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Blockade of the LRP16-PKR-NF-κB signaling axis sensitizes colorectal carcinoma cells to DNA-damaging cytotoxic therapy.

Li X, Wu Z, An X, Mei Q, Bai M, Hanski L, Li X, Ahola T, Han W.

Elife. 2017 Aug 18;6. pii: e27301. doi: 10.7554/eLife.27301.


A Map of the Arenavirus Nucleoprotein-Host Protein Interactome Reveals that Junín Virus Selectively Impairs the Antiviral Activity of Double-Stranded RNA-Activated Protein Kinase (PKR).

King BR, Hershkowitz D, Eisenhauer PL, Weir ME, Ziegler CM, Russo J, Bruce EA, Ballif BA, Botten J.

J Virol. 2017 Jul 12;91(15). pii: e00763-17. doi: 10.1128/JVI.00763-17. Print 2017 Aug 1.


Discrimination of Self and Non-Self Ribonucleic Acids.

Gebhardt A, Laudenbach BT, Pichlmair A.

J Interferon Cytokine Res. 2017 May;37(5):184-197. doi: 10.1089/jir.2016.0092. Review.


Interferon Gamma Prevents Infectious Entry of Human Papillomavirus 16 via an L2-Dependent Mechanism.

Day PM, Thompson CD, Lowy DR, Schiller JT.

J Virol. 2017 Apr 28;91(10). pii: e00168-17. doi: 10.1128/JVI.00168-17. Print 2017 May 15.


Molecular cloning, polymorphism, and functional activity of the bovine and water buffalo Mx2 gene promoter region.

Babiker HA, Saito T, Nakatsu Y, Takasuga S, Morita M, Sugimoto Y, Ueda J, Watanabe T.

Springerplus. 2016 Dec 22;5(1):2109. doi: 10.1186/s40064-016-3729-5. eCollection 2016.


Interferon β (IFN-β) Production during the Double-stranded RNA (dsRNA) Response in Hepatocytes Involves Coordinated and Feedforward Signaling through Toll-like Receptor 3 (TLR3), RNA-dependent Protein Kinase (PKR), Inducible Nitric Oxide Synthase (iNOS), and Src Protein.

Zhang L, Xiang W, Wang G, Yan Z, Zhu Z, Guo Z, Sengupta R, Chen AF, Loughran PA, Lu B, Wang Q, Billiar TR.

J Biol Chem. 2016 Jul 15;291(29):15093-107. doi: 10.1074/jbc.M116.717942. Epub 2016 May 17.


p58(IPK) suppresses NLRP3 inflammasome activation and IL-1β production via inhibition of PKR in macrophages.

Boriushkin E, Wang JJ, Li J, Bhatta M, Zhang SX.

Sci Rep. 2016 Apr 26;6:25013. doi: 10.1038/srep25013.


Alphaherpesvirus Subversion of Stress-Induced Translational Arrest.

Finnen RL, Banfield BW.

Viruses. 2016 Mar 15;8(3):81. doi: 10.3390/v8030081. Review.


PKR Transduces MDA5-Dependent Signals for Type I IFN Induction.

Pham AM, Santa Maria FG, Lahiri T, Friedman E, Marié IJ, Levy DE.

PLoS Pathog. 2016 Mar 3;12(3):e1005489. doi: 10.1371/journal.ppat.1005489. eCollection 2016 Mar.


ONC201 kills solid tumor cells by triggering an integrated stress response dependent on ATF4 activation by specific eIF2α kinases.

Kline CL, Van den Heuvel AP, Allen JE, Prabhu VV, Dicker DT, El-Deiry WS.

Sci Signal. 2016 Feb 16;9(415):ra18. doi: 10.1126/scisignal.aac4374.


Quantitative Proteomic Analysis of BHK-21 Cells Infected with Foot-and-Mouth Disease Virus Serotype Asia 1.

Guo HC, Jin Y, Han SC, Sun SQ, Wei YQ, Liu XJ, Feng X, Liu DX, Liu XT.

PLoS One. 2015 Jul 10;10(7):e0132384. doi: 10.1371/journal.pone.0132384. eCollection 2015.


TNF-α Induced by Hepatitis C Virus via TLR7 and TLR8 in Hepatocytes Supports Interferon Signaling via an Autocrine Mechanism.

Lee J, Tian Y, Chan ST, Kim JY, Cho C, Ou JH.

PLoS Pathog. 2015 May 29;11(5):e1004937. doi: 10.1371/journal.ppat.1004937. eCollection 2015 May.


Role of p58IPK in Endoplasmic Reticulum Stress-associated Apoptosis and Inflammation.

Boriushkin E, Wang JJ, Zhang SX.

J Ophthalmic Vis Res. 2014 Jan;9(1):134-43. No abstract available.


PKR is activated by cellular dsRNAs during mitosis and acts as a mitotic regulator.

Kim Y, Lee JH, Park JE, Cho J, Yi H, Kim VN.

Genes Dev. 2014 Jun 15;28(12):1310-22. doi: 10.1101/gad.242644.114.


TRAIL-R1 is a negative regulator of pro-inflammatory responses and modulates long-term sequelae resulting from Chlamydia trachomatis infections in humans.

Al-Kuhlani M, Rothschild J, Pal S, de la Maza LM, Ouburg S, Morré SA, Dean D, Ojcius DM.

PLoS One. 2014 Apr 2;9(4):e93939. doi: 10.1371/journal.pone.0093939. eCollection 2014. Erratum in: PLoS One. 2014;9(8):e106964. Rothchild, James [corrected to Rothschild, James].


Activation of the PKR/eIF2α signaling cascade inhibits replication of Newcastle disease virus.

Zhang S, Sun Y, Chen H, Dai Y, Zhan Y, Yu S, Qiu X, Tan L, Song C, Ding C.

Virol J. 2014 Mar 31;11:62. doi: 10.1186/1743-422X-11-62.

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