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Items: 1 to 20 of 231

1.

Glucagon receptor inhibition normalizes blood glucose in severe insulin-resistant mice.

Okamoto H, Cavino K, Na E, Krumm E, Kim SY, Cheng X, Murphy AJ, Yancopoulos GD, Gromada J.

Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2753-2758. doi: 10.1073/pnas.1621069114. Epub 2017 Jan 23.

PMID:
28115707
2.

Glucose and fatty acids synergistically and reversibly promote beta cell proliferation in rats.

Moullé VS, Vivot K, Tremblay C, Zarrouki B, Ghislain J, Poitout V.

Diabetologia. 2017 May;60(5):879-888. doi: 10.1007/s00125-016-4197-8. Epub 2017 Jan 11.

PMID:
28078385
3.

Adipocyte Dynamics and Reversible Metabolic Syndrome in Mice with an Inducible Adipocyte-Specific Deletion of the Insulin Receptor.

Sakaguchi M, Fujisaka S, Cai W, Winnay JN, Konishi M, O'Neill BT, Li M, García-Martín R, Takahashi H, Hu J, Kulkarni RN, Kahn CR.

Cell Metab. 2017 Feb 7;25(2):448-462. doi: 10.1016/j.cmet.2016.12.008. Epub 2017 Jan 5.

PMID:
28065828
4.

Hypothalamic AMP-Activated Protein Kinase Regulates Biphasic Insulin Secretion from Pancreatic ? Cells during Fasting and in Type 2 Diabetes.

Kume S, Kondo M, Maeda S, Nishio Y, Yanagimachi T, Fujita Y, Haneda M, Kondo K, Sekine A, Araki SI, Araki H, Chin-Kanasaki M, Ugi S, Koya D, Kitahara S, Maeda K, Kashiwagi A, Uzu T, Maegawa H.

EBioMedicine. 2016 Nov;13:168-180. doi: 10.1016/j.ebiom.2016.10.038. Epub 2016 Oct 28.

5.

Insulin receptor isoform A ameliorates long-term glucose intolerance in diabetic mice.

Diaz-Castroverde S, Gómez-Hernández A, Fernández S, García-Gómez G, Di Scala M, González-Aseguinolaza G, Fernández-Millán E, González-Rodríguez Á, García-Bravo M, Chambon P, Álvarez C, Perdomo L, Beneit N, Escribano O, Benito M.

Dis Model Mech. 2016 Nov 1;9(11):1271-1281. Epub 2016 Aug 24.

6.

Nuclear Export of FoxO1 Is Associated with ERK Signaling in β-Cells Lacking Insulin Receptors.

Mezza T, Shirakawa J, Martinez R, Hu J, Giaccari A, Kulkarni RN.

J Biol Chem. 2016 Oct 7;291(41):21485-21495. Epub 2016 Aug 17.

PMID:
27535223
7.

Insulin receptor alternative splicing is regulated by insulin signaling and modulates beta cell survival.

Malakar P, Chartarifsky L, Hija A, Leibowitz G, Glaser B, Dor Y, Karni R.

Sci Rep. 2016 Aug 16;6:31222. doi: 10.1038/srep31222.

8.

Visceral adiposity syndrome.

Lopes HF, Corrêa-Giannella ML, Consolim-Colombo FM, Egan BM.

Diabetol Metab Syndr. 2016 Jul 19;8:40. doi: 10.1186/s13098-016-0156-2. eCollection 2016. Review.

9.

Application of network construction to estimate functional changes to insulin receptor substrates 1 and 2 in Huh7 cells following infection with the hepatitis C virus.

Liu J, Wang L, Wang W, Li Y, Jia X, Zhai S, Shi J, Dang S.

Mol Med Rep. 2016 Sep;14(3):2379-88. doi: 10.3892/mmr.2016.5527. Epub 2016 Jul 18.

10.

Lipodystrophy and severe metabolic dysfunction in mice with adipose tissue-specific insulin receptor ablation.

Qiang G, Whang Kong H, Xu S, Pham HA, Parlee SD, Burr AA, Gil V, Pang J, Hughes A, Gu X, Fantuzzi G, MacDougald OA, Liew CW.

