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Items: 1 to 20 of 130


A One-Step PCR-Based Assay to Evaluate the Efficiency and Precision of Genomic DNA-Editing Tools.

Germini D, Bou Saada Y, Tsfasman T, Osina K, Robin C, Lomov N, Rubtsov M, Sjakste N, Lipinski M, Vassetzky Y.

Mol Ther Methods Clin Dev. 2017 Mar 8;5:43-50. doi: 10.1016/j.omtm.2017.03.001. eCollection 2017 Jun 16.


CRISPR-Cas9-guided oncogenic chromosomal translocations with conditional fusion protein expression in human mesenchymal cells.

Vanoli F, Tomishima M, Feng W, Lamribet K, Babin L, Brunet E, Jasin M.

Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):3696-3701. doi: 10.1073/pnas.1700622114. Epub 2017 Mar 21.


CRISPR/Cas9 Gene Drive: Growing Pains for a New Technology.

Reed FA.

Genetics. 2017 Mar;205(3):1037-1039. doi: 10.1534/genetics.116.198887. No abstract available.


Generation of Gross Chromosomal Rearrangements by a Single Engineered DNA Double Strand Break.

Qiu Z, Zhang Z, Roschke A, Varga T, Aplan PD.

Sci Rep. 2017 Feb 22;7:43156. doi: 10.1038/srep43156.


Immature Lymphocytes Inhibit Rag1 and Rag2 Transcription and V(D)J Recombination in Response to DNA Double-Strand Breaks.

Fisher MR, Rivera-Reyes A, Bloch NB, Schatz DG, Bassing CH.

J Immunol. 2017 Apr 1;198(7):2943-2956. doi: 10.4049/jimmunol.1601639. Epub 2017 Feb 17.


Generation of conditional oncogenic chromosomal translocations using CRISPR-Cas9 genomic editing and homology-directed repair.

Spraggon L, Martelotto LG, Hmeljak J, Hitchman TD, Wang J, Wang L, Slotkin EK, Fan PD, Reis-Filho JS, Ladanyi M.

J Pathol. 2017 May;242(1):102-112. doi: 10.1002/path.4883. Epub 2017 Mar 30.


Role of DNA repair machinery and p53 in the testicular germ cell cancer: a review.

Romano FJ, Rossetti S, Conteduca V, Schepisi G, Cavaliere C, Di Franco R, La Mantia E, Castaldo L, Nocerino F, Ametrano G, Cappuccio F, Malzone G, Montanari M, Vanacore D, Quagliariello V, Piscitelli R, Pepe MF, Berretta M, D'Aniello C, PerdonĂ  S, Muto P, Botti G, Ciliberto G, Veneziani BM, De Falco F, Maiolino P, Caraglia M, Montella M, De Giorgi U, Facchini G.

Oncotarget. 2016 Dec 20;7(51):85641-85649. doi: 10.18632/oncotarget.13063. Review.


A 90-Day Feeding Study in Rats to Assess the Safety of Genetically Engineered Pork.

Xiao GJ, Jiang SW, Qian LL, Cai CB, Wang QQ, Ma DZ, Li B, Xie SS, Cui WT, Li K.

PLoS One. 2016 Nov 3;11(11):e0165843. doi: 10.1371/journal.pone.0165843. eCollection 2016.


Mechanistic Modelling and Bayesian Inference Elucidates the Variable Dynamics of Double-Strand Break Repair.

Woods ML, Barnes CP.

PLoS Comput Biol. 2016 Oct 14;12(10):e1005131. doi: 10.1371/journal.pcbi.1005131. eCollection 2016 Oct.


Therapy-related myeloid neoplasms - what have we learned so far?

Zahid MF, Parnes A, Savani BN, Litzow MR, Hashmi SK.

World J Stem Cells. 2016 Aug 26;8(8):231-42. doi: 10.4252/wjsc.v8.i8.231. Review.


Do DNA Double-Strand Breaks Drive Aging?

White RR, Vijg J.

Mol Cell. 2016 Sep 1;63(5):729-38. doi: 10.1016/j.molcel.2016.08.004. Review.


Somatic Engineering of Oncogenic Chromosomal Rearrangements: A Perspective.

Maddalo D, Ventura A.

Cancer Res. 2016 Sep 1;76(17):4918-23. doi: 10.1158/0008-5472.CAN-16-0726. Epub 2016 Aug 12. Review.


Novel Biological Approaches for Testing the Contributions of Single DSBs and DSB Clusters to the Biological Effects of High LET Radiation.

Mladenova V, Mladenov E, Iliakis G.

Front Oncol. 2016 Jun 28;6:163. doi: 10.3389/fonc.2016.00163. eCollection 2016. Review.


Defining chromosomal translocation risks in cancer.

Hogenbirk MA, Heideman MR, de Rink I, Velds A, Kerkhoven RM, Wessels LF, Jacobs H.

Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):E3649-56. doi: 10.1073/pnas.1602025113. Epub 2016 Jun 14.


The histone deacetylase inhibitor PCI-24781 as a putative radiosensitizer in pediatric glioblastoma cell lines.

de Andrade PV, Andrade AF, de Paula Queiroz RG, Scrideli CA, Tone LG, Valera ET.

Cancer Cell Int. 2016 Apr 18;16:31. doi: 10.1186/s12935-016-0306-5. eCollection 2016.


The DNA resection protein CtIP promotes mammary tumorigenesis.

Reczek CR, Shakya R, Miteva Y, Szabolcs M, Ludwig T, Baer R.

Oncotarget. 2016 May 31;7(22):32172-83. doi: 10.18632/oncotarget.8605.


Dietary lycopene intake and risk of prostate cancer defined by ERG protein expression.

Graff RE, Pettersson A, Lis RT, Ahearn TU, Markt SC, Wilson KM, Rider JR, Fiorentino M, Finn S, Kenfield SA, Loda M, Giovannucci EL, Rosner B, Mucci LA.

Am J Clin Nutr. 2016 Mar;103(3):851-60. doi: 10.3945/ajcn.115.118703. Epub 2016 Jan 27.


Towards a new era in medicine: therapeutic genome editing.

Porteus MH.

Genome Biol. 2015 Dec 22;16:286. doi: 10.1186/s13059-015-0859-y. Review.


The role of Drosophila mismatch repair in suppressing recombination between diverged sequences.

Do AT, LaRocque JR.

Sci Rep. 2015 Nov 30;5:17601. doi: 10.1038/srep17601.


Cross talk of tyrosine kinases with the DNA damage signaling pathways.

Mahajan K, Mahajan NP.

Nucleic Acids Res. 2015 Dec 15;43(22):10588-601. doi: 10.1093/nar/gkv1166. Epub 2015 Nov 5. Review.

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