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Items: 1 to 20 of 120

1.

Disruption of IRS-2 causes type 2 diabetes in mice.

Withers DJ, Gutierrez JS, Towery H, Burks DJ, Ren JM, Previs S, Zhang Y, Bernal D, Pons S, Shulman GI, Bonner-Weir S, White MF.

Nature. 1998 Feb 26;391(6670):900-4.

PMID:
9495343
2.

Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

Kubota N, Tobe K, Terauchi Y, Eto K, Yamauchi T, Suzuki R, Tsubamoto Y, Komeda K, Nakano R, Miki H, Satoh S, Sekihara H, Sciacchitano S, Lesniak M, Aizawa S, Nagai R, Kimura S, Akanuma Y, Taylor SI, Kadowaki T.

Diabetes. 2000 Nov;49(11):1880-9.

PMID:
11078455
3.

Insulin signalling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice.

Yamauchi T, Tobe K, Tamemoto H, Ueki K, Kaburagi Y, Yamamoto-Honda R, Takahashi Y, Yoshizawa F, Aizawa S, Akanuma Y, Sonenberg N, Yazaki Y, Kadowaki T.

Mol Cell Biol. 1996 Jun;16(6):3074-84.

4.

Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2.

Kido Y, Burks DJ, Withers D, Bruning JC, Kahn CR, White MF, Accili D.

J Clin Invest. 2000 Jan;105(2):199-205.

5.

Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling.

Withers DJ, Burks DJ, Towery HH, Altamuro SL, Flint CL, White MF.

Nat Genet. 1999 Sep;23(1):32-40.

PMID:
10471495
6.

[Insulin signaling and pathophysiology of type 2 diabetes mellitus].

Ogawa W, Kasuga M.

Nihon Rinsho. 2006 Jul;64(7):1381-9. Review. Japanese.

PMID:
16838661
7.

Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans.

Banks AS, Li J, McKeag L, Hribal ML, Kashiwada M, Accili D, Rothman PB.

J Clin Invest. 2005 Sep;115(9):2462-71. Epub 2005 Aug 25.

8.

Inducible nitric oxide synthase deficiency ameliorates skeletal muscle insulin resistance but does not alter unexpected lower blood glucose levels after burn injury in C57BL/6 mice.

Sugita M, Sugita H, Kim M, Mao J, Yasuda Y, Habiro M, Shinozaki S, Yasuhara S, Shimizu N, Martyn JA, Kaneki M.

Metabolism. 2012 Jan;61(1):127-36. doi: 10.1016/j.metabol.2011.06.001. Epub 2011 Aug 3.

9.

Impact of genetic background and ablation of insulin receptor substrate (IRS)-3 on IRS-2 knock-out mice.

Terauchi Y, Matsui J, Suzuki R, Kubota N, Komeda K, Aizawa S, Eto K, Kimura S, Nagai R, Tobe K, Lienhard GE, Kadowaki T.

J Biol Chem. 2003 Apr 18;278(16):14284-90. Epub 2002 Dec 18.

10.

Disruption of the SH2-B gene causes age-dependent insulin resistance and glucose intolerance.

Duan C, Yang H, White MF, Rui L.

Mol Cell Biol. 2004 Sep;24(17):7435-43.

11.

IRS proteins and beta-cell function.

Burks DJ, White MF.

Diabetes. 2001 Feb;50 Suppl 1:S140-5. Review.

13.

A signal for beta-cell failure.

Avruch J.

Nature. 1998 Feb 26;391(6670):846-7. No abstract available.

PMID:
9495335
15.

Alterations in growth and apoptosis of insulin receptor substrate-1-deficient beta-cells.

Hennige AM, Ozcan U, Okada T, Jhala US, Schubert M, White MF, Kulkarni RN.

Am J Physiol Endocrinol Metab. 2005 Aug;289(2):E337-46. Epub 2005 Apr 12.

PMID:
15827066
16.

Both insulin signaling defects in the liver and obesity contribute to insulin resistance and cause diabetes in Irs2(-/-) mice.

Suzuki R, Tobe K, Aoyama M, Inoue A, Sakamoto K, Yamauchi T, Kamon J, Kubota N, Terauchi Y, Yoshimatsu H, Matsuhisa M, Nagasaka S, Ogata H, Tokuyama K, Nagai R, Kadowaki T.

J Biol Chem. 2004 Jun 11;279(24):25039-49. Epub 2004 Mar 17.

17.

Insulin signal transduction in skeletal muscle from glucose-intolerant relatives of type 2 diabetic patients [corrected].

Storgaard H, Song XM, Jensen CB, Madsbad S, Björnholm M, Vaag A, Zierath JR.

Diabetes. 2001 Dec;50(12):2770-8. Erratum in: Diabetes 2002 Feb;51(2):552.

18.

Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and beta cell glucokinase genes. Genetic reconstitution of diabetes as a polygenic disease.

Terauchi Y, Iwamoto K, Tamemoto H, Komeda K, Ishii C, Kanazawa Y, Asanuma N, Aizawa T, Akanuma Y, Yasuda K, Kodama T, Tobe K, Yazaki Y, Kadowaki T.

J Clin Invest. 1997 Mar 1;99(5):861-6.

19.
20.

Regulation of IRS-2 tyrosine phosphorylation in fasting and diabetes.

Rojas FA, Hirata AE, Saad MJ.

Mol Cell Endocrinol. 2001 Oct 25;183(1-2):63-9.

PMID:
11604226

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