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Items: 1 to 20 of 120

1.

Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene.

Poltorak A, He X, Smirnova I, Liu MY, Van Huffel C, Du X, Birdwell D, Alejos E, Silva M, Galanos C, Freudenberg M, Ricciardi-Castagnoli P, Layton B, Beutler B.

Science. 1998 Dec 11;282(5396):2085-8.

2.

Monoallelic expression of the murine gene encoding Toll-like receptor 4.

Pereira JP, Girard R, Chaby R, Cumano A, Vieira P.

Nat Immunol. 2003 May;4(5):464-70. Epub 2003 Mar 31.

PMID:
12665857
3.

Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4)

Qureshi ST, Larivière L, Leveque G, Clermont S, Moore KJ, Gros P, Malo D.

J Exp Med. 1999 Feb 15;189(4):615-25. Erratum in: J Exp Med 1999 May 3;189(9):following 1518.

4.

Positional cloning of Lps, and the general role of toll-like receptors in the innate immune response.

Beutler B, Poltorak A.

Eur Cytokine Netw. 2000 Jun;11(2):143-52. Review.

5.

Induction of TNF-alpha and MnSOD by endotoxin: role of membrane CD14 and Toll-like receptor-4.

Tsan MF, Clark RN, Goyert SM, White JE.

Am J Physiol Cell Physiol. 2001 Jun;280(6):C1422-30.

6.

Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product.

Hoshino K, Takeuchi O, Kawai T, Sanjo H, Ogawa T, Takeda Y, Takeda K, Akira S.

J Immunol. 1999 Apr 1;162(7):3749-52.

7.

Limits of a deletion spanning Tlr4 in C57BL/10ScCr mice.

Poltorak A, Smirnova I, Clisch R, Beutler B.

J Endotoxin Res. 2000;6(1):51-6.

PMID:
11061032
8.
9.

Cutting edge: functional characterization of the effect of the C3H/HeJ defect in mice that lack an Lpsn gene: in vivo evidence for a dominant negative mutation.

Vogel SN, Johnson D, Perera PY, Medvedev A, Larivière L, Qureshi ST, Malo D.

J Immunol. 1999 May 15;162(10):5666-70.

10.

Toll-like receptor 4 is not required for the full maturation of dendritic cells or for the degradation of Gram-negative bacteria.

Rescigno M, Urbano M, Rimoldi M, Valzasina B, Rotta G, Granucci F, Ricciardi-Castagnoli P.

Eur J Immunol. 2002 Oct;32(10):2800-6.

11.

Endotoxin, toll-like receptor 4, and the afferent limb of innate immunity.

Beutler B.

Curr Opin Microbiol. 2000 Feb;3(1):23-8. Review.

PMID:
10679425
12.

TLR4 mutations are associated with endotoxin hyporesponsiveness in humans.

Arbour NC, Lorenz E, Schutte BC, Zabner J, Kline JN, Jones M, Frees K, Watt JL, Schwartz DA.

Nat Genet. 2000 Jun;25(2):187-91.

PMID:
10835634
13.

Protective roles of mast cells against enterobacterial infection are mediated by Toll-like receptor 4.

Supajatura V, Ushio H, Nakao A, Okumura K, Ra C, Ogawa H.

J Immunol. 2001 Aug 15;167(4):2250-6.

15.

Genes other than TLR4 are involved in the response to inhaled LPS.

Lorenz E, Jones M, Wohlford-Lenane C, Meyer N, Frees KL, Arbour NC, Schwartz DA.

Am J Physiol Lung Cell Mol Physiol. 2001 Nov;281(5):L1106-14.

16.

Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells.

Paik YH, Schwabe RF, Bataller R, Russo MP, Jobin C, Brenner DA.

Hepatology. 2003 May;37(5):1043-55.

PMID:
12717385
17.

Endotoxin-mimetic effect of antibodies against Toll-like receptor 4.

Nattermann J, Du X, Wei Y, Shevchenko D, Beutler B.

J Endotoxin Res. 2000;6(3):257-64.

PMID:
11052181
18.
19.

Analysis of Tlr4-mediated LPS signal transduction in macrophages by mutational modification of the receptor.

Du X, Poltorak A, Silva M, Beutler B.

Blood Cells Mol Dis. 1999 Oct-Dec;25(5-6):328-38. Erratum in: Blood Cells Mol Dis 2000 Feb;26(1):9.

PMID:
10660480
20.

LPS-hyporesponsiveness of mnd mice is associated with a mutation in Toll-like receptor 4.

Bihl F, Larivière L, Qureshi ST, Flaherty L, Malo D.

Genes Immun. 2001 Feb;2(1):56-9.

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