Mol Metab. 2016 May 14;5(7):480-90. doi: 10.1016/j.molmet.2016.05.005. eCollection 2016 Jul.

11.

PI3 kinases p110α and PI3K-C2β negatively regulate cAMP via PDE3/8 to control insulin secretion in mouse and human islets.

Kolic J, Manning Fox JE, Chepurny OG, Spigelman AF, Ferdaoussi M, Schwede F, Holz GG, MacDonald PE.

Mol Metab. 2016 May 11;5(7):459-71. doi: 10.1016/j.molmet.2016.05.003. eCollection 2016 Jul.

12.

β-cell insulin receptor deficiency during in utero development induces an islet compensatory overgrowth response.

Trinder M, Zhou L, Oakie A, Riopel M, Wang R.

Oncotarget. 2016 Jul 19;7(29):44927-44940. doi: 10.18632/oncotarget.10342.

13.

Suppressors of Cytokine Signaling in Sickness and in Health of Pancreatic β-Cells.

Ye C, Driver JP.

Front Immunol. 2016 May 9;7:169. doi: 10.3389/fimmu.2016.00169. eCollection 2016. Review.

14.

Using Drosophila to discover mechanisms underlying type 2 diabetes.

Alfa RW, Kim SK.

Dis Model Mech. 2016 Apr;9(4):365-76. doi: 10.1242/dmm.023887. Review.

15.

Generation of CRISPR/Cas9-mediated bicistronic knock-in ins1-cre driver mice.

Hasegawa Y, Hoshino Y, Ibrahim AE, Kato K, Daitoku Y, Tanimoto Y, Ikeda Y, Oishi H, Takahashi S, Yoshiki A, Yagami K, Iseki H, Mizuno S, Sugiyama F.

Exp Anim. 2016 Jul 29;65(3):319-27. doi: 10.1538/expanim.16-0016. Epub 2016 Apr 7.

16.

Cannabinoids Regulate Bcl-2 and Cyclin D2 Expression in Pancreatic β Cells.

Kim J, Lee KJ, Kim JS, Rho JG, Shin JJ, Song WK, Lee EK, Egan JM, Kim W.

PLoS One. 2016 Mar 11;11(3):e0150981. doi: 10.1371/journal.pone.0150981. eCollection 2016.

17.

Fibroblast Growth Factor 21 (FGF21) Protects against High Fat Diet Induced Inflammation and Islet Hyperplasia in Pancreas.

Singhal G, Fisher FM, Chee MJ, Tan TG, El Ouaamari A, Adams AC, Najarian R, Kulkarni RN, Benoist C, Flier JS, Maratos-Flier E.

PLoS One. 2016 Feb 12;11(2):e0148252. doi: 10.1371/journal.pone.0148252. eCollection 2016.

18.

Glucose Induces Mouse β-Cell Proliferation via IRS2, MTOR, and Cyclin D2 but Not the Insulin Receptor.

Stamateris RE, Sharma RB, Kong Y, Ebrahimpour P, Panday D, Ranganath P, Zou B, Levitt H, Parambil NA, O'Donnell CP, García-Ocaña A, Alonso LC.

Diabetes. 2016 Apr;65(4):981-95. doi: 10.2337/db15-0529. Epub 2016 Jan 6.

19.

Increased Glucose-induced Secretion of Glucagon-like Peptide-1 in Mice Lacking the Carcinoembryonic Antigen-related Cell Adhesion Molecule 2 (CEACAM2).

Ghanem SS, Heinrich G, Lester SG, Pfeiffer V, Bhattacharya S, Patel PR, DeAngelis AM, Dai T, Ramakrishnan SK, Smiley ZN, Jung DY, Lee Y, Kitamura T, Ergun S, Kulkarni RN, Kim JK, Giovannucci DR, Najjar SM.

J Biol Chem. 2016 Jan 8;291(2):980-8. doi: 10.1074/jbc.M115.692582. Epub 2015 Nov 19.

20.

Insulin exerts direct, IGF-1 independent actions in growth plate chondrocytes.

Zhang F, He Q, Tsang WP, Garvey WT, Chan WY, Wan C.

Bone Res. 2014 Jul 1;2:14012. doi: 10.1038/boneres.2014.12. eCollection 2014.

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