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Items: 1 to 20 of 109

1.

Crystal structure of the first three domains of the type-1 insulin-like growth factor receptor.

Garrett TP, McKern NM, Lou M, Frenkel MJ, Bentley JD, Lovrecz GO, Elleman TC, Cosgrove LJ, Ward CW.

Nature. 1998 Jul 23;394(6691):395-9.

PMID:
9690478
2.

Solution structure of ectodomains of the insulin receptor family: the ectodomain of the type 1 insulin-like growth factor receptor displays asymmetry of ligand binding accompanied by limited conformational change.

Whitten AE, Smith BJ, Menting JG, Margetts MB, McKern NM, Lovrecz GO, Adams TE, Richards K, Bentley JD, Trewhella J, Ward CW, Lawrence MC.

J Mol Biol. 2009 Dec 18;394(5):878-92. doi: 10.1016/j.jmb.2009.10.011. Epub 2009 Oct 14.

PMID:
19835884
3.

Insulin receptor structure and its implications for the IGF-1 receptor.

Lawrence MC, McKern NM, Ward CW.

Curr Opin Struct Biol. 2007 Dec;17(6):699-705. Epub 2007 Sep 11. Review.

PMID:
17851071
4.

Characterization of a comparative model of the extracellular domain of the epidermal growth factor receptor.

Jorissen RN, Epa VC, Treutlein HR, Garrett TP, Ward CW, Burgess AW.

Protein Sci. 2000 Feb;9(2):310-24.

5.

The three dimensional structure of the type I insulin-like growth factor receptor.

Ward CW, Garrett TP, McKern NM, Lou M, Cosgrove LJ, Sparrow LG, Frenkel MJ, Hoyne PA, Elleman TC, Adams TE, Lovrecz GO, Lawrence LJ, Tulloch PA.

Mol Pathol. 2001 Jun;54(3):125-32. Review.

6.

Structure of the insulin receptor ectodomain reveals a folded-over conformation.

McKern NM, Lawrence MC, Streltsov VA, Lou MZ, Adams TE, Lovrecz GO, Elleman TC, Richards KM, Bentley JD, Pilling PA, Hoyne PA, Cartledge KA, Pham TM, Lewis JL, Sankovich SE, Stoichevska V, Da Silva E, Robinson CP, Frenkel MJ, Sparrow LG, Fernley RT, Epa VC, Ward CW.

Nature. 2006 Sep 14;443(7108):218-21. Epub 2006 Sep 6.

PMID:
16957736
7.

Characterization of ligand binding of a soluble human insulin-like growth factor I receptor variant suggests a ligand-induced conformational change.

Jansson M, Hallén D, Koho H, Andersson G, Berghard L, Heidrich J, Nyberg E, Uhlén M, Kördel J, Nilsson B.

J Biol Chem. 1997 Mar 28;272(13):8189-97.

8.

Alanine scanning mutagenesis of a type 1 insulin-like growth factor receptor ligand binding site.

Whittaker J, Groth AV, Mynarcik DC, Pluzek L, Gadsbøll VL, Whittaker LJ.

J Biol Chem. 2001 Nov 23;276(47):43980-6. Epub 2001 Aug 10.

9.

Structural insights into ligand-induced activation of the insulin receptor.

Ward C, Lawrence M, Streltsov V, Garrett T, McKern N, Lou MZ, Lovrecz G, Adams T.

Acta Physiol (Oxf). 2008 Jan;192(1):3-9. doi: 10.1111/j.1748-1716.2007.01781.x. Review.

PMID:
18171424
10.

Crystallization of the first three domains of the human insulin-like growth factor-1 receptor.

McKern NM, Lou M, Frenkel MJ, Verkuylen A, Bentley JD, Lovrecz GO, Ivancic N, Elleman TC, Garrett TP, Cosgrove LJ, Ward CW.

Protein Sci. 1997 Dec;6(12):2663-6.

12.

Insulin and insulin-like growth factor-1 binding specificity is determined by distinct regions of their cognate receptors.

Schumacher R, Mosthaf L, Schlessinger J, Brandenburg D, Ullrich A.

J Biol Chem. 1991 Oct 15;266(29):19288-95.

13.

An investigation of the ligand binding properties and negative cooperativity of soluble insulin-like growth factor receptors.

Surinya KH, Forbes BE, Occhiodoro F, Booker GW, Francis GL, Siddle K, Wallace JC, Cosgrove LJ.

J Biol Chem. 2008 Feb 29;283(9):5355-63. Epub 2007 Dec 3.

14.
15.

Complex with a phage display-derived peptide provides insight into the function of insulin-like growth factor I.

Schaffer ML, Deshayes K, Nakamura G, Sidhu S, Skelton NJ.

Biochemistry. 2003 Aug 12;42(31):9324-34.

PMID:
12899619
17.

Insulin and insulin-like growth factor-1 receptors in an evoluted fish, the turbot: cDNA cloning and mRNA expression.

Eliès G, Duval H, Bonnec G, Wolff J, Boeuf G, Boujard D.

Mol Cell Endocrinol. 1999 Dec 20;158(1-2):173-85.

PMID:
10630417
18.

Positively charged side chains in the insulin-like growth factor-1 C- and D-regions determine receptor binding specificity.

Zhang W, Gustafson TA, Rutter WJ, Johnson JD.

J Biol Chem. 1994 Apr 8;269(14):10609-13.

19.

A third fibronectin type III domain in the extracellular region of the insulin receptor family.

Marino-Buslje C, Mizuguchi K, Siddle K, Blundell TL.

FEBS Lett. 1998 Dec 18;441(2):331-6.

20.

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