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Items: 1 to 20 of 324

1.

3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro.

Alessi DR, Kozlowski MT, Weng QP, Morrice N, Avruch J.

Curr Biol. 1998 Jan 15;8(2):69-81.

2.

Evidence that 3-phosphoinositide-dependent protein kinase-1 mediates phosphorylation of p70 S6 kinase in vivo at Thr-412 as well as Thr-252.

Balendran A, Currie R, Armstrong CG, Avruch J, Alessi DR.

J Biol Chem. 1999 Dec 24;274(52):37400-6.

3.

Ribosomal S6 kinase 1 (RSK1) activation requires signals dependent on and independent of the MAP kinase ERK.

Richards SA, Fu J, Romanelli A, Shimamura A, Blenis J.

Curr Biol. 1999 Jul 29-Aug 12;9(15):810-20.

4.

The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells.

Williams MR, Arthur JS, Balendran A, van der Kaay J, Poli V, Cohen P, Alessi DR.

Curr Biol. 2000 Apr 20;10(8):439-48.

5.

Phosphorylation and activation of p70s6k by PDK1.

Pullen N, Dennis PB, Andjelkovic M, Dufner A, Kozma SC, Hemmings BA, Thomas G.

Science. 1998 Jan 30;279(5351):707-10.

6.
7.

90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1.

Jensen CJ, Buch MB, Krag TO, Hemmings BA, Gammeltoft S, Frödin M.

J Biol Chem. 1999 Sep 17;274(38):27168-76.

8.

Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro.

Isotani S, Hara K, Tokunaga C, Inoue H, Avruch J, Yonezawa K.

J Biol Chem. 1999 Nov 26;274(48):34493-8.

9.

Distinct regulatory mechanism for p70 S6 kinase beta from that for p70 S6 kinase alpha.

Minami T, Hara K, Oshiro N, Ueoku S, Yoshino K, Tokunaga C, Shirai Y, Saito N, Gout I, Yonezawa K.

Genes Cells. 2001 Nov;6(11):1003-15.

10.

Differential activation of protein kinase B and p70(S6)K by glucose and insulin-like growth factor 1 in pancreatic beta-cells (INS-1).

Dickson LM, Lingohr MK, McCuaig J, Hugl SR, Snow L, Kahn BB, Myers MG Jr, Rhodes CJ.

J Biol Chem. 2001 Jun 15;276(24):21110-20. Epub 2001 Mar 27.

11.

An array of insulin-activated, proline-directed serine/threonine protein kinases phosphorylate the p70 S6 kinase.

Mukhopadhyay NK, Price DJ, Kyriakis JM, Pelech S, Sanghera J, Avruch J.

J Biol Chem. 1992 Feb 15;267(5):3325-35.

13.

A minimal cytoplasmic subdomain of the erythropoietin receptor mediates p70 S6 kinase phosphorylation.

Zhang MY, Barber DL, Alessi DR, Bell LL, Stine C, Nguyen MH, Beattie BK, Cheung JY, Miller BA.

Exp Hematol. 2001 Apr;29(4):432-40.

PMID:
11301183
14.

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase.

Alessi DR, Deak M, Casamayor A, Caudwell FB, Morrice N, Norman DG, Gaffney P, Reese CB, MacDougall CN, Harbison D, Ashworth A, Bownes M.

Curr Biol. 1997 Oct 1;7(10):776-89.

15.

Identification of tyrosine phosphorylation sites on 3-phosphoinositide-dependent protein kinase-1 and their role in regulating kinase activity.

Park J, Hill MM, Hess D, Brazil DP, Hofsteenge J, Hemmings BA.

J Biol Chem. 2001 Oct 5;276(40):37459-71. Epub 2001 Jul 31.

17.
18.

In vivo role of the phosphate groove of PDK1 defined by knockin mutation.

Collins BJ, Deak M, Murray-Tait V, Storey KG, Alessi DR.

J Cell Sci. 2005 Nov 1;118(Pt 21):5023-34. Epub 2005 Oct 11.

19.

Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation site.

Saitoh M, Pullen N, Brennan P, Cantrell D, Dennis PB, Thomas G.

J Biol Chem. 2002 May 31;277(22):20104-12. Epub 2002 Mar 25.

20.

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