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Rac3 Regulates Cell Invasion, Migration and EMT in Lung Adenocarcinoma through p38 MAPK Pathway.

Zhang C, Liu T, Wang G, Wang H, Che X, Gao X, Liu H.

J Cancer. 2017 Aug 2;8(13):2511-2522. doi: 10.7150/jca.18161. eCollection 2017.


An integrated method for the identification of novel genes related to oral cancer.

Chen L, Yang J, Xing Z, Yuan F, Shu Y, Zhang Y, Kong X, Huang T, Li H, Cai YD.

PLoS One. 2017 Apr 6;12(4):e0175185. doi: 10.1371/journal.pone.0175185. eCollection 2017.


Phosphorylated cortactin recruits Vav2 guanine nucleotide exchange factor to activate Rac3 and promote invadopodial function in invasive breast cancer cells.

Rosenberg BJ, Gil-Henn H, Mader CC, Halo T, Yin T, Condeelis J, Machida K, Wu YI, Koleske AJ.

Mol Biol Cell. 2017 May 15;28(10):1347-1360. doi: 10.1091/mbc.E16-12-0885. Epub 2017 Mar 29.


Dual Site Phosphorylation of Caspase-7 by PAK2 Blocks Apoptotic Activity by Two Distinct Mechanisms.

Eron SJ, Raghupathi K, Hardy JA.

Structure. 2017 Jan 3;25(1):27-39. doi: 10.1016/j.str.2016.11.001. Epub 2016 Nov 23.


Deregulation of Rho GTPases in cancer.

Porter AP, Papaioannou A, Malliri A.

Small GTPases. 2016 Jul 2;7(3):123-38. doi: 10.1080/21541248.2016.1173767. Epub 2016 Apr 22. Review.


Evading anti-angiogenic therapy: resistance to anti-angiogenic therapy in solid tumors.

Dey N, De P, Brian LJ.

Am J Transl Res. 2015 Oct 15;7(10):1675-98. eCollection 2015. Review.


p21-Activated Kinases 1, 2 and 4 in Endometrial Cancers: Effects on Clinical Outcomes and Cell Proliferation.

Siu MK, Kong DS, Ngai SY, Chan HY, Jiang L, Wong ES, Liu SS, Chan KK, Ngan HY, Cheung AN.

PLoS One. 2015 Jul 28;10(7):e0133467. doi: 10.1371/journal.pone.0133467. eCollection 2015.


Pharmacokinetics of Rac inhibitor EHop-016 in mice by ultra-performance liquid chromatography tandem mass spectrometry.

Humphries-Bickley T, Castillo-Pichardo L, Corujo-Carro F, Duconge J, Hernandez-O'Farrill E, Vlaar C, Rodriguez-Orengo JF, Cubano L, Dharmawardhane S.

J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Feb 15;981-982:19-26. doi: 10.1016/j.jchromb.2014.12.021. Epub 2015 Jan 2.


Tyrosyl phosphorylated serine-threonine kinase PAK1 is a novel regulator of prolactin-dependent breast cancer cell motility and invasion.

Hammer A, Diakonova M.

Adv Exp Med Biol. 2015;846:97-137. doi: 10.1007/978-3-319-12114-7_5. Review.


The Rac Inhibitor EHop-016 Inhibits Mammary Tumor Growth and Metastasis in a Nude Mouse Model.

Castillo-Pichardo L, Humphries-Bickley T, De La Parra C, Forestier-Roman I, Martinez-Ferrer M, Hernandez E, Vlaar C, Ferrer-Acosta Y, Washington AV, Cubano LA, Rodriguez-Orengo J, Dharmawardhane S.

Transl Oncol. 2014 Oct 24;7(5):546-55. doi: 10.1016/j.tranon.2014.07.004. eCollection 2014 Oct.


Molecular mechanism of formation of cortical opacity in CRYAAN101D transgenic mice.

Hegde SM, Srivastava K, Tiwary E, Srivastava OP.

Invest Ophthalmol Vis Sci. 2014 Aug 21;55(10):6398-408. doi: 10.1167/iovs.14-14623.


The role of p21-activated kinases in hepatocellular carcinoma metastasis.

Tse EY, Ching YP.

J Mol Signal. 2014 Aug 1;9:7. doi: 10.1186/1750-2187-9-7. eCollection 2014. Review.


Altered glutamine metabolism and therapeutic opportunities for lung cancer.

Mohamed A, Deng X, Khuri FR, Owonikoko TK.

Clin Lung Cancer. 2014 Jan;15(1):7-15. doi: 10.1016/j.cllc.2013.09.001. Epub 2013 Nov 13. Review.


Interplay of PKA and Rac: fine-tuning of Rac localization and signaling.

Bachmann VA, Bister K, Stefan E.

Small GTPases. 2013 Oct-Dec;4(4):247-51. doi: 10.4161/sgtp.27281. Epub 2013 Dec 10. Review.


PAK1 regulates breast cancer cell invasion through secretion of matrix metalloproteinases in response to prolactin and three-dimensional collagen IV.

Rider L, Oladimeji P, Diakonova M.

Mol Endocrinol. 2013 Jul;27(7):1048-64. doi: 10.1210/me.2012-1322. Epub 2013 Jun 6.


Rac3 induces a molecular pathway triggering breast cancer cell aggressiveness: differences in MDA-MB-231 and MCF-7 breast cancer cell lines.

Gest C, Joimel U, Huang L, Pritchard LL, Petit A, Dulong C, Buquet C, Hu CQ, Mirshahi P, Laurent M, Fauvel-Lafève F, Cazin L, Vannier JP, Lu H, Soria J, Li H, Varin R, Soria C.

BMC Cancer. 2013 Feb 6;13:63. doi: 10.1186/1471-2407-13-63.


Rho GTPases and their roles in cancer metabolism.

Wilson KF, Erickson JW, Antonyak MA, Cerione RA.

Trends Mol Med. 2013 Feb;19(2):74-82. doi: 10.1016/j.molmed.2012.10.011. Epub 2012 Dec 5. Review.


Targeting of Rac GTPases blocks the spread of intact human breast cancer.

Katz E, Sims AH, Sproul D, Caldwell H, Dixon MJ, Meehan RR, Harrison DJ.

Oncotarget. 2012 Jun;3(6):608-19.


Heparanase-induced GEF-H1 signaling regulates the cytoskeletal dynamics of brain metastatic breast cancer cells.

Ridgway LD, Wetzel MD, Ngo JA, Erdreich-Epstein A, Marchetti D.

Mol Cancer Res. 2012 Jun;10(6):689-702. doi: 10.1158/1541-7786.MCR-11-0534. Epub 2012 Apr 18.


Characterization of EHop-016, novel small molecule inhibitor of Rac GTPase.

Montalvo-Ortiz BL, Castillo-Pichardo L, Hernández E, Humphries-Bickley T, De la Mota-Peynado A, Cubano LA, Vlaar CP, Dharmawardhane S.

J Biol Chem. 2012 Apr 13;287(16):13228-38. doi: 10.1074/jbc.M111.334524. Epub 2012 Mar 1.

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