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Items: 1 to 20 of 154

1.

Chk1 Inhibition of the Replication Factor Drf1 Guarantees Cell-Cycle Elongation at the Xenopus laevis Mid-blastula Transition.

Collart C, Smith JC, Zegerman P.

Dev Cell. 2017 Jul 10;42(1):82-96.e3. doi: 10.1016/j.devcel.2017.06.010.

2.

Activation of CHK1 in Supporting Cells Indirectly Promotes Hair Cell Survival.

Jadali A, Ying YM, Kwan KY.

Front Cell Neurosci. 2017 May 18;11:137. doi: 10.3389/fncel.2017.00137. eCollection 2017.

3.

Targeting the ATR-CHK1 Axis in Cancer Therapy.

Rundle S, Bradbury A, Drew Y, Curtin NJ.

Cancers (Basel). 2017 Apr 27;9(5). pii: E41. doi: 10.3390/cancers9050041. Review.

4.

Initiation of Drosophila chorion gene amplification requires Claspin and mus101, whereas Claspin, but not mus101, plays a major role during elongation.

Choi SH, Park JH, Nguyen TTN, Shim HJ, Song YH.

Dev Dyn. 2017 Jun;246(6):466-474. doi: 10.1002/dvdy.24499. Epub 2017 Apr 11.

5.

LC-MS/MS assay for the simultaneous quantitation of the ATM inhibitor AZ31 and the ATR inhibitor AZD6738 in mouse plasma.

Kiesel BF, Shogan JC, Rachid M, Parise RA, Vendetti FP, Bakkenist CJ, Beumer JH.

J Pharm Biomed Anal. 2017 May 10;138:158-165. doi: 10.1016/j.jpba.2017.01.055. Epub 2017 Feb 4.

PMID:
28213176
6.

Ataxin-3 promotes genome integrity by stabilizing Chk1.

Tu Y, Liu H, Zhu X, Shen H, Ma X, Wang F, Huang M, Gong J, Li X, Wang Y, Guo C, Tang TS.

Nucleic Acids Res. 2017 May 5;45(8):4532-4549. doi: 10.1093/nar/gkx095.

7.

Pharmacologic ATM but not ATR kinase inhibition abrogates p21-dependent G1 arrest and promotes gastrointestinal syndrome after total body irradiation.

Vendetti FP, Leibowitz BJ, Barnes J, Schamus S, Kiesel BF, Abberbock S, Conrads T, Clump DA, Cadogan E, O'Connor MJ, Yu J, Beumer JH, Bakkenist CJ.

Sci Rep. 2017 Feb 1;7:41892. doi: 10.1038/srep41892.

8.

Checkpoint kinase inhibitor AZD7762 strongly sensitises urothelial carcinoma cells to gemcitabine.

Isono M, Hoffmann MJ, Pinkerneil M, Sato A, Michaelis M, Cinatl J Jr, Niegisch G, Schulz WA.

J Exp Clin Cancer Res. 2017 Jan 3;36(1):1. doi: 10.1186/s13046-016-0473-1.

9.

A Role for the Twins Protein Phosphatase (PP2A-B55) in the Maintenance of Drosophila Genome Integrity.

Merigliano C, Marzio A, Renda F, Somma MP, Gatti M, Vernì F.

Genetics. 2017 Mar;205(3):1151-1167. doi: 10.1534/genetics.116.192781. Epub 2016 Dec 30.

PMID:
28040742
10.

Prospects for the Use of ATR Inhibitors to Treat Cancer.

Wagner JM, Kaufmann SH.

Pharmaceuticals (Basel). 2010 Apr 28;3(5):1311-1334. Review.

11.

Trial Watch: Targeting ATM-CHK2 and ATR-CHK1 pathways for anticancer therapy.

Manic G, Obrist F, Sistigu A, Vitale I.

Mol Cell Oncol. 2015 Feb 23;2(4):e1012976. doi: 10.1080/23723556.2015.1012976. eCollection 2015 Oct-Dec. Review.

12.

A dual molecular analogue tuner for dissecting protein function in mammalian cells.

Brosh R, Hrynyk I, Shen J, Waghray A, Zheng N, Lemischka IR.

Nat Commun. 2016 May 27;7:11742. doi: 10.1038/ncomms11742.

13.

Targeting radioresistant breast cancer cells by single agent CHK1 inhibitor via enhancing replication stress.

Zhang Y, Lai J, Du Z, Gao J, Yang S, Gorityala S, Xiong X, Deng O, Ma Z, Yan C, Susana G, Xu Y, Zhang J.

Oncotarget. 2016 Jun 7;7(23):34688-702. doi: 10.18632/oncotarget.9156.

14.

Checkpoint Kinase 1 Activation Enhances Intestinal Epithelial Barrier Function via Regulation of Claudin-5 Expression.

Watari A, Hasegawa M, Yagi K, Kondoh M.

PLoS One. 2016 Jan 4;11(1):e0145631. doi: 10.1371/journal.pone.0145631. eCollection 2016.

15.

A subset of cancer cell lines is acutely sensitive to the Chk1 inhibitor MK-8776 as monotherapy due to CDK2 activation in S phase.

Sakurikar N, Thompson R, Montano R, Eastman A.

Oncotarget. 2016 Jan 12;7(2):1380-94. doi: 10.18632/oncotarget.6364.

16.

The orally active and bioavailable ATR kinase inhibitor AZD6738 potentiates the anti-tumor effects of cisplatin to resolve ATM-deficient non-small cell lung cancer in vivo.

Vendetti FP, Lau A, Schamus S, Conrads TP, O'Connor MJ, Bakkenist CJ.

Oncotarget. 2015 Dec 29;6(42):44289-305. doi: 10.18632/oncotarget.6247.

17.

Cell proliferation potency is independent of FGF4 signaling in trophoblast stem cells derived from androgenetic embryos.

Ogawa H, Takyu R, Morimoto H, Toei S, Sakon H, Goto S, Moriya S, Kono T.

J Reprod Dev. 2016;62(1):51-8. doi: 10.1262/jrd.2015-097. Epub 2015 Oct 26.

18.

Targeting the Checkpoint to Kill Cancer Cells.

Benada J, Macurek L.

Biomolecules. 2015 Aug 18;5(3):1912-37. doi: 10.3390/biom5031912. Review.

19.

Combined inhibition of the cell cycle related proteins Wee1 and Chk1/2 induces synergistic anti-cancer effect in melanoma.

Magnussen GI, Emilsen E, Giller Fleten K, Engesæter B, Nähse-Kumpf V, Fjær R, Slipicevic A, Flørenes VA.

BMC Cancer. 2015 Jun 10;15:462. doi: 10.1186/s12885-015-1474-8.

20.

DNA damage response and spindle assembly checkpoint function throughout the cell cycle to ensure genomic integrity.

Lawrence KS, Chau T, Engebrecht J.

PLoS Genet. 2015 Apr 21;11(4):e1005150. doi: 10.1371/journal.pgen.1005150. eCollection 2015 Apr.

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