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Items: 1 to 20 of 45


NF-κB Pathways in the Pathogenesis of Multiple Sclerosis and the Therapeutic Implications.

Leibowitz SM, Yan J.

Front Mol Neurosci. 2016 Sep 15;9:84. eCollection 2016. Review.


Emerging Roles for Noncanonical NF-κB Signaling in the Modulation of Inflammatory Bowel Disease Pathobiology.

McDaniel DK, Eden K, Ringel VM, Allen IC.

Inflamm Bowel Dis. 2016 Sep;22(9):2265-79. doi: 10.1097/MIB.0000000000000858.


Loss of NDRG2 enhanced activation of the NF-κB pathway by PTEN and NIK phosphorylation for ATL and other cancer development.

Ichikawa T, Nakahata S, Fujii M, Iha H, Morishita K.

Sci Rep. 2015 Aug 13;5:12841. doi: 10.1038/srep12841.


Tumor progression locus 2 (Tpl2) kinase as a novel therapeutic target for cancer: double-sided effects of Tpl2 on cancer.

Lee HW, Choi HY, Joo KM, Nam DH.

Int J Mol Sci. 2015 Feb 25;16(3):4471-91. doi: 10.3390/ijms16034471. Review.


Aberrant expression of COT is related to recurrence of papillary thyroid cancer.

Lee J, Jeong S, Park JH, Lee CR, Ku CR, Kang SW, Jeong JJ, Nam KH, Shin DY, Lee EJ, Chung WY, Jo YS.

Medicine (Baltimore). 2015 Feb;94(6):e548. doi: 10.1097/MD.0000000000000548.


Intestinal myofibroblast-specific Tpl2-Cox-2-PGE2 pathway links innate sensing to epithelial homeostasis.

Roulis M, Nikolaou C, Kotsaki E, Kaffe E, Karagianni N, Koliaraki V, Salpea K, Ragoussis J, Aidinis V, Martini E, Becker C, Herschman HR, Vetrano S, Danese S, Kollias G.

Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):E4658-67. doi: 10.1073/pnas.1415762111. Epub 2014 Oct 14.


A CD4+ T cell antagonist epitope down-regulates activating signaling proteins, up-regulates inhibitory signaling proteins and abrogates HIV-specific T cell function.

Jacobs ES, Persad D, Ran L, Danesh A, Heitman JW, Deng X, Cameron MJ, Kelvin DJ, Norris PJ.

Retrovirology. 2014 Jul 5;11:57. doi: 10.1186/1742-4690-11-57.


RelB-induced expression of Cot, an MAP3K family member, rescues RANKL-induced osteoclastogenesis in alymphoplasia mice by promoting NF-κB2 processing by IKKα.

Taniguchi R, Fukushima H, Osawa K, Maruyama T, Yasuda H, Weih F, Doi T, Maki K, Jimi E.

J Biol Chem. 2014 Mar 14;289(11):7349-61. doi: 10.1074/jbc.M113.538314. Epub 2014 Jan 31.


IκB kinase 2 regulates TPL-2 activation of extracellular signal-regulated kinases 1 and 2 by direct phosphorylation of TPL-2 serine 400.

Roget K, Ben-Addi A, Mambole-Dema A, Gantke T, Yang HT, Janzen J, Morrice N, Abbott D, Ley SC.

Mol Cell Biol. 2012 Nov;32(22):4684-90. doi: 10.1128/MCB.01065-12. Epub 2012 Sep 17.


Cot kinase promotes Ca2+ oscillation/calcineurin-independent osteoclastogenesis by stabilizing NFATc1 protein.

Kuroda Y, Hisatsune C, Mizutani A, Ogawa N, Matsuo K, Mikoshiba K.

Mol Cell Biol. 2012 Jul;32(14):2954-63. doi: 10.1128/MCB.05611-11. Epub 2012 May 21.


Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinase.

Gantke T, Sriskantharajah S, Ley SC.

Cell Res. 2011 Jan;21(1):131-45. doi: 10.1038/cr.2010.173. Epub 2010 Dec 7. Review. Erratum in: Cell Res. 2011 Apr;21(4):704.


A novel pentamethoxyflavone down-regulates tumor cell survival and proliferative and angiogenic gene products through inhibition of IκB kinase activation and sensitizes tumor cells to apoptosis by cytokines and chemotherapeutic agents.

Phromnoi K, Reuter S, Sung B, Prasad S, Kannappan R, Yadav VR, Chanmahasathien W, Limtrakul P, Aggarwal BB.

Mol Pharmacol. 2011 Feb;79(2):279-89. doi: 10.1124/mol.110.067512. Epub 2010 Oct 7.


NF-κB inducing kinase: a key regulator in the immune system and in cancer.

Thu YM, Richmond A.

Cytokine Growth Factor Rev. 2010 Aug;21(4):213-26. doi: 10.1016/j.cytogfr.2010.06.002. Epub 2010 Aug 3. Review.


An enigmatic tail of CD28 signaling.

Boomer JS, Green JM.

Cold Spring Harb Perspect Biol. 2010 Aug;2(8):a002436. doi: 10.1101/cshperspect.a002436. Epub 2010 Jun 9. Review.


Combinatorial signals from CD28 differentially regulate human immunodeficiency virus transcription in T cells.

Natarajan M, August A, Henderson AJ.

J Biol Chem. 2010 Jun 4;285(23):17338-47. doi: 10.1074/jbc.M109.085324. Epub 2010 Apr 5.


Comparison of peptide array substrate phosphorylation of c-Raf and mitogen activated protein kinase kinase kinase 8.

Parikh K, Diks SH, Tuynman JH, Verhaar A, Löwenberg M, Hommes DW, Joore J, Pandey A, Peppelenbosch MP.

PLoS One. 2009 Jul 30;4(7):e6440. doi: 10.1371/journal.pone.0006440.


BCL11B enhances TCR/CD28-triggered NF-kappaB activation through up-regulation of Cot kinase gene expression in T-lymphocytes.

Cismasiu VB, Duque J, Paskaleva E, Califano D, Ghanta S, Young HA, Avram D.

Biochem J. 2009 Jan 15;417(2):457-66. doi: 10.1042/BJ20080925.


Functional genomic delineation of TLR-induced transcriptional networks.

Elkon R, Linhart C, Halperin Y, Shiloh Y, Shamir R.

BMC Genomics. 2007 Oct 29;8:394.


A comprehensive map of the toll-like receptor signaling network.

Oda K, Kitano H.

Mol Syst Biol. 2006;2:2006.0015. Epub 2006 Apr 18. Review.


The inhibitory effect of alendronate, a nitrogen-containing bisphosphonate on the PI3K-Akt-NFkappaB pathway in osteosarcoma cells.

Inoue R, Matsuki NA, Jing G, Kanematsu T, Abe K, Hirata M.

Br J Pharmacol. 2005 Nov;146(5):633-41.

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