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Items: 1 to 20 of 374

1.

A PALB2-interacting domain in RNF168 couples homologous recombination to DNA break-induced chromatin ubiquitylation.

Luijsterburg MS, Typas D, Caron MC, Wiegant WW, van den Heuvel D, Boonen RA, Couturier AM, Mullenders LH, Masson JY, van Attikum H.

Elife. 2017 Feb 27;6. pii: e20922. doi: 10.7554/eLife.20922.

2.

TOPBP1Dpb11 plays a conserved role in homologous recombination DNA repair through the coordinated recruitment of 53BP1Rad9.

Liu Y, Cussiol JR, Dibitetto D, Sims JR, Twayana S, Weiss RS, Freire R, Marini F, Pellicioli A, Smolka MB.

J Cell Biol. 2017 Mar 6;216(3):623-639. doi: 10.1083/jcb.201607031. Epub 2017 Feb 22.

PMID:
28228534
3.

CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours.

Xu H, Di Antonio M, McKinney S, Mathew V, Ho B, O'Neil NJ, Santos ND, Silvester J, Wei V, Garcia J, Kabeer F, Lai D, Soriano P, Banáth J, Chiu DS, Yap D, Le DD, Ye FB, Zhang A, Thu K, Soong J, Lin SC, Tsai AH, Osako T, Algara T, Saunders DN, Wong J, Xian J, Bally MB, Brenton JD, Brown GW, Shah SP, Cescon D, Mak TW, Caldas C, Stirling PC, Hieter P, Balasubramanian S, Aparicio S.

Nat Commun. 2017 Feb 17;8:14432. doi: 10.1038/ncomms14432.

4.

Interplay with the Mre11-Rad50-Nbs1 complex and phosphorylation by GSK3β implicate human B-Myb in DNA-damage signaling.

Henrich SM, Usadel C, Werwein E, Burdova K, Janscak P, Ferrari S, Hess D, Klempnauer KH.

Sci Rep. 2017 Jan 27;7:41663. doi: 10.1038/srep41663.

5.

Phosphoglycerate mutase 1 regulates dNTP pool and promotes homologous recombination repair in cancer cells.

Qu J, Sun W, Zhong J, Lv H, Zhu M, Xu J, Jin N, Xie Z, Tan M, Lin SH, Geng M, Ding J, Huang M.

J Cell Biol. 2017 Feb;216(2):409-424. doi: 10.1083/jcb.201607008. Epub 2017 Jan 25.

PMID:
28122957
6.

PHF11 promotes DSB resection, ATR signaling, and HR.

Gong Y, Handa N, Kowalczykowski SC, de Lange T.

Genes Dev. 2017 Jan 1;31(1):46-58. doi: 10.1101/gad.291807.116. Epub 2017 Jan 23.

7.

ATPase activity tightly regulates RecA nucleofilaments to promote homologous recombination.

Zhao B, Zhang D, Li C, Yuan Z, Yu F, Zhong S, Jiang G, Yang YG, Le XC, Weinfeld M, Zhu P, Wang H.

Cell Discov. 2017 Jan 17;3:16053. doi: 10.1038/celldisc.2016.53. eCollection 2017.

8.

miR-21-mediated Radioresistance Occurs via Promoting Repair of DNA Double Strand Breaks.

Hu B, Wang X, Hu S, Ying X, Wang P, Zhang X, Wang J, Wang H, Wang Y.

J Biol Chem. 2017 Feb 24;292(8):3531-3540. doi: 10.1074/jbc.M116.772392. Epub 2017 Jan 17.

PMID:
28096467
9.

TGF-β reduces DNA ds-break repair mechanisms to heighten genetic diversity and adaptability of CD44+/CD24- cancer cells.

Pal D, Pertot A, Shirole NH, Yao Z, Anaparthy N, Garvin T, Cox H, Chang K, Rollins F, Kendall J, Edwards L, Singh VA, Stone GC, Schatz MC, Hicks J, Hannon GJ, Sordella R.

Elife. 2017 Jan 16;6. pii: e21615. doi: 10.7554/eLife.21615.

