Zhang M, Biswas S, Qin X, Gong W, Deng W, Yu H.

Cancer Med. 2016 Aug;5(8):2048-60. doi: 10.1002/cam4.731. Epub 2016 May 26. Review.

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