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Items: 1 to 20 of 530

1.

Multiple human cytochromes contribute to biotransformation of dextromethorphan in-vitro: role of CYP2C9, CYP2C19, CYP2D6, and CYP3A.

von Moltke LL, Greenblatt DJ, Grassi JM, Granda BW, Venkatakrishnan K, Schmider J, Harmatz JS, Shader RI.

J Pharm Pharmacol. 1998 Sep;50(9):997-1004.

PMID:
9811160
2.

Metabolism of dextromethorphan in vitro: involvement of cytochromes P450 2D6 and 3A3/4, with a possible role of 2E1.

Schmider J, Greenblatt DJ, Fogelman SM, von Moltke LL, Shader RI.

Biopharm Drug Dispos. 1997 Apr;18(3):227-40.

PMID:
9113345
3.

Kinetic characterization and identification of the enzymes responsible for the hepatic biotransformation of adinazolam and N-desmethyladinazolam in man.

Venkatakrishnan K, von Moltke LL, Duan SX, Fleishaker JC, Shader RI, Greenblatt DJ.

J Pharm Pharmacol. 1998 Mar;50(3):265-74.

PMID:
9600717
4.

Relative contributions of CYP2C9 and 2C19 to phenytoin 4-hydroxylation in vitro: inhibition by sulfaphenazole, omeprazole, and ticlopidine.

Giancarlo GM, Venkatakrishnan K, Granda BW, von Moltke LL, Greenblatt DJ.

Eur J Clin Pharmacol. 2001 Apr;57(1):31-6.

PMID:
11372587
5.
7.

Cytochrome P-450 enzymes and FMO3 contribute to the disposition of the antipsychotic drug perazine in vitro.

Störmer E, Brockmöller J, Roots I, Schmider J.

Psychopharmacology (Berl). 2000 Sep;151(4):312-20.

PMID:
11026737
8.

Variable contribution of cytochromes P450 2D6, 2C9 and 3A4 to the 4-hydroxylation of tamoxifen by human liver microsomes.

Crewe HK, Ellis SW, Lennard MS, Tucker GT.

Biochem Pharmacol. 1997 Jan 24;53(2):171-8.

PMID:
9037249
9.

Metabolism of 7-benzyloxy-4-trifluoromethyl-coumarin by human hepatic cytochrome P450 isoforms.

Renwick AB, Surry D, Price RJ, Lake BG, Evans DC.

Xenobiotica. 2000 Oct;30(10):955-69.

PMID:
11315104
10.

Cytochrome P450 2C9 catalyzes indomethacin O-demethylation in human liver microsomes.

Nakajima M, Inoue T, Shimada N, Tokudome S, Yamamoto T, Kuroiwa Y.

Drug Metab Dispos. 1998 Mar;26(3):261-6.

11.
12.

The role of CYP2C in the in vitro bioactivation of the contraceptive steroid desogestrel.

Gentile DM, Verhoeven CH, Shimada T, Back DJ.

J Pharmacol Exp Ther. 1998 Dec;287(3):975-82.

13.

O- and N-demethylation of venlafaxine in vitro by human liver microsomes and by microsomes from cDNA-transfected cells: effect of metabolic inhibitors and SSRI antidepressants.

Fogelman SM, Schmider J, Venkatakrishnan K, von Moltke LL, Harmatz JS, Shader RI, Greenblatt DJ.

Neuropsychopharmacology. 1999 May;20(5):480-90.

14.
15.

Identification of human cytochrome P450 isoforms involved in the metabolism of S-2-[4-(3-methyl-2-thienyl)phenyl]propionic acid.

Taguchi K, Konishi T, Nishikawa H, Kitamura S.

Xenobiotica. 1999 Sep;29(9):899-907.

PMID:
10548450
16.
17.

Five distinct human cytochromes mediate amitriptyline N-demethylation in vitro: dominance of CYP 2C19 and 3A4.

Venkatakrishnan K, Greenblatt DJ, von Moltke LL, Schmider J, Harmatz JS, Shader RI.

J Clin Pharmacol. 1998 Feb;38(2):112-21.

PMID:
9549641
18.

Gemfibrozil is a potent inhibitor of human cytochrome P450 2C9.

Wen X, Wang JS, Backman JT, Kivistö KT, Neuvonen PJ.

Drug Metab Dispos. 2001 Nov;29(11):1359-61.

19.

CYP3A4 is the major CYP isoform mediating the in vitro hydroxylation and demethylation of flunitrazepam.

Hesse LM, Venkatakrishnan K, von Moltke LL, Shader RI, Greenblatt DJ.

Drug Metab Dispos. 2001 Feb;29(2):133-40.

20.

Lack of single-dose disulfiram effects on cytochrome P-450 2C9, 2C19, 2D6, and 3A4 activities: evidence for specificity toward P-450 2E1.

Kharasch ED, Hankins DC, Jubert C, Thummel KE, Taraday JK.

Drug Metab Dispos. 1999 Jun;27(6):717-23.

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