10.

The spliceosome U2 snRNP factors promote genome stability through distinct mechanisms; transcription of repair factors and R-loop processing.

Tanikawa M, Sanjiv K, Helleday T, Herr P, Mortusewicz O.

Oncogenesis. 2016 Dec 19;5(12):e280. doi: 10.1038/oncsis.2016.70.

11.

Roles of human POLD1 and POLD3 in genome stability.

Tumini E, Barroso S, -Calero CP, Aguilera A.

Sci Rep. 2016 Dec 15;6:38873. doi: 10.1038/srep38873.

12.

A phosphorylation-deubiquitination cascade regulates the BRCA2-RAD51 axis in homologous recombination.

Luo K, Li L, Li Y, Wu C, Yin Y, Chen Y, Deng M, Nowsheen S, Yuan J, Lou Z.

Genes Dev. 2016 Dec 1;30(23):2581-2595. doi: 10.1101/gad.289439.116. Epub 2016 Dec 9.

PMID:
27941124
13.

NEK8 regulates DNA damage-induced RAD51 foci formation and replication fork protection.

Abeyta A, Castella M, Jacquemont C, Taniguchi T.

Cell Cycle. 2017 Feb 16;16(4):335-347. doi: 10.1080/15384101.2016.1259038. Epub 2016 Nov 28.

14.

A Polar and Nucleotide-Dependent Mechanism of Action for RAD51 Paralogs in RAD51 Filament Remodeling.

Taylor MR, Špírek M, Jian Ma C, Carzaniga R, Takaki T, Collinson LM, Greene EC, Krejci L, Boulton SJ.

Mol Cell. 2016 Dec 1;64(5):926-939. doi: 10.1016/j.molcel.2016.10.020. Epub 2016 Nov 17.

15.

Kin17 facilitates multiple double-strand break repair pathways that govern B cell class switching.

Le MX, Haddad D, Ling AK, Li C, So CC, Chopra A, Hu R, Angulo JF, Moffat J, Martin A.

Sci Rep. 2016 Nov 17;6:37215. doi: 10.1038/srep37215.

16.

Robust homology-directed repair within mouse mammary tissue is not specifically affected by Brca2 mutation.

Kass EM, Lim PX, Helgadottir HR, Moynahan ME, Jasin M.

Nat Commun. 2016 Oct 25;7:13241. doi: 10.1038/ncomms13241.

17.

FOXM1 and STAT3 interaction confers radioresistance in glioblastoma cells.

Maachani UB, Shankavaram U, Kramp T, Tofilon PJ, Camphausen K, Tandle AT.

Oncotarget. 2016 Nov 22;7(47):77365-77377. doi: 10.18632/oncotarget.12670.

18.

Small Molecule Inhibition of the Ubiquitin-specific Protease USP2 Accelerates cyclin D1 Degradation and Leads to Cell Cycle Arrest in Colorectal Cancer and Mantle Cell Lymphoma Models.

Davis MI, Pragani R, Fox JT, Shen M, Parmar K, Gaudiano EF, Liu L, Tanega C, McGee L, Hall MD, McKnight C, Shinn P, Nelson H, Chattopadhyay D, D'Andrea AD, Auld DS, DeLucas LJ, Li Z, Boxer MB, Simeonov A.

J Biol Chem. 2016 Nov 18;291(47):24628-24640. Epub 2016 Sep 28.

PMID:
27681596
19.

A role for the p53 tumour suppressor in regulating the balance between homologous recombination and non-homologous end joining.

Moureau S, Luessing J, Harte EC, Voisin M, Lowndes NF.

Open Biol. 2016 Sep;6(9). pii: 160225.

20.

DNA damage and Repair Modify DNA methylation and Chromatin Domain of the Targeted Locus: Mechanism of allele methylation polymorphism.

Russo G, Landi R, Pezone A, Morano A, Zuchegna C, Romano A, Muller MT, Gottesman ME, Porcellini A, Avvedimento EV.

Sci Rep. 2016 Sep 15;6:33222. doi: 10.1038/srep33222.

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