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Items: 1 to 20 of 331


Ufd2p synthesizes branched ubiquitin chains to promote the degradation of substrates modified with atypical chains.

Liu C, Liu W, Ye Y, Li W.

Nat Commun. 2017 Feb 6;8:14274. doi: 10.1038/ncomms14274.


Multiple UBXN family members inhibit retrovirus and lentivirus production and canonical NFκΒ signaling by stabilizing IκBα.

Hu Y, O'Boyle K, Auer J, Raju S, You F, Wang P, Fikrig E, Sutton RE.

PLoS Pathog. 2017 Feb 2;13(2):e1006187. doi: 10.1371/journal.ppat.1006187. eCollection 2017 Feb.


SAG/RBX2 E3 ligase complexes with UBCH10 and UBE2S E2s to ubiquitylate β-TrCP1 via K11-linkage for degradation.

Kuang P, Tan M, Zhou W, Zhang Q, Sun Y.

Sci Rep. 2016 Dec 2;6:37441. doi: 10.1038/srep37441.


DCUN1D3 activates SCFSKP2 ubiquitin E3 ligase activity and cell cycle progression under UV damage.

Zhang S, Huang J, Shi T, Hu F, Zhang L, Zhou PK, Ma D, Ma T, Qiu X.

Oncotarget. 2016 Sep 6;7(36):58483-58491. doi: 10.18632/oncotarget.11302.


The E3 ligase Ubr3 regulates Usher syndrome and MYH9 disorder proteins in the auditory organs of Drosophila and mammals.

Li T, Giagtzoglou N, Eberl DF, Jaiswal SN, Cai T, Godt D, Groves AK, Bellen HJ.

Elife. 2016 Jun 22;5. pii: e15258. doi: 10.7554/eLife.15258.


Point mutations in the tumor suppressor Smad4/DPC4 enhance its phosphorylation by GSK3 and reversibly inactivate TGF-β signaling.

Demagny H, De Robertis EM.

Mol Cell Oncol. 2015 Apr 14;3(1):e1025181. doi: 10.1080/23723556.2015.1025181. eCollection 2016 Jan.


The cilia-regulated proteasome and its role in the development of ciliopathies and cancer.

Gerhardt C, Leu T, Lier JM, Rüther U.

Cilia. 2016 Jun 10;5:14. doi: 10.1186/s13630-016-0035-3. eCollection 2016. Review.


The association of mammalian DREAM complex and HPV16 E7 proteins.

Rashid NN, Rothan HA, Yusoff MS.

Am J Cancer Res. 2015 Nov 15;5(12):3525-33. eCollection 2015. Review.


F-BOX proteins in cancer cachexia and muscle wasting: Emerging regulators and therapeutic opportunities.

Sukari A, Muqbil I, Mohammad RM, Philip PA, Azmi AS.

Semin Cancer Biol. 2016 Feb;36:95-104. doi: 10.1016/j.semcancer.2016.01.002. Epub 2016 Jan 21. Review.


Skp1 Independent Function of Cdc53/Cul1 in F-box Protein Homeostasis.

Mathur R, Yen JL, Kaiser P.

PLoS Genet. 2015 Dec 10;11(12):e1005727. doi: 10.1371/journal.pgen.1005727. eCollection 2015 Dec.


Gln40 deamidation blocks structural reconfiguration and activation of SCF ubiquitin ligase complex by Nedd8.

Yu C, Mao H, Novitsky EJ, Tang X, Rychnovsky SD, Zheng N, Huang L.

Nat Commun. 2015 Dec 3;6:10053. doi: 10.1038/ncomms10053.


Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21.

Zhang C, Li X, Adelmant G, Dobbins J, Geisen C, Oser MG, Wucherpfenning KW, Marto JA, Kaelin WG Jr.

Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):15372-7. doi: 10.1073/pnas.1522006112. Epub 2015 Dec 2.


The Structural Differences between a Glycoprotein Specific F-Box Protein Fbs1 and Its Homologous Protein FBG3.

Kumanomidou T, Nishio K, Takagi K, Nakagawa T, Suzuki A, Yamane T, Tokunaga F, Iwai K, Murakami A, Yoshida Y, Tanaka K, Mizushima T.

PLoS One. 2015 Oct 13;10(10):e0140366. doi: 10.1371/journal.pone.0140366. eCollection 2015.


CAR Suppresses Hepatic Gluconeogenesis by Facilitating the Ubiquitination and Degradation of PGC1α.

Gao J, Yan J, Xu M, Ren S, Xie W.

Mol Endocrinol. 2015 Nov;29(11):1558-70. doi: 10.1210/me.2015-1145. Epub 2015 Sep 25.


Actin Cytoskeletal Organization in Drosophila Germline Ring Canals Depends on Kelch Function in a Cullin-RING E3 Ligase.

Hudson AM, Mannix KM, Cooley L.

Genetics. 2015 Nov;201(3):1117-31. doi: 10.1534/genetics.115.181289. Epub 2015 Sep 16.


Regulation of Hedgehog signaling by ubiquitination.

Hsia EY, Gui Y, Zheng X.

Front Biol (Beijing). 2015 Jun;10(3):203-220.


DNA Damage Regulates Translation through β-TRCP Targeting of CReP.

Loveless TB, Topacio BR, Vashisht AA, Galaang S, Ulrich KM, Young BD, Wohlschlegel JA, Toczyski DP.

PLoS Genet. 2015 Jun 19;11(6):e1005292. doi: 10.1371/journal.pgen.1005292. eCollection 2015 Jun.


FBXO44-Mediated Degradation of RGS2 Protein Uniquely Depends on a Cullin 4B/DDB1 Complex.

Sjögren B, Swaney S, Neubig RR.

PLoS One. 2015 May 13;10(5):e0123581. doi: 10.1371/journal.pone.0123581. eCollection 2015.


Modulation of the host innate immune and inflammatory response by translocated bacterial proteins.

Asrat S, Davis KM, Isberg RR.

Cell Microbiol. 2015 Jun;17(6):785-95. doi: 10.1111/cmi.12445. Epub 2015 May 4. Review.

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