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Items: 1 to 20 of 41

1.

Multiscale mutation clustering algorithm identifies pan-cancer mutational clusters associated with pathway-level changes in gene expression.

Poole W, Leinonen K, Shmulevich I, Knijnenburg TA, Bernard B.

PLoS Comput Biol. 2017 Feb 7;13(2):e1005347. doi: 10.1371/journal.pcbi.1005347. eCollection 2017 Feb. Erratum in: PLoS Comput Biol. 2017 Apr 6;13(4):e1005472.

2.

The SCFβ-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis.

Shimizu K, Fukushima H, Ogura K, Lien EC, Nihira NT, Zhang J, North BJ, Guo A, Nagashima K, Nakagawa T, Hoshikawa S, Watahiki A, Okabe K, Yamada A, Toker A, Asara JM, Fukumoto S, Nakayama KI, Nakayama K, Inuzuka H, Wei W.

Sci Signal. 2017 Jan 3;10(460). pii: eaah4117. doi: 10.1126/scisignal.aah4117.

PMID:
28049764
3.

Point mutations in the tumor suppressor Smad4/DPC4 enhance its phosphorylation by GSK3 and reversibly inactivate TGF-β signaling.

Demagny H, De Robertis EM.

Mol Cell Oncol. 2015 Apr 14;3(1):e1025181. doi: 10.1080/23723556.2015.1025181. eCollection 2016 Jan.

4.

The ubiquitin-proteasome system and activation of NF-κB: involvement of the ubiquitin ligase KPC1 in p105 processing and tumor suppression.

Kravtsova-Ivantsiv Y, Ciechanover A.

Mol Cell Oncol. 2015 May 26;2(4):e1054552. doi: 10.1080/23723556.2015.1054552. eCollection 2015 Oct-Dec.

5.

The Ubiquitination of NF-κB Subunits in the Control of Transcription.

Collins PE, Mitxitorena I, Carmody RJ.

Cells. 2016 May 12;5(2). pii: E23. doi: 10.3390/cells5020023. Review.

6.

Lys29-linkage of ASK1 by Skp1-Cullin 1-Fbxo21 ubiquitin ligase complex is required for antiviral innate response.

Yu Z, Chen T, Li X, Yang M, Tang S, Zhu X, Gu Y, Su X, Xia M, Li W, Zhang X, Wang Q, Cao X, Wang J.

Elife. 2016 Apr 11;5. pii: e14087. doi: 10.7554/eLife.14087.

7.

The Regulation of NF-κB Subunits by Phosphorylation.

Christian F, Smith EL, Carmody RJ.

Cells. 2016 Mar 18;5(1). pii: E12. doi: 10.3390/cells5010012. Review.

8.

The ORF61 Protein Encoded by Simian Varicella Virus and Varicella-Zoster Virus Inhibits NF-κB Signaling by Interfering with IκBα Degradation.

Whitmer T, Malouli D, Uebelhoer LS, DeFilippis VR, Früh K, Verweij MC.

J Virol. 2015 Sep;89(17):8687-700. doi: 10.1128/JVI.01149-15. Epub 2015 Jun 17.

9.

The role of aberrant proteolysis in lymphomagenesis.

Sahasrabuddhe AA, Elenitoba-Johnson KS.

Curr Opin Hematol. 2015 Jul;22(4):369-78. doi: 10.1097/MOH.0000000000000156. Review.

10.

Downregulation of urea transporter UT-A1 activity by 14-3-3 protein.

Feng X, Li Z, Du Y, Fu H, Klein JD, Cai H, Sands JM, Chen G.

Am J Physiol Renal Physiol. 2015 Jul 1;309(1):F71-8. doi: 10.1152/ajprenal.00546.2014. Epub 2015 May 20.

11.

Ras regulates SCF(β-TrCP) protein activity and specificity via its effector protein NORE1A.

Schmidt ML, Donninger H, Clark GJ.

J Biol Chem. 2014 Nov 7;289(45):31102-10. doi: 10.1074/jbc.M114.594283. Epub 2014 Sep 12.

12.

Beyond ubiquitination: the atypical functions of Fbxo7 and other F-box proteins.

Nelson DE, Randle SJ, Laman H.

Open Biol. 2013 Oct 9;3(10):130131. doi: 10.1098/rsob.130131. Review.

13.

The serine phosphatase SerB of Porphyromonas gingivalis suppresses IL-8 production by dephosphorylation of NF-κB RelA/p65.

Takeuchi H, Hirano T, Whitmore SE, Morisaki I, Amano A, Lamont RJ.

PLoS Pathog. 2013;9(4):e1003326. doi: 10.1371/journal.ppat.1003326. Epub 2013 Apr 18.

14.

Coordinate regulation of TPL-2 and NF-κB signaling in macrophages by NF-κB1 p105.

Yang HT, Papoutsopoulou S, Belich M, Brender C, Janzen J, Gantke T, Handley M, Ley SC.

Mol Cell Biol. 2012 Sep;32(17):3438-51. doi: 10.1128/MCB.00564-12. Epub 2012 Jun 25.

15.

Fbxw7α- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma.

Busino L, Millman SE, Scotto L, Kyratsous CA, Basrur V, O'Connor O, Hoffmann A, Elenitoba-Johnson KS, Pagano M.

Nat Cell Biol. 2012 Mar 4;14(4):375-85. doi: 10.1038/ncb2463.

16.

Mitochondrial ubiquitin ligase MITOL blocks S-nitrosylated MAP1B-light chain 1-mediated mitochondrial dysfunction and neuronal cell death.

Yonashiro R, Kimijima Y, Shimura T, Kawaguchi K, Fukuda T, Inatome R, Yanagi S.

Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2382-7. doi: 10.1073/pnas.1114985109. Epub 2012 Jan 30.

17.

NF-κB, the first quarter-century: remarkable progress and outstanding questions.

Hayden MS, Ghosh S.

Genes Dev. 2012 Feb 1;26(3):203-34. doi: 10.1101/gad.183434.111. Review.

18.

Disruption of IkappaB kinase (IKK)-mediated RelA serine 536 phosphorylation sensitizes human multiple myeloma cells to histone deacetylase (HDAC) inhibitors.

Dai Y, Chen S, Wang L, Pei XY, Funk VL, Kramer LB, Dent P, Grant S.

J Biol Chem. 2011 Sep 30;286(39):34036-50. doi: 10.1074/jbc.M111.284216. Epub 2011 Aug 4.

19.

Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinase.

Gantke T, Sriskantharajah S, Ley SC.

Cell Res. 2011 Jan;21(1):131-45. doi: 10.1038/cr.2010.173. Epub 2010 Dec 7. Review. Erratum in: Cell Res. 2011 Apr;21(4):704.

20.

Cot/tpl2 (MAP3K8) mediates myeloperoxidase activity and hypernociception following peripheral inflammation.

Soria-Castro I, Krzyzanowska A, Pelaéz ML, Regadera J, Ferrer G, Montoliu L, Rodríguez-Ramos R, Fernández M, Alemany S.

J Biol Chem. 2010 Oct 29;285(44):33805-15. doi: 10.1074/jbc.M110.169409. Epub 2010 Aug 24.

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