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Items: 1 to 20 of 246


Differential responsiveness of MET inhibition in non-small-cell lung cancer with altered CBL.

Tan YC, Mirzapoiazova T, Won BM, Zhu L, Srivastava MK, Vokes EE, Husain AN, Batra SK, Sharma S, Salgia R.

Sci Rep. 2017 Aug 23;7(1):9192. doi: 10.1038/s41598-017-09078-4.


High glucose levels promote the proliferation of breast cancer cells through GTPases.

Hou Y, Zhou M, Xie J, Chao P, Feng Q, Wu J.

Breast Cancer (Dove Med Press). 2017 Jun 13;9:429-436. doi: 10.2147/BCTT.S135665. eCollection 2017.


The zinc finger domain of RING finger protein 141 reveals a unique RING fold.

Miyamoto K, Uechi A, Saito K.

Protein Sci. 2017 Aug;26(8):1681-1686. doi: 10.1002/pro.3201. Epub 2017 Jun 11.


Tetraspanins Function as Regulators of Cellular Signaling.

Termini CM, Gillette JM.

Front Cell Dev Biol. 2017 Apr 6;5:34. doi: 10.3389/fcell.2017.00034. eCollection 2017. Review.


MiR-30 Family Potentially Targeting PI3K-SIAH2 Predicted Interaction Network Represents a Novel Putative Theranostic Panel in Non-small Cell Lung Cancer.

Chan LW, Wang F, Meng F, Wang L, Wong SC, Au JS, Yang S, Cho WC.

Front Genet. 2017 Feb 2;8:8. doi: 10.3389/fgene.2017.00008. eCollection 2017.


Identification of a synonymous variant in TRIM59 gene for gastric cancer risk in a Chinese population.

Luo D, Wang Y, Huan X, Huang C, Yang C, Fan H, Xu Z, Yang L.

Oncotarget. 2017 Feb 14;8(7):11507-11516. doi: 10.18632/oncotarget.14075.


Tuning BRCA1 and BARD1 activity to investigate RING ubiquitin ligase mechanisms.

Stewart MD, Duncan ED, Coronado E, DaRosa PA, Pruneda JN, Brzovic PS, Klevit RE.

Protein Sci. 2017 Mar;26(3):475-483. doi: 10.1002/pro.3091. Epub 2017 Jan 23.


Casitas B-cell lymphoma (Cbl) proteins protect mammary epithelial cells from proteotoxicity of active c-Src accumulation.

Mukhopadhyay C, Triplett A, Bargar T, Heckman C, Wagner KU, Naramura M.

Proc Natl Acad Sci U S A. 2016 Dec 20;113(51):E8228-E8237. doi: 10.1073/pnas.1615677113. Epub 2016 Dec 5.


DPP9 is a novel component of the N-end rule pathway targeting the tyrosine kinase Syk.

Justa-Schuch D, Silva-Garcia M, Pilla E, Engelke M, Kilisch M, Lenz C, Möller U, Nakamura F, Urlaub H, Geiss-Friedlander R.

Elife. 2016 Sep 10;5. pii: e16370. doi: 10.7554/eLife.16370.


Casitas B-lineage lymphoma linker helix mutations found in myeloproliferative neoplasms affect conformation.

Buetow L, Tria G, Ahmed SF, Hock A, Dou H, Sibbet GJ, Svergun DI, Huang DT.

BMC Biol. 2016 Sep 8;14:76. doi: 10.1186/s12915-016-0298-6.


The Ubiquitin Ligases c-Cbl and Cbl-b Negatively Regulate Platelet-derived Growth Factor (PDGF) BB-induced Chemotaxis by Affecting PDGF Receptor β (PDGFRβ) Internalization and Signaling.

Rorsman C, Tsioumpekou M, Heldin CH, Lennartsson J.

J Biol Chem. 2016 May 27;291(22):11608-18. doi: 10.1074/jbc.M115.705814. Epub 2016 Apr 5.


JMJ24 targets CHROMOMETHYLASE3 for proteasomal degradation in Arabidopsis.

Deng S, Jang IC, Su L, Xu J, Chua NH.

Genes Dev. 2016 Feb 1;30(3):251-6. doi: 10.1101/gad.274647.115. Epub 2016 Jan 21.


Ubiquitylation as a Rheostat for TCR Signaling: From Targeted Approaches Toward Global Profiling.

O'Leary CE, Lewis EL, Oliver PM.

Front Immunol. 2015 Dec 16;6:618. doi: 10.3389/fimmu.2015.00618. eCollection 2015. Review.


Insights into Ubiquitination from the Unique Clamp-like Binding of the RING E3 AO7 to the E2 UbcH5B.

Li S, Liang YH, Mariano J, Metzger MB, Stringer DK, Hristova VA, Li J, Randazzo PA, Tsai YC, Ji X, Weissman AM.

J Biol Chem. 2015 Dec 18;290(51):30225-39. doi: 10.1074/jbc.M115.685867. Epub 2015 Oct 16.


Comparative Analysis of Transmembrane Regulators of the Filamentous Growth Mitogen-Activated Protein Kinase Pathway Uncovers Functional and Regulatory Differences.

Adhikari H, Caccamise LM, Pande T, Cullen PJ.

Eukaryot Cell. 2015 Sep;14(9):868-83. doi: 10.1128/EC.00085-15. Epub 2015 Jun 26.


Smad7 Modulates Epidermal Growth Factor Receptor Turnover through Sequestration of c-Cbl.

Ha Thi HT, Kim HY, Choi SW, Kang JM, Kim SJ, Hong S.

Mol Cell Biol. 2015 Aug;35(16):2841-50. doi: 10.1128/MCB.00274-15. Epub 2015 Jun 8.


Mutations of c-Cbl in myeloid malignancies.

Katzav S, Schmitz ML.

Oncotarget. 2015 May 10;6(13):10689-96. Review.


The E3 ubiquitin ligase Trim7 mediates c-Jun/AP-1 activation by Ras signalling.

Chakraborty A, Diefenbacher ME, Mylona A, Kassel O, Behrens A.

Nat Commun. 2015 Apr 8;6:6782. doi: 10.1038/ncomms7782.


Modulation of Immune Cell Functions by the E3 Ligase Cbl-b.

Lutz-Nicoladoni C, Wolf D, Sopper S.

Front Oncol. 2015 Mar 11;5:58. doi: 10.3389/fonc.2015.00058. eCollection 2015. Review.


Cell regulation by phosphotyrosine-targeted ubiquitin ligases.

Cooper JA, Kaneko T, Li SS.

Mol Cell Biol. 2015 Jun 1;35(11):1886-97. doi: 10.1128/MCB.00098-15. Epub 2015 Mar 16. Review.

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