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Association of the multisubstrate docking protein Gab1 with the hepatocyte growth factor receptor requires a functional Grb2 binding site involving tyrosine 1356.

Nguyen L, Holgado-Madruga M, Maroun C, Fixman ED, Kamikura D, Fournier T, Charest A, Tremblay ML, Wong AJ, Park M.

J Biol Chem. 1997 Aug 15;272(33):20811-9.


Grb2-independent recruitment of Gab1 requires the C-terminal lobe and structural integrity of the Met receptor kinase domain.

Lock LS, Frigault MM, Saucier C, Park M.

J Biol Chem. 2003 Aug 8;278(32):30083-90. Epub 2003 May 22.


Efficient cellular transformation by the Met oncoprotein requires a functional Grb2 binding site and correlates with phosphorylation of the Grb2-associated proteins, Cbl and Gab1.

Fixman ED, Holgado-Madruga M, Nguyen L, Kamikura DM, Fournier TM, Wong AJ, Park M.

J Biol Chem. 1997 Aug 8;272(32):20167-72.


Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses.

Schaeper U, Gehring NH, Fuchs KP, Sachs M, Kempkes B, Birchmeier W.

J Cell Biol. 2000 Jun 26;149(7):1419-32.


The C-terminal SH3 domain of the adapter protein Grb2 binds with high affinity to sequences in Gab1 and SLP-76 which lack the SH3-typical P-x-x-P core motif.

Lewitzky M, Kardinal C, Gehring NH, Schmidt EK, Konkol B, Eulitz M, Birchmeier W, Schaeper U, Feller SM.

Oncogene. 2001 Mar 1;20(9):1052-62.


MUC20 suppresses the hepatocyte growth factor-induced Grb2-Ras pathway by binding to a multifunctional docking site of met.

Higuchi T, Orita T, Katsuya K, Yamasaki Y, Akiyama K, Li H, Yamamoto T, Saito Y, Nakamura M.

Mol Cell Biol. 2004 Sep;24(17):7456-68.


ERK negatively regulates the epidermal growth factor-mediated interaction of Gab1 and the phosphatidylinositol 3-kinase.

Yu CF, Liu ZX, Cantley LG.

J Biol Chem. 2002 May 31;277(22):19382-8. Epub 2002 Mar 14.


The multisubstrate docking site of the MET receptor is dispensable for MET-mediated RAS signaling and cell scattering.

Tulasne D, Paumelle R, Weidner KM, Vandenbunder B, Fafeur V.

Mol Biol Cell. 1999 Mar;10(3):551-65.


Potent blockade of hepatocyte growth factor-stimulated cell motility, matrix invasion and branching morphogenesis by antagonists of Grb2 Src homology 2 domain interactions.

Atabey N, Gao Y, Yao ZJ, Breckenridge D, Soon L, Soriano JV, Burke TR Jr, Bottaro DP.

J Biol Chem. 2001 Apr 27;276(17):14308-14. Epub 2001 Feb 1.


Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis.

Weidner KM, Di Cesare S, Sachs M, Brinkmann V, Behrens J, Birchmeier W.

Nature. 1996 Nov 14;384(6605):173-6.


Concomitant activation of pathways downstream of Grb2 and PI 3-kinase is required for MET-mediated metastasis.

Bardelli A, Basile ML, Audero E, Giordano S, Wennström S, Ménard S, Comoglio PM, Ponzetto C.

Oncogene. 1999 Feb 4;18(5):1139-46.


A conserved inositol phospholipid binding site within the pleckstrin homology domain of the Gab1 docking protein is required for epithelial morphogenesis.

Maroun CR, Moscatello DK, Naujokas MA, Holgado-Madruga M, Wong AJ, Park M.

J Biol Chem. 1999 Oct 29;274(44):31719-26.


Adaptor molecule Crk is required for sustained phosphorylation of Grb2-associated binder 1 and hepatocyte growth factor-induced cell motility of human synovial sarcoma cell lines.

Watanabe T, Tsuda M, Makino Y, Ichihara S, Sawa H, Minami A, Mochizuki N, Nagashima K, Tanaka S.

Mol Cancer Res. 2006 Jul;4(7):499-510.


Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL.

Sakkab D, Lewitzky M, Posern G, Schaeper U, Sachs M, Birchmeier W, Feller SM.

J Biol Chem. 2000 Apr 14;275(15):10772-8.


Coupling of Grb2 to Gab1 mediates hepatocyte growth factor-induced high intensity ERK signal required for inhibition of HepG2 hepatoma cell proliferation.

Kondo A, Hirayama N, Sugito Y, Shono M, Tanaka T, Kitamura N.

J Biol Chem. 2008 Jan 18;283(3):1428-36. Epub 2007 Nov 14.


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