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Items: 20


WDR79 promotes the proliferation of non-small cell lung cancer cells via USP7-mediated regulation of the Mdm2-p53 pathway.

Sun Y, Cao L, Sheng X, Chen J, Zhou Y, Yang C, Deng T, Ma H, Feng P, Liu J, Tan W, Ye M.

Cell Death Dis. 2017 Apr 13;8(4):e2743. doi: 10.1038/cddis.2017.162.


Lys29-linkage of ASK1 by Skp1-Cullin 1-Fbxo21 ubiquitin ligase complex is required for antiviral innate response.

Yu Z, Chen T, Li X, Yang M, Tang S, Zhu X, Gu Y, Su X, Xia M, Li W, Zhang X, Wang Q, Cao X, Wang J.

Elife. 2016 Apr 11;5. pii: e14087. doi: 10.7554/eLife.14087.


Proteomic Study to Survey the CIGB-552 Antitumor Effect.

Rodríguez-Ulloa A, Gil J, Ramos Y, Hernández-Álvarez L, Flores L, Oliva B, García D, Sánchez-Puente A, Musacchio-Lasa A, Fernández-de-Cossio J, Padrón G, González López LJ, Besada V, Guerra-Vallespí M.

Biomed Res Int. 2015;2015:124082. doi: 10.1155/2015/124082. Epub 2015 Oct 20.


A dominant-negative F-box deleted mutant of E3 ubiquitin ligase, β-TrCP1/FWD1, markedly reduces myeloma cell growth and survival in mice.

Sharma R, Williams PJ, Gupta A, McCluskey B, Bhaskaran S, Muñoz S, Oyajobi BO.

Oncotarget. 2015 Aug 28;6(25):21589-602.


Crumbs promotes expanded recognition and degradation by the SCF(Slimb/β-TrCP) ubiquitin ligase.

Ribeiro P, Holder M, Frith D, Snijders AP, Tapon N.

Proc Natl Acad Sci U S A. 2014 May 13;111(19):E1980-9. doi: 10.1073/pnas.1315508111. Epub 2014 Apr 28.


SCF(Fbw7) modulates the NFkB signaling pathway by targeting NFkB2 for ubiquitination and destruction.

Fukushima H, Matsumoto A, Inuzuka H, Zhai B, Lau AW, Wan L, Gao D, Shaik S, Yuan M, Gygi SP, Jimi E, Asara JM, Nakayama K, Nakayama KI, Wei W.

Cell Rep. 2012 May 31;1(5):434-43.


The Fbw7 and betaTRCP E3 ubiquitin ligases and their roles in tumorigenesis.

Lau AW, Fukushima H, Wei W.

Front Biosci (Landmark Ed). 2012 Jun 1;17:2197-212. Review.


NF-κB, the first quarter-century: remarkable progress and outstanding questions.

Hayden MS, Ghosh S.

Genes Dev. 2012 Feb 1;26(3):203-34. doi: 10.1101/gad.183434.111. Review.


Inhibitor of kappa B epsilon (IκBε) is a non-redundant regulator of c-Rel-dependent gene expression in murine T and B cells.

Clark JM, Aleksiyadis K, Martin A, McNamee K, Tharmalingam T, Williams RO, Mémet S, Cope AP.

PLoS One. 2011;6(9):e24504. doi: 10.1371/journal.pone.0024504. Epub 2011 Sep 6.


Ubiquitination and degradation of the inhibitors of NF-kappaB.

Kanarek N, London N, Schueler-Furman O, Ben-Neriah Y.

Cold Spring Harb Perspect Biol. 2010 Feb;2(2):a000166. doi: 10.1101/cshperspect.a000166. Review.


Rotavirus NSP1 inhibits NFkappaB activation by inducing proteasome-dependent degradation of beta-TrCP: a novel mechanism of IFN antagonism.

Graff JW, Ettayebi K, Hardy ME.

PLoS Pathog. 2009 Jan;5(1):e1000280. doi: 10.1371/journal.ppat.1000280. Epub 2009 Jan 30.


Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer.

Frescas D, Pagano M.

Nat Rev Cancer. 2008 Jun;8(6):438-49. doi: 10.1038/nrc2396. Review.


Role of F-box protein betaTrcp1 in mammary gland development and tumorigenesis.

Kudo Y, Guardavaccaro D, Santamaria PG, Koyama-Nasu R, Latres E, Bronson R, Yamasaki L, Pagano M.

Mol Cell Biol. 2004 Sep;24(18):8184-94.


Regulation of constitutive p50/c-Rel activity via proteasome inhibitor-resistant IkappaBalpha degradation in B cells.

O'Connor S, Shumway SD, Amanna IJ, Hayes CE, Miyamoto S.

Mol Cell Biol. 2004 Jun;24(11):4895-908.


HSP27 is a ubiquitin-binding protein involved in I-kappaBalpha proteasomal degradation.

Parcellier A, Schmitt E, Gurbuxani S, Seigneurin-Berny D, Pance A, Chantôme A, Plenchette S, Khochbin S, Solary E, Garrido C.

Mol Cell Biol. 2003 Aug;23(16):5790-802.


Impaired degradation of inhibitory subunit of NF-kappa B (I kappa B) and beta-catenin as a result of targeted disruption of the beta-TrCP1 gene.

Nakayama K, Hatakeyama S, Maruyama S, Kikuchi A, Onoé K, Good RA, Nakayama KI.

Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):8752-7. Epub 2003 Jul 3.


GSK3 takes centre stage more than 20 years after its discovery.

Frame S, Cohen P.

Biochem J. 2001 Oct 1;359(Pt 1):1-16. Review.


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