Format
Sort by

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 215

1.

High resolution crystal structure of a human tumor necrosis factor-alpha mutant with low systemic toxicity.

Cha SS, Kim JS, Cho HS, Shin NK, Jeong W, Shin HC, Kim YJ, Hahn JH, Oh BH.

J Biol Chem. 1998 Jan 23;273(4):2153-60.

3.

Crystal structure of TNF-alpha mutant R31D with greater affinity for receptor R1 compared with R2.

Reed C, Fu ZQ, Wu J, Xue YN, Harrison RW, Chen MJ, Weber IT.

Protein Eng. 1997 Oct;10(10):1101-7.

4.

Structure-function relationship of tumor necrosis factor (TNF) and its receptor interaction based on 3D structural analysis of a fully active TNFR1-selective TNF mutant.

Mukai Y, Shibata H, Nakamura T, Yoshioka Y, Abe Y, Nomura T, Taniai M, Ohta T, Ikemizu S, Nakagawa S, Tsunoda S, Kamada H, Yamagata Y, Tsutsumi Y.

J Mol Biol. 2009 Jan 30;385(4):1221-9. doi: 10.1016/j.jmb.2008.11.053.

PMID:
19084540
5.

Creation and X-ray structure analysis of the tumor necrosis factor receptor-1-selective mutant of a tumor necrosis factor-alpha antagonist.

Shibata H, Yoshioka Y, Ohkawa A, Minowa K, Mukai Y, Abe Y, Taniai M, Nomura T, Kayamuro H, Nabeshi H, Sugita T, Imai S, Nagano K, Yoshikawa T, Fujita T, Nakagawa S, Yamamoto A, Ohta T, Hayakawa T, Mayumi T, Vandenabeele P, Aggarwal BB, Nakamura T, Yamagata Y, Tsunoda S, Kamada H, Tsutsumi Y.

J Biol Chem. 2008 Jan 11;283(2):998-1007.

6.

A novel tumor necrosis factor-alpha mutant with significantly enhanced cytotoxicity and receptor binding affinity.

Shin NK, Lee I, Chang SG, Shin HC.

Biochem Mol Biol Int. 1998 May;44(6):1075-82.

PMID:
9623760
7.

Human TNF mutants with selective activity on the p55 receptor.

Van Ostade X, Vandenabeele P, Everaerdt B, Loetscher H, Gentz R, Brockhaus M, Lesslauer W, Tavernier J, Brouckaert P, Fiers W.

Nature. 1993 Jan 21;361(6409):266-9.

PMID:
8380906
8.

Tumor necrosis factor mutants with selective cytotoxic activity.

Berkova N, Lemay A, Korobko V, Shingarova L, Sagaidak L, Goupil S.

Cancer Detect Prev. 1999;23(1):1-7.

PMID:
9892984
9.

Interactions between novel tumor necrosis factor-alpha mutants and receptors on tumor and normal cells.

Nakamura S, Masegi T, Fukuoka M, Kitai K, Kato A, Ichikawa Y, Watanabe N, Niitsu Y.

Agric Biol Chem. 1991 Jan;55(1):53-7.

10.

Biological activities of human tumor necrosis factor-alpha and its novel mutants.

Xi T, Shi X, Guo D, Dong X, Xu X, Zhu D.

Biochem Mol Biol Int. 1996 Apr;38(4):855-62.

PMID:
8728116
11.

Identification of tumor necrosis factor (TNF) amino acids crucial for binding to the murine p75 TNF receptor and construction of receptor-selective mutants.

Ameloot P, Fiers W, De Bleser P, Ware CF, Vandenabeele P, Brouckaert P.

J Biol Chem. 2001 Oct 5;276(40):37426-30.

12.

Minimal tumor necrosis factor receptor binding protein: optimum biological activity of a truncated p55 soluble tumor necrosis factor receptor-IgG fusion protein.

Corcoran AE, Scallon BJ, Trinh H, Chernajovsky Y, Ghrayeb J, Feldmann M.

Eur Cytokine Netw. 1998 Sep;9(3):255-62.

13.

Effect of gene transfer of tumor necrosis factor receptors into human lung carcinoma cell line.

Ohara H, Hasegawa Y, Kawabe T, Ichiyama S, Hara T, Shimono Y, Saito H, Shimokata K.

Jpn J Cancer Res. 1998 May;89(5):589-95.

PMID:
9685865
14.

An apoptosis-inducing gene therapy for pancreatic cancer with a combination of 55-kDa tumor necrosis factor (TNF) receptor gene transfection and mutein TNF administration.

Sato T, Yamauchi N, Sasaki H, Takahashi M, Okamoto T, Sakamaki S, Watanabe N, Niitsu Y.

Cancer Res. 1998 Apr 15;58(8):1677-83.

15.

Biological activities of human tumor necrosis factor-alpha and its novel mutants.

Xi T, Shi X, Guo D, Dong X, Xu X, Zhu D.

Biochem Mol Biol Int. 1996 May;38(6):1183-9.

PMID:
8739040
16.

Human tumor necrosis factor alpha (TNF alpha) mutants with exclusive specificity for the 55-kDa or 75-kDa TNF receptors.

Loetscher H, Stueber D, Banner D, Mackay F, Lesslauer W.

J Biol Chem. 1993 Dec 15;268(35):26350-7.

17.

A mutated human tumor necrosis factor-alpha improves the therapeutic index in vitro and in vivo.

Yan Z, Zhao N, Wang Z, Li B, Bao C, Shi J, Han W, Zhang Y.

Cytotherapy. 2006;8(4):415-23.

PMID:
16923618
18.

Generation of a mouse tumor necrosis factor mutant with antiperitonitis and desensitization activities comparable to those of the wild type but with reduced systemic toxicity.

Lucas R, Echtenacher B, Sablon E, Juillard P, Magez S, Lou J, Donati Y, Bosman F, Van de Voorde A, Fransen L, Männel DN, Grau GE, de Baetselier P.

Infect Immun. 1997 Jun;65(6):2006-10.

19.
20.

Model complexes of tumor necrosis factor-alpha with receptors R1 and R2.

Fu ZQ, Harrison RW, Reed C, Wu J, Xue YN, Chen MJ, Weber IT.

Protein Eng. 1995 Dec;8(12):1233-41.

PMID:
8869635
Items per page

Supplemental Content

Support Center