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Lhx2, a LIM homeobox gene, is required for eye, forebrain, and definitive erythrocyte development.

Porter FD, Drago J, Xu Y, Cheema SS, Wassif C, Huang SP, Lee E, Grinberg A, Massalas JS, Bodine D, Alt F, Westphal H.

Development. 1997 Aug;124(15):2935-44.


The LIM homeobox transcription factor Lhx2 is required to specify the retina field and synergistically cooperates with Pax6 for Six6 trans-activation.

Tétreault N, Champagne MP, Bernier G.

Dev Biol. 2009 Mar 15;327(2):541-50. doi: 10.1016/j.ydbio.2008.12.022. Epub 2008 Dec 30.


LHX2 is necessary for the maintenance of optic identity and for the progression of optic morphogenesis.

Roy A, de Melo J, Chaturvedi D, Thein T, Cabrera-Socorro A, Houart C, Meyer G, Blackshaw S, Tole S.

J Neurosci. 2013 Apr 17;33(16):6877-84. doi: 10.1523/JNEUROSCI.4216-12.2013.


Lhx2 links the intrinsic and extrinsic factors that control optic cup formation.

Yun S, Saijoh Y, Hirokawa KE, Kopinke D, Murtaugh LC, Monuki ES, Levine EM.

Development. 2009 Dec;136(23):3895-906. doi: 10.1242/dev.041202.


Reprogramming fibroblasts to neural-precursor-like cells by structured overexpression of pallial patterning genes.

Raciti M, Granzotto M, Duc MD, Fimiani C, Cellot G, Cherubini E, Mallamaci A.

Mol Cell Neurosci. 2013 Nov;57:42-53. doi: 10.1016/j.mcn.2013.10.004. Epub 2013 Oct 12.


Lhx2 is required for patterning and expansion of a distinct progenitor cell population committed to eye development.

Hägglund AC, Dahl L, Carlsson L.

PLoS One. 2011;6(8):e23387. doi: 10.1371/journal.pone.0023387. Epub 2011 Aug 19.


Isolation and characterization of a downstream target of Pax6 in the mammalian retinal primordium.

Bernier G, Vukovich W, Neidhardt L, Herrmann BG, Gruss P.

Development. 2001 Oct;128(20):3987-94.


Lhx2 regulates a cortex-specific mechanism for barrel formation.

Shetty AS, Godbole G, Maheshwari U, Padmanabhan H, Chaudhary R, Muralidharan B, Hou PS, Monuki ES, Kuo HC, Rema V, Tole S.

Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):E4913-21. doi: 10.1073/pnas.1311158110. Epub 2013 Nov 21.


LIM-homeodomain gene Lhx2 regulates the formation of the cortical hem.

Bulchand S, Grove EA, Porter FD, Tole S.

Mech Dev. 2001 Feb;100(2):165-75.


A role for Pax6 in the normal development of dorsal thalamus and its cortical connections.

Pratt T, Vitalis T, Warren N, Edgar JM, Mason JO, Price DJ.

Development. 2000 Dec;127(23):5167-78.


LHX2 regulates the neural differentiation of human embryonic stem cells via transcriptional modulation of PAX6 and CER1.

Hou PS, Chuang CY, Kao CF, Chou SJ, Stone L, Ho HN, Chien CL, Kuo HC.

Nucleic Acids Res. 2013 Sep;41(16):7753-70. doi: 10.1093/nar/gkt567. Epub 2013 Jun 26.


Function of Rx, but not Pax6, is essential for the formation of retinal progenitor cells in mice.

Zhang L, Mathers PH, Jamrich M.

Genesis. 2000 Nov-Dec;28(3-4):135-42.


Vax1, a novel homeobox-containing gene, directs development of the basal forebrain and visual system.

Hallonet M, Hollemann T, Pieler T, Gruss P.

Genes Dev. 1999 Dec 1;13(23):3106-14.


Midline signalling is required for Pax gene regulation and patterning of the eyes.

Macdonald R, Barth KA, Xu Q, Holder N, Mikkola I, Wilson SW.

Development. 1995 Oct;121(10):3267-78.


Mouse transgenesis identifies conserved functional enhancers and cis-regulatory motif in the vertebrate LIM homeobox gene Lhx2 locus.

Lee AP, Brenner S, Venkatesh B.

PLoS One. 2011;6(5):e20088. doi: 10.1371/journal.pone.0020088. Epub 2011 May 23.


Regulation of eye formation by the Rx and pax6 homeobox genes.

Mathers PH, Jamrich M.

Cell Mol Life Sci. 2000 Feb;57(2):186-94. Review.


Pax-6 is involved in the specification of hindbrain motor neuron subtype.

Osumi N, Hirota A, Ohuchi H, Nakafuku M, Iimura T, Kuratani S, Fujiwara M, Noji S, Eto K.

Development. 1997 Aug;124(15):2961-72.

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