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Items: 1 to 20 of 123

1.

Inactivation of Streptococcus pyogenes extracellular cysteine protease significantly decreases mouse lethality of serotype M3 and M49 strains.

Lukomski S, Sreevatsan S, Amberg C, Reichardt W, Woischnik M, Podbielski A, Musser JM.

J Clin Invest. 1997 Jun 1;99(11):2574-80.

2.

Genetic inactivation of an extracellular cysteine protease (SpeB) expressed by Streptococcus pyogenes decreases resistance to phagocytosis and dissemination to organs.

Lukomski S, Burns EH Jr, Wyde PR, Podbielski A, Rurangirwa J, Moore-Poveda DK, Musser JM.

Infect Immun. 1998 Feb;66(2):771-6.

3.

Inactivation of the cysteine protease SpeB affects hyaluronic acid capsule expression in group A streptococci.

Woischnik M, Buttaro BA, Podbielski A.

Microb Pathog. 2000 Apr;28(4):221-6.

PMID:
10764613
5.

Role of streptococcal pyrogenic exotoxin B in the mouse model of group A streptococcal infection.

Kuo CF, Wu JJ, Lin KY, Tsai PJ, Lee SC, Jin YT, Lei HY, Lin YS.

Infect Immun. 1998 Aug;66(8):3931-5.

6.

A conserved Streptococcus pyogenes extracellular cysteine protease cleaves human fibronectin and degrades vitronectin.

Kapur V, Topouzis S, Majesky MW, Li LL, Hamrick MR, Hamill RJ, Patti JM, Musser JM.

Microb Pathog. 1993 Nov;15(5):327-46.

PMID:
7516997
8.

Group A streptococcal cysteine protease cleaves epithelial junctions and contributes to bacterial translocation.

Sumitomo T, Nakata M, Higashino M, Terao Y, Kawabata S.

J Biol Chem. 2013 May 10;288(19):13317-24. doi: 10.1074/jbc.M113.459875. Epub 2013 Mar 26.

9.

Extracellular cysteine protease produced by Streptococcus pyogenes participates in the pathogenesis of invasive skin infection and dissemination in mice.

Lukomski S, Montgomery CA, Rurangirwa J, Geske RS, Barrish JP, Adams GJ, Musser JM.

Infect Immun. 1999 Apr;67(4):1779-88.

10.

A natural variant of the cysteine protease virulence factor of group A Streptococcus with an arginine-glycine-aspartic acid (RGD) motif preferentially binds human integrins alphavbeta3 and alphaIIbbeta3.

Stockbauer KE, Magoun L, Liu M, Burns EH Jr, Gubba S, Renish S, Pan X, Bodary SC, Baker E, Coburn J, Leong JM, Musser JM.

Proc Natl Acad Sci U S A. 1999 Jan 5;96(1):242-7.

11.

Effect of group A streptococcal cysteine protease on invasion of epithelial cells.

Tsai PJ, Kuo CF, Lin KY, Lin YS, Lei HY, Chen FF, Wang JR, Wu JJ.

Infect Immun. 1998 Apr;66(4):1460-6.

12.

Role of group A Streptococcus HtrA in the maturation of SpeB protease.

Cole JN, Aquilina JA, Hains PG, Henningham A, Sriprakash KS, Caparon MG, Nizet V, Kotb M, Cordwell SJ, Djordjevic SP, Walker MJ.

Proteomics. 2007 Dec;7(24):4488-98.

PMID:
18072207
14.

Crystal structure of the zymogen form of the group A Streptococcus virulence factor SpeB: an integrin-binding cysteine protease.

Kagawa TF, Cooney JC, Baker HM, McSweeney S, Liu M, Gubba S, Musser JM, Baker EN.

Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2235-40.

15.

The majority of 9,729 group A streptococcus strains causing disease secrete SpeB cysteine protease: pathogenesis implications.

Olsen RJ, Raghuram A, Cantu C, Hartman MH, Jimenez FE, Lee S, Ngo A, Rice KA, Saddington D, Spillman H, Valson C, Flores AR, Beres SB, Long SW, Nasser W, Musser JM.

Infect Immun. 2015 Dec;83(12):4750-8. doi: 10.1128/IAI.00989-15. Epub 2015 Sep 28.

16.

An amino-terminal signal peptide of Vfr protein negatively influences RopB-dependent SpeB expression and attenuates virulence in Streptococcus pyogenes.

Shelburne SA 3rd, Olsen RJ, Makthal N, Brown NG, Sahasrabhojane P, Watkins EM, Palzkill T, Musser JM, Kumaraswami M.

Mol Microbiol. 2011 Dec;82(6):1481-95. doi: 10.1111/j.1365-2958.2011.07902.x. Epub 2011 Nov 21.

17.

Invasive M1T1 group A Streptococcus undergoes a phase-shift in vivo to prevent proteolytic degradation of multiple virulence factors by SpeB.

Aziz RK, Pabst MJ, Jeng A, Kansal R, Low DE, Nizet V, Kotb M.

Mol Microbiol. 2004 Jan;51(1):123-34.

18.
19.

Dispersal of Group A streptococcal biofilms by the cysteine protease SpeB leads to increased disease severity in a murine model.

Connolly KL, Roberts AL, Holder RC, Reid SD.

PLoS One. 2011 Apr 25;6(4):e18984. doi: 10.1371/journal.pone.0018984.

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