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Items: 1 to 20 of 161

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Active site analysis of 17beta-hydroxysteroid dehydrogenase type 1 enzyme complexes with SPROUT.

Alho-Richmond S, Lilienkampf A, Wähälä K.

Mol Cell Endocrinol. 2006 Mar 27;248(1-2):208-13. Epub 2006 Jan 10.

PMID:
16412556
5.

Structural basis for species specific inhibition of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1): computational study and biological validation.

Klein T, Henn C, Negri M, Frotscher M.

PLoS One. 2011;6(8):e22990. doi: 10.1371/journal.pone.0022990. Epub 2011 Aug 9.

6.

Crystallization and preliminary crystal structure of the complex of 17beta-hydroxysteroid dehydrogenase with a dual-site inhibitor.

Zhu DW, Campbell R, Labrie F, Lin SX.

J Steroid Biochem Mol Biol. 1999 Sep-Oct;70(4-6):229-35.

PMID:
10622412
7.

Crystal structure of human type III 3alpha-hydroxysteroid dehydrogenase/bile acid binding protein complexed with NADP(+) and ursodeoxycholate.

Jin Y, Stayrook SE, Albert RH, Palackal NT, Penning TM, Lewis M.

Biochemistry. 2001 Aug 28;40(34):10161-8.

PMID:
11513593
8.

Structural basis of the multispecificity demonstrated by 17beta-hydroxysteroid dehydrogenase types 1 and 5.

Lin SX, Shi R, Qiu W, Azzi A, Zhu DW, Dabbagh HA, Zhou M.

Mol Cell Endocrinol. 2006 Mar 27;248(1-2):38-46. Epub 2006 Feb 15. Review.

PMID:
16480815
9.

The regulation and inhibition of 17beta-hydroxysteroid dehydrogenase in breast cancer.

Purohit A, Tutill HJ, Day JM, Chander SK, Lawrence HR, Allan GM, Fischer DS, Vicker N, Newman SP, Potter BV, Reed MJ.

Mol Cell Endocrinol. 2006 Mar 27;248(1-2):199-203. Epub 2006 Jan 18.

PMID:
16414180
10.

Unusual charge stabilization of NADP+ in 17beta-hydroxysteroid dehydrogenase.

Mazza C, Breton R, Housset D, Fontecilla-Camps JC.

J Biol Chem. 1998 Apr 3;273(14):8145-52.

11.

Biochemical factors governing the steady-state estrone/estradiol ratios catalyzed by human 17beta-hydroxysteroid dehydrogenases types 1 and 2 in HEK-293 cells.

Sherbet DP, Guryev OL, Papari-Zareei M, Mizrachi D, Rambally S, Akbar S, Auchus RJ.

Endocrinology. 2009 Sep;150(9):4154-62. doi: 10.1210/en.2008-1817. Epub 2009 Jun 25.

12.

17beta-hydroxysteroid dehydrogenase type 1 stimulates breast cancer by dihydrotestosterone inactivation in addition to estradiol production.

Aka JA, Mazumdar M, Chen CQ, Poirier D, Lin SX.

Mol Endocrinol. 2010 Apr;24(4):832-45. doi: 10.1210/me.2009-0468. Epub 2010 Feb 19.

PMID:
20172961
13.

Structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase at 2.20 A resolution.

Ghosh D, Pletnev VZ, Zhu DW, Wawrzak Z, Duax WL, Pangborn W, Labrie F, Lin SX.

Structure. 1995 May 15;3(5):503-13.

PMID:
7663947
14.
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Insights in 17beta-HSD1 enzyme kinetics and ligand binding by dynamic motion investigation.

Negri M, Recanatini M, Hartmann RW.

PLoS One. 2010 Aug 10;5(8):e12026. doi: 10.1371/journal.pone.0012026.

16.

Two non-reactive ternary complexes of estrogenic 17beta-hydroxysteroid dehydrogenase: crystallization and preliminary structural analysis.

Qiu W, Zhu DW, Azzi A, Campbell RL, Qi H, Poirier D, Lin SX.

J Steroid Biochem Mol Biol. 1999 Mar;68(5-6):239-44.

PMID:
10416839
17.

Synthesis and biological evaluation of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) inhibitors based on a thieno[2,3-d]pyrimidin-4(3H)-one core.

Lilienkampf A, Karkola S, Alho-Richmond S, Koskimies P, Johansson N, Huhtinen K, Vihko K, Wähälä K.

J Med Chem. 2009 Nov 12;52(21):6660-71. doi: 10.1021/jm900928k.

PMID:
19824648
18.

Bicyclic substituted hydroxyphenylmethanone type inhibitors of 17 β-hydroxysteroid dehydrogenase Type 1 (17 β-HSD1): the role of the bicyclic moiety.

Oster A, Klein T, Henn C, Werth R, Marchais-Oberwinkler S, Frotscher M, Hartmann RW.

ChemMedChem. 2011 Mar 7;6(3):476-87. doi: 10.1002/cmdc.201000457. Epub 2011 Feb 17.

PMID:
21337522
19.

Crystal structure of murine 11 beta-hydroxysteroid dehydrogenase 1: an important therapeutic target for diabetes.

Zhang J, Osslund TD, Plant MH, Clogston CL, Nybo RE, Xiong F, Delaney JM, Jordan SR.

Biochemistry. 2005 May 10;44(18):6948-57.

PMID:
15865440
20.

17beta-hydroxysteroid dehydrogenase Type 1, and not Type 12, is a target for endocrine therapy of hormone-dependent breast cancer.

Day JM, Foster PA, Tutill HJ, Parsons MF, Newman SP, Chander SK, Allan GM, Lawrence HR, Vicker N, Potter BV, Reed MJ, Purohit A.

Int J Cancer. 2008 May 1;122(9):1931-40. doi: 10.1002/ijc.23350.

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