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Items: 1 to 20 of 120


Determinants of Isoform-Specific Gating Kinetics of hERG1 Channel: Combined Experimental and Simulation Study.

Perissinotti LL, De Biase PM, Guo J, Yang PC, Lee MC, Clancy CE, Duff HJ, Noskov SY.

Front Physiol. 2018 Apr 12;9:207. doi: 10.3389/fphys.2018.00207. eCollection 2018.


Simultaneous Quantification of Spatially Discordant Alternans in Voltage and Intracellular Calcium in Langendorff-Perfused Rabbit Hearts and Inconsistencies with Models of Cardiac Action Potentials and Ca Transients.

Uzelac I, Ji YC, Hornung D, Schröder-Scheteling J, Luther S, Gray RA, Cherry EM, Fenton FH.

Front Physiol. 2017 Oct 20;8:819. doi: 10.3389/fphys.2017.00819. eCollection 2017.


Differential calcium sensitivity in NaV 1.5 mixed syndrome mutants.

Abdelsayed M, Baruteau AE, Gibbs K, Sanatani S, Krahn AD, Probst V, Ruben PC.

J Physiol. 2017 Sep 15;595(18):6165-6186. doi: 10.1113/JP274536. Epub 2017 Aug 20.


A multiscale computational modelling approach predicts mechanisms of female sex risk in the setting of arousal-induced arrhythmias.

Yang PC, Perissinotti LL, López-Redondo F, Wang Y, DeMarco KR, Jeng MT, Vorobyov I, Harvey RD, Kurokawa J, Noskov SY, Clancy CE.

J Physiol. 2017 Jul 15;595(14):4695-4723. doi: 10.1113/JP273142. Epub 2017 Jun 14.


Impairment of Excitation-Contraction Coupling in Right Ventricular Hypertrophied Muscle with Fibrosis Induced by Pulmonary Artery Banding.

Kusakari Y, Urashima T, Shimura D, Amemiya E, Miyasaka G, Yokota S, Fujimoto Y, Akaike T, Inoue T, Minamisawa S.

PLoS One. 2017 Jan 9;12(1):e0169564. doi: 10.1371/journal.pone.0169564. eCollection 2017.


Molecular Pathophysiology of Congenital Long QT Syndrome.

Bohnen MS, Peng G, Robey SH, Terrenoire C, Iyer V, Sampson KJ, Kass RS.

Physiol Rev. 2017 Jan;97(1):89-134. Review.


Reply from Pei-Chi Yang, Jonathan D. Moreno, Mao-Tsuen Jeng, Xander H. T. Wehrens, Sergei Noskov and Colleen E. Clancy.

Yang PC, Moreno JD, Jeng MT, Wehrens XH, Noskov S, Clancy CE.

J Physiol. 2016 Nov 1;594(21):6433-6435. doi: 10.1113/JP273143. No abstract available.


Sex hormonal regulation of cardiac ion channels in drug-induced QT syndromes.

Kurokawa J, Kodama M, Clancy CE, Furukawa T.

Pharmacol Ther. 2016 Dec;168:23-28. doi: 10.1016/j.pharmthera.2016.09.004. Epub 2016 Sep 4. Review.


Precisely parameterized experimental and computational models of tissue organization.

Molitoris JM, Paliwal S, Sekar RB, Blake R, Park J, Trayanova NA, Tung L, Levchenko A.

Integr Biol (Camb). 2016 Feb;8(2):230-242. doi: 10.1039/c5ib00270b. Epub 2016 Jan 29.


Computational Approaches to Understanding the Role of Fibroblast-Myocyte Interactions in Cardiac Arrhythmogenesis.

Brown TR, Krogh-Madsen T, Christini DJ.

Biomed Res Int. 2015;2015:465714. doi: 10.1155/2015/465714. Epub 2015 Oct 25. Review.


Conditions for Waveblock Due to Anisotropy in a Model of Human Ventricular Tissue.

Kudryashova NN, Kazbanov IV, Panfilov AV, Agladze KI.

PLoS One. 2015 Nov 2;10(11):e0141832. doi: 10.1371/journal.pone.0141832. eCollection 2015.


Slow [Na]i Changes and Positive Feedback Between Membrane Potential and [Ca]i Underlie Intermittent Early Afterdepolarizations and Arrhythmias.

Xie Y, Liao Z, Grandi E, Shiferaw Y, Bers DM.

Circ Arrhythm Electrophysiol. 2015 Dec;8(6):1472-80. doi: 10.1161/CIRCEP.115.003085. Epub 2015 Sep 25.


Implementation of Contraction to Electrophysiological Ventricular Myocyte Models, and Their Quantitative Characterization via Post-Extrasystolic Potentiation.

Ji YC, Gray RA, Fenton FH.

PLoS One. 2015 Aug 28;10(8):e0135699. doi: 10.1371/journal.pone.0135699. eCollection 2015.


Regulation of cardiac cellular bioenergetics: mechanisms and consequences.

Tran K, Loiselle DS, Crampin EJ.

Physiol Rep. 2015 Jul;3(7). pii: e12464. doi: 10.14814/phy2.12464.


Cell-specific cardiac electrophysiology models.

Groenendaal W, Ortega FA, Kherlopian AR, Zygmunt AC, Krogh-Madsen T, Christini DJ.

PLoS Comput Biol. 2015 Apr 30;11(4):e1004242. doi: 10.1371/journal.pcbi.1004242. eCollection 2015 Apr.


Deranged sodium to sudden death.

Clancy CE, Chen-Izu Y, Bers DM, Belardinelli L, Boyden PA, Csernoch L, Despa S, Fermini B, Hool LC, Izu L, Kass RS, Lederer WJ, Louch WE, Maack C, Matiazzi A, Qu Z, Rajamani S, Rippinger CM, Sejersted OM, O'Rourke B, Weiss JN, Varró A, Zaza A.

J Physiol. 2015 Mar 15;593(6):1331-45. doi: 10.1113/jphysiol.2014.281204. Review. Erratum in: J Physiol. 2016 Mar 15;594(6):1791.


Ca(2+) cycling properties are conserved despite bradycardic effects of heart failure in sinoatrial node cells.

Verkerk AO, van Borren MM, van Ginneken AC, Wilders R.

Front Physiol. 2015 Feb 2;6:18. doi: 10.3389/fphys.2015.00018. eCollection 2015.


Cellular cardiac electrophysiology modeling with Chaste and CellML.

Cooper J, Spiteri RJ, Mirams GR.

Front Physiol. 2015 Jan 6;5:511. doi: 10.3389/fphys.2014.00511. eCollection 2014.


A computational modelling approach combined with cellular electrophysiology data provides insights into the therapeutic benefit of targeting the late Na+ current.

Yang PC, Song Y, Giles WR, Horvath B, Chen-Izu Y, Belardinelli L, Rajamani S, Clancy CE.

J Physiol. 2015 Mar 15;593(6):1429-42. doi: 10.1113/jphysiol.2014.279554.

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