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Items: 1 to 20 of 28


LncRNAs2Pathways: Identifying the pathways influenced by a set of lncRNAs of interest based on a global network propagation method.

Han J, Liu S, Sun Z, Zhang Y, Zhang F, Zhang C, Shang D, Yang H, Su F, Xu Y, Li C, Ren H, Li X.

Sci Rep. 2017 Apr 20;7:46566. doi: 10.1038/srep46566.


Cross-Talk between Cancer Cells and the Tumour Microenvironment: The Role of the 5-Lipoxygenase Pathway.

Moore GY, Pidgeon GP.

Int J Mol Sci. 2017 Jan 24;18(2). pii: E236. doi: 10.3390/ijms18020236. Review.


Convergence of eicosanoid and integrin biology: Role of Src in 12-LOX activation.

Dilly AK, Tang K, Guo Y, Joshi S, Ekambaram P, Maddipati KR, Cai Y, Tucker SC, Honn KV.

Exp Cell Res. 2017 Feb 1;351(1):1-10. doi: 10.1016/j.yexcr.2016.12.011. Epub 2016 Dec 20.


Identification and Characterization of a New Protein Isoform of Human 5-Lipoxygenase.

Häfner AK, Beilstein K, Graab P, Ball AK, Saul MJ, Hofmann B, Steinhilber D.

PLoS One. 2016 Nov 17;11(11):e0166591. doi: 10.1371/journal.pone.0166591. eCollection 2016.


Deletion of 5-Lipoxygenase in the Tumor Microenvironment Promotes Lung Cancer Progression and Metastasis through Regulating T Cell Recruitment.

Poczobutt JM, Nguyen TT, Hanson D, Li H, Sippel TR, Weiser-Evans MC, Gijon M, Murphy RC, Nemenoff RA.

J Immunol. 2016 Jan 15;196(2):891-901. doi: 10.4049/jimmunol.1501648. Epub 2015 Dec 11.


Advanced pancreatic adenocarcinoma: a review of current treatment strategies and developing therapies.

Teague A, Lim KH, Wang-Gillam A.

Ther Adv Med Oncol. 2015 Mar;7(2):68-84. doi: 10.1177/1758834014564775. Review.


Ablation of 5-lipoxygenase mitigates pancreatic lesion development.

Knab LM, Schultz M, Principe DR, Mascarinas WE, Gounaris E, Munshi HG, Grippo PJ, Bentrem DJ.

J Surg Res. 2015 Apr;194(2):481-7. doi: 10.1016/j.jss.2014.10.021. Epub 2014 Oct 22.


Involvement of eicosanoids in the pathogenesis of pancreatic cancer: the roles of cyclooxygenase-2 and 5-lipoxygenase.

Knab LM, Grippo PJ, Bentrem DJ.

World J Gastroenterol. 2014 Aug 21;20(31):10729-39. doi: 10.3748/wjg.v20.i31.10729. Review.


Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies.

Rai G, Joshi N, Jung JE, Liu Y, Schultz L, Yasgar A, Perry S, Diaz G, Zhang Q, Kenyon V, Jadhav A, Simeonov A, Lo EH, van Leyen K, Maloney DJ, Holman TR.

J Med Chem. 2014 May 22;57(10):4035-48. doi: 10.1021/jm401915r. Epub 2014 May 13.


Methyl jasmonate: putative mechanisms of action on cancer cells cycle, metabolism, and apoptosis.

Cesari IM, Carvalho E, Figueiredo Rodrigues M, Mendonça Bdos S, Amôedo ND, Rumjanek FD.

Int J Cell Biol. 2014;2014:572097. doi: 10.1155/2014/572097. Epub 2014 Feb 6. Review.


The Kaposi's sarcoma-associated herpesvirus (KSHV)-induced 5-lipoxygenase-leukotriene B4 cascade plays key roles in KSHV latency, monocyte recruitment, and lipogenesis.

Sharma-Walia N, Chandran K, Patel K, Veettil MV, Marginean A.

J Virol. 2014 Feb;88(4):2131-56. doi: 10.1128/JVI.02786-13. Epub 2013 Dec 11. Erratum in: J Virol. 2014 May;88(9):5206.


Baicalein selectively induces apoptosis in activated lymphocytes and ameliorates concanavalin a-induced hepatitis in mice.

Zhang Y, Shan L, Hua Y, Wang D, Zeng H, Liu R, Zhang W, Hu Z.

PLoS One. 2013 Jul 22;8(7):e69592. doi: 10.1371/journal.pone.0069592. Print 2013. Erratum in: PLoS One. 2015;10(1):e0117635.


Cancer-produced metabolites of 5-lipoxygenase induce tumor-evoked regulatory B cells via peroxisome proliferator-activated receptor α.

Wejksza K, Lee-Chang C, Bodogai M, Bonzo J, Gonzalez FJ, Lehrmann E, Becker K, Biragyn A.

J Immunol. 2013 Mar 15;190(6):2575-84. doi: 10.4049/jimmunol.1201920. Epub 2013 Feb 13.


Lipoxygenase and Cyclooxygenase Pathways and Colorectal Cancer Prevention.

Rao CV, Janakiram NB, Mohammed A.

Curr Colorectal Cancer Rep. 2012 Dec;8(4):316-324.


Baicalein--an intriguing therapeutic phytochemical in pancreatic cancer.

Donald G, Hertzer K, Eibl G.

Curr Drug Targets. 2012 Dec;13(14):1772-6. Review.


Up-regulation of 12(S)-lipoxygenase induces a migratory phenotype in colorectal cancer cells.

Klampfl T, Bogner E, Bednar W, Mager L, Massudom D, Kalny I, Heinzle C, Berger W, Stättner S, Karner J, Klimpfinger M, Fürstenberger G, Krieg P, Marian B.

Exp Cell Res. 2012 Apr 1;318(6):768-78. doi: 10.1016/j.yexcr.2011.12.017. Epub 2011 Dec 29.


5-lipoxygenase: underappreciated role of a pro-inflammatory enzyme in tumorigenesis.

Steinhilber D, Fischer AS, Metzner J, Steinbrink SD, Roos J, Ruthardt M, Maier TJ.

Front Pharmacol. 2010 Dec 24;1:143. doi: 10.3389/fphar.2010.00143. eCollection 2010.


Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase.

Kenyon V, Rai G, Jadhav A, Schultz L, Armstrong M, Jameson JB 2nd, Perry S, Joshi N, Bougie JM, Leister W, Taylor-Fishwick DA, Nadler JL, Holinstat M, Simeonov A, Maloney DJ, Holman TR.

J Med Chem. 2011 Aug 11;54(15):5485-97. doi: 10.1021/jm2005089. Epub 2011 Jul 8.


Discovery of potent and selective inhibitors of human reticulocyte 15-lipoxygenase-1.

Rai G, Kenyon V, Jadhav A, Schultz L, Armstrong M, Jameson JB, Hoobler E, Leister W, Simeonov A, Holman TR, Maloney DJ.

J Med Chem. 2010 Oct 28;53(20):7392-404. doi: 10.1021/jm1008852.


5-Lipoxygenase inhibitors induce potent anti-proliferative and cytotoxic effects in human tumour cells independently of suppression of 5-lipoxygenase activity.

Fischer AS, Metzner J, Steinbrink SD, Ulrich S, Angioni C, Geisslinger G, Steinhilber D, Maier TJ.

Br J Pharmacol. 2010 Oct;161(4):936-49. doi: 10.1111/j.1476-5381.2010.00915.x.

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