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TbetaRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling.

Abdollah S, Macías-Silva M, Tsukazaki T, Hayashi H, Attisano L, Wrana JL.

J Biol Chem. 1997 Oct 31;272(44):27678-85.


Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-beta signaling.

Souchelnytskyi S, Tamaki K, Engström U, Wernstedt C, ten Dijke P, Heldin CH.

J Biol Chem. 1997 Oct 31;272(44):28107-15.


TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4.

Nakao A, Imamura T, Souchelnytskyi S, Kawabata M, Ishisaki A, Oeda E, Tamaki K, Hanai J, Heldin CH, Miyazono K, ten Dijke P.

EMBO J. 1997 Sep 1;16(17):5353-62.


The transcriptional co-activator P/CAF potentiates TGF-beta/Smad signaling.

Itoh S, Ericsson J, Nishikawa J, Heldin CH, ten Dijke P.

Nucleic Acids Res. 2000 Nov 1;28(21):4291-8.


Inactivation of smad-transforming growth factor beta signaling by Ca(2+)-calmodulin-dependent protein kinase II.

Wicks SJ, Lui S, Abdel-Wahab N, Mason RM, Chantry A.

Mol Cell Biol. 2000 Nov;20(21):8103-11.


The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase.

Kretzschmar M, Liu F, Hata A, Doody J, Massagué J.

Genes Dev. 1997 Apr 15;11(8):984-95.


Semisynthesis of phosphovariants of Smad2 reveals a substrate preference of the activated T beta RI kinase.

Ottesen JJ, Huse M, Sekedat MD, Muir TW.

Biochemistry. 2004 May 18;43(19):5698-706.


Internalization-dependent and -independent requirements for transforming growth factor beta receptor signaling via the Smad pathway.

Penheiter SG, Mitchell H, Garamszegi N, Edens M, Doré JJ Jr, Leof EB.

Mol Cell Biol. 2002 Jul;22(13):4750-9.


Transforming growth factor-beta induces formation of a dithiothreitol-resistant type I/Type II receptor complex in live cells.

Wells RG, Gilboa L, Sun Y, Liu X, Henis YI, Lodish HF.

J Biol Chem. 1999 Feb 26;274(9):5716-22.


Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes.

Liu F, Pouponnot C, Massagué J.

Genes Dev. 1997 Dec 1;11(23):3157-67.


Targeting endogenous transforming growth factor beta receptor signaling in SMAD4-deficient human pancreatic carcinoma cells inhibits their invasive phenotype1.

Subramanian G, Schwarz RE, Higgins L, McEnroe G, Chakravarty S, Dugar S, Reiss M.

Cancer Res. 2004 Aug 1;64(15):5200-11.


Transforming growth factor-β signalling: role and consequences of Smad linker region phosphorylation.

Kamato D, Burch ML, Piva TJ, Rezaei HB, Rostam MA, Xu S, Zheng W, Little PJ, Osman N.

Cell Signal. 2013 Oct;25(10):2017-24. doi: 10.1016/j.cellsig.2013.06.001. Epub 2013 Jun 11. Review.


Microtubule binding to Smads may regulate TGF beta activity.

Dong C, Li Z, Alvarez R Jr, Feng XH, Goldschmidt-Clermont PJ.

Mol Cell. 2000 Jan;5(1):27-34.


Structural basis of Smad2 recognition by the Smad anchor for receptor activation.

Wu G, Chen YG, Ozdamar B, Gyuricza CA, Chong PA, Wrana JL, Massagué J, Shi Y.

Science. 2000 Jan 7;287(5450):92-7.


SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor.

Tsukazaki T, Chiang TA, Davison AF, Attisano L, Wrana JL.

Cell. 1998 Dec 11;95(6):779-91.

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