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Interleukin-6 and related cytokines: effect on the acute phase reaction.

Heinrich PC, Horn F, Graeve L, Dittrich E, Kerr I, Müller-Newen G, Grötzinger J, Wollmer A.

Z Ernahrungswiss. 1998;37 Suppl 1:43-9. Review.


Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway.

Heinrich PC, Behrmann I, Müller-Newen G, Schaper F, Graeve L.

Biochem J. 1998 Sep 1;334 ( Pt 2):297-314. Review.


Signal transduction of IL-6, leukemia-inhibitory factor, and oncostatin M: structural receptor requirements for signal attenuation.

Anhuf D, Weissenbach M, Schmitz J, Sobota R, Hermanns HM, Radtke S, Linnemann S, Behrmann I, Heinrich PC, Schaper F.

J Immunol. 2000 Sep 1;165(5):2535-43.


STAT3 activation by cytokines utilizing gp130 and related transducers involves a secondary modification requiring an H7-sensitive kinase.

Boulton TG, Zhong Z, Wen Z, Darnell JE Jr, Stahl N, Yancopoulos GD.

Proc Natl Acad Sci U S A. 1995 Jul 18;92(15):6915-9.


Activation of the signal transducer glycoprotein 130 by both IL-6 and IL-11 requires two distinct binding epitopes.

Kurth I, Horsten U, Pflanz S, Dahmen H, Küster A, Grötzinger J, Heinrich PC, Müller-Newen G.

J Immunol. 1999 Feb 1;162(3):1480-7.


Principles of interleukin (IL)-6-type cytokine signalling and its regulation.

Heinrich PC, Behrmann I, Haan S, Hermanns HM, Müller-Newen G, Schaper F.

Biochem J. 2003 Aug 15;374(Pt 1):1-20. Review.


Oncostatin M regulates the synthesis and turnover of gp130, leukemia inhibitory factor receptor alpha, and oncostatin M receptor beta by distinct mechanisms.

Blanchard F, Wang Y, Kinzie E, Duplomb L, Godard A, Baumann H.

J Biol Chem. 2001 Dec 14;276(50):47038-45. Epub 2001 Oct 15.


Characterization of the Interleukin (IL)-6 Inhibitor IL-6-RFP: fused receptor domains act as high affinity cytokine-binding proteins.

Metz S, Wiesinger M, Vogt M, Lauks H, Schmalzing G, Heinrich PC, Müller-Newen G.

J Biol Chem. 2007 Jan 12;282(2):1238-48. Epub 2006 Nov 3.


Receptor recognition sites of cytokines are organized as exchangeable modules. Transfer of the leukemia inhibitory factor receptor-binding site from ciliary neurotrophic factor to interleukin-6.

Kallen KJ, Grötzinger J, Lelièvre E, Vollmer P, Aasland D, Renné C, Müllberg J, Myer zum Büschenfelde KH, Gascan H, Rose-John S.

J Biol Chem. 1999 Apr 23;274(17):11859-67.


Interleukin-6 and oncostatin M-induced growth inhibition of human A375 melanoma cells is STAT-dependent and involves upregulation of the cyclin-dependent kinase inhibitor p27/Kip1.

Kortylewski M, Heinrich PC, Mackiewicz A, Schniertshauer U, Klingmüller U, Nakajima K, Hirano T, Horn F, Behrmann I.

Oncogene. 1999 Jun 24;18(25):3742-53.


Characterization of soluble gp130 released by melanoma cell lines: A polyvalent antagonist of cytokines from the interleukin 6 family.

Montero-Julian FA, Brailly H, Sautès C, Joyeux I, Dorval T, Mosseri V, Yasukawa K, Wijdenes J, Adler A, Gorin I, Fridman WH, Tartour E.

Clin Cancer Res. 1997 Aug;3(8):1443-51.


Modulation of hepatic acute phase gene expression by epidermal growth factor and Src protein tyrosine kinases in murine and human hepatic cells.

Wang Y, Ripperger J, Fey GH, Samols D, Kordula T, Wetzler M, Van Etten RA, Baumann H.

Hepatology. 1999 Sep;30(3):682-97.


Activation of the signal transducer gp130 by interleukin-11 and interleukin-6 is mediated by similar molecular interactions.

Dahmen H, Horsten U, Küster A, Jacques Y, Minvielle S, Kerr IM, Ciliberto G, Paonessa G, Heinrich PC, Müller-Newen G.

Biochem J. 1998 May 1;331 ( Pt 3):695-702.

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