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Molecular mechanisms underlying the evolution of the slp76 signalosome.

Qu X, Lan X, Deng C, Zhou J, Du J, Huang S, Li Y.

Sci Rep. 2017 May 4;7(1):1509. doi: 10.1038/s41598-017-01660-0.


Crystal Structures and Thermodynamic Analysis Reveal Distinct Mechanisms of CD28 Phosphopeptide Binding to the Src Homology 2 (SH2) Domains of Three Adaptor Proteins.

Inaba S, Numoto N, Ogawa S, Morii H, Ikura T, Abe R, Ito N, Oda M.

J Biol Chem. 2017 Jan 20;292(3):1052-1060. doi: 10.1074/jbc.M116.755173. Epub 2016 Dec 6.


An extra dimension in protein tagging by quantifying universal proteotypic peptides using targeted proteomics.

Vandemoortele G, Staes A, Gonnelli G, Samyn N, De Sutter D, Vandermarliere E, Timmerman E, Gevaert K, Martens L, Eyckerman S.

Sci Rep. 2016 Jun 6;6:27220. doi: 10.1038/srep27220.


CD28 Costimulation: From Mechanism to Therapy.

Esensten JH, Helou YA, Chopra G, Weiss A, Bluestone JA.

Immunity. 2016 May 17;44(5):973-88. doi: 10.1016/j.immuni.2016.04.020. Review.


Expression of GADS enhances FLT3-induced mitogenic signaling.

Chougule RA, Cordero E, Moharram SA, Pietras K, Rönnstrand L, Kazi JU.

Oncotarget. 2016 Mar 22;7(12):14112-24. doi: 10.18632/oncotarget.7415.


GADS is required for TCR-mediated calcium influx and cytokine release, but not cellular adhesion, in human T cells.

Bilal MY, Zhang EY, Dinkel B, Hardy D, Yankee TM, Houtman JC.

Cell Signal. 2015 Apr;27(4):841-50. doi: 10.1016/j.cellsig.2015.01.012. Epub 2015 Jan 28.


The combined loss of Gads and CD127 reveals a novel function of Gads prior to TCRβ expression.

Xiong J, Parker BL, Yankee TM.

Immunol Res. 2014 Oct;60(1):77-84. doi: 10.1007/s12026-014-8556-6.


Signaling at the immune synapse: vesicular trafficking takes the stage.

Masi G, Baldari CT.

Cell Mol Immunol. 2013 Nov;10(6):459-62. doi: 10.1038/cmi.2013.42. Epub 2013 Sep 16. No abstract available.


Gads (Grb2-related adaptor downstream of Shc) is required for BCR-ABL-mediated lymphoid leukemia.

Gillis LC, Berry DM, Minden MD, McGlade CJ, Barber DL.

Leukemia. 2013 Aug;27(8):1666-76. doi: 10.1038/leu.2013.40. Epub 2013 Feb 12.


The SH2 domain-containing proteins in 21 species establish the provenance and scope of phosphotyrosine signaling in eukaryotes.

Liu BA, Shah E, Jablonowski K, Stergachis A, Engelmann B, Nash PD.

Sci Signal. 2011 Dec 6;4(202):ra83. doi: 10.1126/scisignal.2002105.


Gads regulates the expansion phase of CD8+ T cell-mediated immunity.

Zhang EY, Parker BL, Yankee TM.

J Immunol. 2011 Apr 15;186(8):4579-89. doi: 10.4049/jimmunol.1001604. Epub 2011 Mar 16.


Histidine domain-protein tyrosine phosphatase interacts with Grb2 and GrpL.

Tanase CA.

PLoS One. 2010 Dec 15;5(12):e14339. doi: 10.1371/journal.pone.0014339.


Understanding signal integration through targeted mutations of an adapter protein.

Zou T, May RM, Koretzky GA.

FEBS Lett. 2010 Dec 15;584(24):4901-9. doi: 10.1016/j.febslet.2010.10.025. Epub 2010 Oct 21.


Varying expression of four genes sharing a common regulatory sequence may differentiate rheumatoid arthritis from ageing effects on the CD4(+) lymphocytes.

Soroczyńska-Cybula M, Bryl E, Smoleńska Z, Witkowski JM.

Immunology. 2011 Jan;132(1):78-86. doi: 10.1111/j.1365-2567.2010.03341.x. Epub 2010 Aug 25.


Coordination of receptor signaling in multiple hematopoietic cell lineages by the adaptor protein SLP-76.

Jordan MS, Koretzky GA.

Cold Spring Harb Perspect Biol. 2010 Apr;2(4):a002501. doi: 10.1101/cshperspect.a002501. Epub 2010 Mar 17. Review.


The importance of Src homology 2 domain-containing leukocyte phosphoprotein of 76 kilodaltons sterile-alpha motif domain in thymic selection and T-cell activation.

Shen S, Lau J, Zhu M, Zou J, Fuller D, Li QJ, Zhang W.

Blood. 2009 Jul 2;114(1):74-84. doi: 10.1182/blood-2008-09-177832. Epub 2009 Apr 28.


The essential role of LAT in thymocyte development during transition from the double-positive to single-positive stage.

Shen S, Zhu M, Lau J, Chuck M, Zhang W.

J Immunol. 2009 May 1;182(9):5596-604. doi: 10.4049/jimmunol.0803170.


Gads-deficient thymocytes are blocked at the transitional single positive CD4+ stage.

Dalheimer SL, Zeng L, Draves KE, Hassaballa A, Jiwa NN, Parrish TD, Clark EA, Yankee TM.

Eur J Immunol. 2009 May;39(5):1395-404. doi: 10.1002/eji.200838692. Erratum in: Eur J Immunol. 2014 Dec;44(12):3768.


LAT and NTAL mediate immunoglobulin E-induced sustained extracellular signal-regulated kinase activation critical for mast cell survival.

Yamasaki S, Ishikawa E, Sakuma M, Kanagawa O, Cheng AM, Malissen B, Saito T.

Mol Cell Biol. 2007 Jun;27(12):4406-15. Epub 2007 Apr 9.


Evidence for the requirement of ITAM domains but not SLP-76/Gads interaction for integrin signaling in hematopoietic cells.

Abtahian F, Bezman N, Clemens R, Sebzda E, Cheng L, Shattil SJ, Kahn ML, Koretzky GA.

Mol Cell Biol. 2006 Sep;26(18):6936-49.

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