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Items: 1 to 20 of 152

1.

A targeted point mutation in thrombomodulin generates viable mice with a prethrombotic state.

Weiler-Guettler H, Christie PD, Beeler DL, Healy AM, Hancock WW, Rayburn H, Edelberg JM, Rosenberg RD.

J Clin Invest. 1998 May 1;101(9):1983-91.

2.

The thrombomodulin-protein C system is essential for the maintenance of pregnancy.

Isermann B, Sood R, Pawlinski R, Zogg M, Kalloway S, Degen JL, Mackman N, Weiler H.

Nat Med. 2003 Mar;9(3):331-7. Epub 2003 Feb 10.

PMID:
12579195
3.

Effects on coagulation and fibrinolysis induced by influenza in mice with a reduced capacity to generate activated protein C and a deficiency in plasminogen activator inhibitor type 1.

Keller TT, van der Sluijs KF, de Kruif MD, Gerdes VE, Meijers JC, Florquin S, van der Poll T, van Gorp EC, Brandjes DP, Büller HR, Levi M.

Circ Res. 2006 Nov 24;99(11):1261-9. Epub 2006 Oct 26.

4.

Kit/stem cell factor receptor-induced activation of phosphatidylinositol 3'-kinase is essential for male fertility.

Blume-Jensen P, Jiang G, Hyman R, Lee KF, O'Gorman S, Hunter T.

Nat Genet. 2000 Feb;24(2):157-62.

PMID:
10655061
6.

Endothelium-specific loss of murine thrombomodulin disrupts the protein C anticoagulant pathway and causes juvenile-onset thrombosis.

Isermann B, Hendrickson SB, Zogg M, Wing M, Cummiskey M, Kisanuki YY, Yanagisawa M, Weiler H.

J Clin Invest. 2001 Aug;108(4):537-46.

7.

Thrombin, thrombomodulin and TAFI in the molecular link between coagulation and fibrinolysis.

Nesheim M, Wang W, Boffa M, Nagashima M, Morser J, Bajzar L.

Thromb Haemost. 1997 Jul;78(1):386-91. Review.

PMID:
9198184
8.

Role of the vascular endothelial growth factor isoforms in retinal angiogenesis and DiGeorge syndrome.

Stalmans I.

Verh K Acad Geneeskd Belg. 2005;67(4):229-76. Review.

PMID:
16334858
9.

Structure-function analyses of thrombomodulin by gene-targeting in mice: the cytoplasmic domain is not required for normal fetal development.

Conway EM, Pollefeyt S, Cornelissen J, DeBaere I, Steiner-Mosonyi M, Weitz JI, Weiler-Guettler H, Carmeliet P, Collen D.

Blood. 1999 May 15;93(10):3442-50.

10.
11.

Fetal gene defects precipitate platelet-mediated pregnancy failure in factor V Leiden mothers.

Sood R, Zogg M, Westrick RJ, Guo YH, Kerschen EJ, Girardi G, Salmon JE, Coughlin SR, Weiler H.

J Exp Med. 2007 May 14;204(5):1049-56. Epub 2007 Apr 16.

12.

Endothelial cell protein C receptor plays an important role in protein C activation in vivo.

Taylor FB Jr, Peer GT, Lockhart MS, Ferrell G, Esmon CT.

Blood. 2001 Mar 15;97(6):1685-8.

13.

Platelet factor 4 modulation of the thrombomodulin-protein C system.

Slungaard A.

Crit Care Med. 2004 May;32(5 Suppl):S331-5. Review.

PMID:
15118540
14.

PECAM-1 modulates thrombin-induced tissue factor expression on endothelial cells.

Zhang JJ, Kelm RJ, Biswas P, Kashgarian M, Madri JA.

J Cell Physiol. 2007 Feb;210(2):527-37.

PMID:
17111362
15.

Amino acid residues in the P6-P'3 region of thrombin-activable fibrinolysis inhibitor (TAFI) do not determine the thrombomodulin dependence of TAFI activation.

Schneider M, Nagashima M, Knappe S, Zhao L, Morser J, Nesheim M.

J Biol Chem. 2002 Mar 22;277(12):9944-51. Epub 2002 Jan 10.

16.

Regulation of blood coagulation by the protein C anticoagulant pathway: novel insights into structure-function relationships and molecular recognition.

Dahlbäck B, Villoutreix BO.

Arterioscler Thromb Vasc Biol. 2005 Jul;25(7):1311-20. Epub 2005 Apr 28. Review.

17.

Functional thrombomodulin deficiency causes enhanced thrombus growth in a murine model of carotid artery thrombosis.

Dörffler-Melly J, de Kruif M, Schwarte LA, Franco RF, Florquin S, Spek CA, Ince C, Reitsma PH, ten Cate H.

Basic Res Cardiol. 2003 Nov;98(6):347-52. Epub 2003 May 12.

PMID:
14556079
18.

The effect of aprotinin on activated protein C-mediated downregulation of endogenous thrombin generation.

Tanaka KA, Szlam F, Levy JH.

Br J Haematol. 2006 Jul;134(1):77-82.

PMID:
16803571
19.

Life-threatening thrombosis in mice with targeted Arg48-to-Cys mutation of the heparin-binding domain of antithrombin.

Dewerchin M, Hérault JP, Wallays G, Petitou M, Schaeffer P, Millet L, Weitz JI, Moons L, Collen D, Carmeliet P, Herbert JM.

Circ Res. 2003 Nov 28;93(11):1120-6. Epub 2003 Oct 30.

20.

Characterization of a mouse model for thrombomodulin deficiency.

Weiler H, Lindner V, Kerlin B, Isermann BH, Hendrickson SB, Cooley BC, Meh DA, Mosesson MW, Shworak NW, Post MJ, Conway EM, Ulfman LH, von Andrian UH, Weitz JI.

Arterioscler Thromb Vasc Biol. 2001 Sep;21(9):1531-7.

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