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A DNA double-strand break defective fibroblast cell line (180BR) derived from a radiosensitive patient represents a new mutant phenotype.

Badie C, Goodhardt M, Waugh A, Doyen N, Foray N, Calsou P, Singleton B, Gell D, Salles B, Jeggo P, Arlett CF, Malaise EP.

Cancer Res. 1997 Oct 15;57(20):4600-7.


The radiosensitive cell line 180BR is not defective in the major DNA damage-sensing proteins.

Lu H, Song Q, Arlett C, Lavin MF.

Cancer Res. 1998 Jan 1;58(1):84-8.


A new X-ray sensitive CHO cell mutant of ionizing radiation group 7,XR-C2, that is defective in DSB repair but has only a mild defect in V(D)J recombination.

Errami A, Overkamp WJ, He DM, Friedl AA, Gell DA, Eckardt-Schupp F, Jackson SP, Hendrickson EA, Lohman PH, Zdzienicka MZ.

Mutat Res. 2000 Sep 15;461(1):59-69.


Regulation of ATM in DNA double strand break repair accounts for the radiosensitivity in human cells exposed to high linear energy transfer ionizing radiation.

Xue L, Yu D, Furusawa Y, Okayasu R, Tong J, Cao J, Fan S.

Mutat Res. 2009 Nov 2;670(1-2):15-23. doi: 10.1016/j.mrfmmm.2009.06.016. Epub 2009 Jul 5.


Genetic evidence for the involvement of DNA ligase IV in the DNA-PK-dependent pathway of non-homologous end joining in mammalian cells.

Wang H, Zeng ZC, Perrault AR, Cheng X, Qin W, Iliakis G.

Nucleic Acids Res. 2001 Apr 15;29(8):1653-60.


Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient.

Riballo E, Critchlow SE, Teo SH, Doherty AJ, Priestley A, Broughton B, Kysela B, Beamish H, Plowman N, Arlett CF, Lehmann AR, Jackson SP, Jeggo PA.

Curr Biol. 1999 Jul 1;9(13):699-702.


Restoration of T cell-specific V(D)J recombination in DNA-PKcs(-/-) mice by ionizing radiation: The effects on survival, development, and tumorigenesis.

Li XL, Shen SR, Wang S, Ouyang HH, Li GC.

Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 2002 Mar;34(2):149-57.


Defective repair of DNA double-strand breaks and chromosome damage in fibroblasts from a radiosensitive leukemia patient.

Badie C, Iliakis G, Foray N, Alsbeih G, Pantellias GE, Okayasu R, Cheong N, Russell NS, Begg AC, Arlett CF, et al.

Cancer Res. 1995 Mar 15;55(6):1232-4.


The scid factor on human chromosome 8 restores V(D)J recombination in addition to double-strand break repair.

Komatsu K, Kubota N, Gallo M, Okumura Y, Lieber MR.

Cancer Res. 1995 Apr 15;55(8):1774-9.


Induction and rejoining of DNA double-strand breaks and interphase chromosome breaks after exposure to X rays in one normal and two hypersensitive human fibroblast cell lines.

Badie C, Iliakis G, Foray N, Alsbeih G, Cedervall B, Chavaudra N, Pantelias G, Arlett C, Malaise EP.

Radiat Res. 1995 Oct;144(1):26-35.


Expression of the DNA-PK binding protein E4-34K fails to confer radiation sensitivity to mammalian cells.

Collis SJ, Ketner GW, Hicks JL, Nelson WG, Demarzo AM, Deweese TL.

Int J Radiat Biol. 2003 Jan;79(1):53-60.


An ionizing radiation-sensitive CHO mutant cell line: irs-20. IV. Genetic complementation, V(D)J recombination and the scid phenotype.

Lin JY, Mühlmann-Diaz MC, Stackhouse MA, Robinson JF, Taccioli GE, Chen DJ, Bedford JS.

Radiat Res. 1997 Feb;147(2):166-71.


Menage à trois: double strand break repair, V(D)J recombination and DNA-PK.

Jeggo PA, Taccioli GE, Jackson SP.

Bioessays. 1995 Nov;17(11):949-57. Review.


Molecular and biochemical characterisation of DNA-dependent protein kinase-defective rodent mutant irs-20.

Priestley A, Beamish HJ, Gell D, Amatucci AG, Muhlmann-Diaz MC, Singleton BK, Smith GC, Blunt T, Schalkwyk LC, Bedford JS, Jackson SP, Jeggo PA, Taccioli GE.

Nucleic Acids Res. 1998 Apr 15;26(8):1965-73.


Roles of DNA-dependent protein kinase and ATM in cell-cycle-dependent radiation sensitivity in human cells.

Yoshida M, Hosoi Y, Miyachi H, Ishii N, Matsumoto Y, Enomoto A, Nakagawa K, Yamada S, Suzuki N, Ono T.

Int J Radiat Biol. 2002 Jun;78(6):503-12.


DNA-PK phosphorylation sites in XRCC4 are not required for survival after radiation or for V(D)J recombination.

Yu Y, Wang W, Ding Q, Ye R, Chen D, Merkle D, Schriemer D, Meek K, Lees-Miller SP.

DNA Repair (Amst). 2003 Nov 21;2(11):1239-52.


An anti-sense construct of full-length ATM cDNA imposes a radiosensitive phenotype on normal cells.

Zhang N, Chen P, Gatei M, Scott S, Khanna KK, Lavin MF.

Oncogene. 1998 Aug 20;17(7):811-8.


Radioresistant MTp53-expressing rat embryo cell transformants exhibit increased DNA-dsb rejoining during exposure to ionizing radiation.

Bristow RG, Hu Q, Jang A, Chung S, Peacock J, Benchimol S, Hill R.

Oncogene. 1998 Apr 9;16(14):1789-802.


ATM: the protein encoded by the gene mutated in the radiosensitive syndrome ataxia-telangiectasia.

Lavin MF, Khanna KK.

Int J Radiat Biol. 1999 Oct;75(10):1201-14. Review.


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