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Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2.

Lonergan KM, Iliopoulos O, Ohh M, Kamura T, Conaway RC, Conaway JW, Kaelin WG Jr.

Mol Cell Biol. 1998 Feb;18(2):732-41.


The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins.

Pause A, Lee S, Worrell RA, Chen DY, Burgess WH, Linehan WM, Klausner RD.

Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2156-61.


The pVHL-associated SCF ubiquitin ligase complex: molecular genetic analysis of elongin B and C, Rbx1 and HIF-1alpha in renal cell carcinoma.

Clifford SC, Astuti D, Hooper L, Maxwell PH, Ratcliffe PJ, Maher ER.

Oncogene. 2001 Aug 16;20(36):5067-74.


Synthetic peptides define critical contacts between elongin C, elongin B, and the von Hippel-Lindau protein.

Ohh M, Takagi Y, Aso T, Stebbins CE, Pavletich NP, Zbar B, Conaway RC, Conaway JW, Kaelin WG Jr.

J Clin Invest. 1999 Dec;104(11):1583-91.


The von Hippel-Lindau tumour suppressor protein: new perspectives.

Ohh M, Kaelin WG Jr.

Mol Med Today. 1999 Jun;5(6):257-63. Review.


Functions of the von Hippel-Lindau tumour suppressor protein.

Kaelin WG, Iliopoulos O, Lonergan KM, Ohh M.

J Intern Med. 1998 Jun;243(6):535-9. Review.


The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2.

Kamura T, Conrad MN, Yan Q, Conaway RC, Conaway JW.

Genes Dev. 1999 Nov 15;13(22):2928-33.


Alternate choice of initiation codon produces a biologically active product of the von Hippel Lindau gene with tumor suppressor activity.

Blankenship C, Naglich JG, Whaley JM, Seizinger B, Kley N.

Oncogene. 1999 Feb 25;18(8):1529-35.


The von Hippel-Lindau tumor suppressor protein.

Ivan M, Kaelin WG Jr.

Curr Opin Genet Dev. 2001 Feb;11(1):27-34. Review.


Characterization of Cullin-box sequences that direct recruitment of Cul2-Rbx1 and Cul5-Rbx2 modules to Elongin BC-based ubiquitin ligases.

Mahrour N, Redwine WB, Florens L, Swanson SK, Martin-Brown S, Bradford WD, Staehling-Hampton K, Washburn MP, Conaway RC, Conaway JW.

J Biol Chem. 2008 Mar 21;283(12):8005-13. doi: 10.1074/jbc.M706987200. Epub 2008 Jan 10.


Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase.

Brower CS, Sato S, Tomomori-Sato C, Kamura T, Pause A, Stearman R, Klausner RD, Malik S, Lane WS, Sorokina I, Roeder RG, Conaway JW, Conaway RC.

Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10353-8. Epub 2002 Jul 29.


Identification of Elongin C and Skp1 sequences that determine Cullin selection.

Yan Q, Kamura T, Cai Y, Jin J, Ivan M, Mushegian A, Conaway RC, Conaway JW.

J Biol Chem. 2004 Oct 8;279(41):43019-26. Epub 2004 Jul 27.


Conjugation of the ubiquitin-like protein NEDD8 to cullin-2 is linked to von Hippel-Lindau tumor suppressor function.

Liakopoulos D, Büsgen T, Brychzy A, Jentsch S, Pause A.

Proc Natl Acad Sci U S A. 1999 May 11;96(10):5510-5.


Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex.

Iwai K, Yamanaka K, Kamura T, Minato N, Conaway RC, Conaway JW, Klausner RD, Pause A.

Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12436-41.


The von Hippel-Lindau tumor suppressor protein mediates ubiquitination of activated atypical protein kinase C.

Okuda H, Saitoh K, Hirai S, Iwai K, Takaki Y, Baba M, Minato N, Ohno S, Shuin T.

J Biol Chem. 2001 Nov 23;276(47):43611-7. Epub 2001 Sep 26.


The von Hippel-Lindau protein interacts with heteronuclear ribonucleoprotein a2 and regulates its expression.

Pioli PA, Rigby WF.

J Biol Chem. 2001 Oct 26;276(43):40346-52. Epub 2001 Aug 21.

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