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Adenoviral transgene expression of MMAC/PTEN in human glioma cells inhibits Akt activation and induces anoikis.

Davies MA, Lu Y, Sano T, Fang X, Tang P, LaPushin R, Koul D, Bookstein R, Stokoe D, Yung WK, Mills GB, Steck PA.

Cancer Res. 1998 Dec 1;58(23):5285-90. Erratum in: Cancer Res 1999 Mar 1;59(5):1167.


Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC.

Haas-Kogan D, Shalev N, Wong M, Mills G, Yount G, Stokoe D.

Curr Biol. 1998 Oct 22;8(21):1195-8.


MMAC1/PTEN inhibits cell growth and induces chemosensitivity to doxorubicin in human bladder cancer cells.

Tanaka M, Koul D, Davies MA, Liebert M, Steck PA, Grossman HB.

Oncogene. 2000 Nov 9;19(47):5406-12.


Adenoviral-mediated expression of MMAC/PTEN inhibits proliferation and metastasis of human prostate cancer cells.

Davies MA, Kim SJ, Parikh NU, Dong Z, Bucana CD, Gallick GE.

Clin Cancer Res. 2002 Jun;8(6):1904-14.


PTEN gene therapy induces growth inhibition and increases efficacy of chemotherapy in prostate cancer.

Tanaka M, Rosser CJ, Grossman HB.

Cancer Detect Prev. 2005;29(2):170-4. Epub 2004 Dec 10.


MDA-7 regulates cell growth and radiosensitivity in vitro of primary (non-established) human glioma cells.

Yacoub A, Mitchell C, Hong Y, Gopalkrishnan RV, Su ZZ, Gupta P, Sauane M, Lebedeva IV, Curiel DT, Mahasreshti PJ, Rosenfeld MR, Broaddus WC, James CD, Grant S, Fisher PB, Dent P.

Cancer Biol Ther. 2004 Aug;3(8):739-51. Epub 2004 Aug 10.


Inhibition of ILK in PTEN-mutant human glioblastomas inhibits PKB/Akt activation, induces apoptosis, and delays tumor growth.

Edwards LA, Thiessen B, Dragowska WH, Daynard T, Bally MB, Dedhar S.

Oncogene. 2005 May 19;24(22):3596-605.


The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-kappaB and c-Myc in pancreatic cancer cells.

Asano T, Yao Y, Zhu J, Li D, Abbruzzese JL, Reddy SA.

Oncogene. 2004 Nov 11;23(53):8571-80. Erratum in: Oncogene. 2005 Jun 16;24(26)4320.


Regulation of Akt/PKB activity, cellular growth, and apoptosis in prostate carcinoma cells by MMAC/PTEN.

Davies MA, Koul D, Dhesi H, Berman R, McDonnell TJ, McConkey D, Yung WK, Steck PA.

Cancer Res. 1999 Jun 1;59(11):2551-6.


Suppression of matrix metalloproteinase-2 gene expression and invasion in human glioma cells by MMAC/PTEN.

Koul D, Parthasarathy R, Shen R, Davies MA, Jasser SA, Chintala SK, Rao JS, Sun Y, Benvenisite EN, Liu TJ, Yung WK.

Oncogene. 2001 Oct 11;20(46):6669-78.


PTEN, but not SHIP and SHIP2, suppresses the PI3K/Akt pathway and induces growth inhibition and apoptosis of myeloma cells.

Choi Y, Zhang J, Murga C, Yu H, Koller E, Monia BP, Gutkind JS, Li W.

Oncogene. 2002 Aug 8;21(34):5289-300.


PTEN gene transfer in human malignant glioma: sensitization to irradiation and CD95L-induced apoptosis.

Wick W, Furnari FB, Naumann U, Cavenee WK, Weller M.

Oncogene. 1999 Jul 8;18(27):3936-43.


Adenoviral-mediated expression of a kinase-dead mutant of Akt induces apoptosis selectively in tumor cells and suppresses tumor growth in mice.

Jetzt A, Howe JA, Horn MT, Maxwell E, Yin Z, Johnson D, Kumar CC.

Cancer Res. 2003 Oct 15;63(20):6697-706.


The tumor suppressor PTEN regulates T cell survival and antigen receptor signaling by acting as a phosphatidylinositol 3-phosphatase.

Wang X, Gjörloff-Wingren A, Saxena M, Pathan N, Reed JC, Mustelin T.

J Immunol. 2000 Feb 15;164(4):1934-9.


Differential expression of MMAC/PTEN in glioblastoma multiforme: relationship to localization and prognosis.

Sano T, Lin H, Chen X, Langford LA, Koul D, Bondy ML, Hess KR, Myers JN, Hong YK, Yung WK, Steck PA.

Cancer Res. 1999 Apr 15;59(8):1820-4.


Biological role of phosphatase PTEN in cancer and tissue injury healing.

Tsugawa K, Jones MK, Sugimachi K, Sarfeh IJ, Tarnawski AS.

Front Biosci. 2002 May 1;7:e245-51. Review.


Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells.

Persad S, Attwell S, Gray V, Delcommenne M, Troussard A, Sanghera J, Dedhar S.

Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3207-12.


Adenovirus-mediated transfer of the PTEN gene inhibits human colorectal cancer growth in vitro and in vivo.

Saito Y, Swanson X, Mhashilkar AM, Oida Y, Schrock R, Branch CD, Chada S, Zumstein L, Ramesh R.

Gene Ther. 2003 Nov;10(23):1961-9.


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