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Cloning and characterization of AFX, the gene that fuses to MLL in acute leukemias with a t(X;11)(q13;q23).

Borkhardt A, Repp R, Haas OA, Leis T, Harbott J, Kreuder J, Hammermann J, Henn T, Lampert F.

Oncogene. 1997 Jan 16;14(2):195-202.


Acute leukemias of different lineages have similar MLL gene fusions encoding related chimeric proteins resulting from chromosomal translocation.

Corral J, Forster A, Thompson S, Lampert F, Kaneko Y, Slater R, Kroes WG, van der Schoot CE, Ludwig WD, Karpas A, et al.

Proc Natl Acad Sci U S A. 1993 Sep 15;90(18):8538-42.


DNA rearrangements and altered transcripts of the MLL gene in a human T-ALL cell line Karpas 45 with a t(X;11) (q13;q23) translocation.

McCabe NR, Kipiniak M, Kobayashi H, Thirman M, Gill H, Rowley JD, Diaz MO.

Genes Chromosomes Cancer. 1994 Mar;9(3):221-4.


Characterization of genomic breakpoints in MLL and CBP in leukemia patients with t(11;16).

Zhang Y, Zeleznik-Le N, Emmanuel N, Jayathilaka N, Chen J, Strissel P, Strick R, Li L, Neilly MB, Taki T, Hayashi Y, Kaneko Y, Schlegelberger B, Rowley JD.

Genes Chromosomes Cancer. 2004 Nov;41(3):257-65.


Identification of complex genomic breakpoint junctions in the t(9;11) MLL-AF9 fusion gene in acute leukemia.

Super HG, Strissel PL, Sobulo OM, Burian D, Reshmi SC, Roe B, Zeleznik-Le NJ, Diaz MO, Rowley JD.

Genes Chromosomes Cancer. 1997 Oct;20(2):185-95.


MLL and CALM are fused to AF10 in morphologically distinct subsets of acute leukemia with translocation t(10;11): both rearrangements are associated with a poor prognosis.

Dreyling MH, Schrader K, Fonatsch C, Schlegelberger B, Haase D, Schoch C, Ludwig W, Löffler H, Büchner T, Wörmann B, Hiddemann W, Bohlander SK.

Blood. 1998 Jun 15;91(12):4662-7.


AF6q21, a novel partner of the MLL gene in t(6;11)(q21;q23), defines a forkhead transcriptional factor subfamily.

Hillion J, Le Coniat M, Jonveaux P, Berger R, Bernard OA.

Blood. 1997 Nov 1;90(9):3714-9.


AF15q14, a novel partner gene fused to the MLL gene in an acute myeloid leukaemia with a t(11;15)(q23;q14).

Hayette S, Tigaud I, Vanier A, Martel S, Corbo L, Charrin C, Beillard E, Deleage G, Magaud JP, Rimokh R.

Oncogene. 2000 Sep 7;19(38):4446-50.


Analysis of t(9;11) chromosomal breakpoint sequences in childhood acute leukemia: almost identical MLL breakpoints in therapy-related AML after treatment without etoposides.

Langer T, Metzler M, Reinhardt D, Viehmann S, Borkhardt A, Reichel M, Stanulla M, Schrappe M, Creutzig U, Ritter J, Leis T, Jacobs U, Harbott J, Beck JD, Rascher W, Repp R.

Genes Chromosomes Cancer. 2003 Apr;36(4):393-401.


The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene.

Gu Y, Nakamura T, Alder H, Prasad R, Canaani O, Cimino G, Croce CM, Canaani E.

Cell. 1992 Nov 13;71(4):701-8.


Characterization of the MLL partner gene AF15q14 involved in t(11;15)(q23;q14).

Kuefer MU, Chinwalla V, Zeleznik-Le NJ, Behm FG, Naeve CW, Rakestraw KM, Mukatira ST, Raimondi SC, Morris SW.

Oncogene. 2003 Mar 6;22(9):1418-24.


Human LPP gene is fused to MLL in a secondary acute leukemia with a t(3;11) (q28;q23).

Dahéron L, Veinstein A, Brizard F, Drabkin H, Lacotte L, Guilhot F, Larsen CJ, Brizard A, Roche J.

Genes Chromosomes Cancer. 2001 Aug;31(4):382-9.


Translocation (8;12)(q13;p13) during disease progression in acute myelomonocytic leukemia with t(11;19)(q23;p13.1).

Yamamoto K, Nagata K, Tsurukubo Y, Inagaki K, Ono R, Taki T, Hayashi Y, Hamaguchi H.

Cancer Genet Cytogenet. 2002 Aug;137(1):64-7.


A novel chromosomal inversion at 11q23 in infant acute myeloid leukemia fuses MLL to CALM, a gene that encodes a clathrin assembly protein.

Wechsler DS, Engstrom LD, Alexander BM, Motto DG, Roulston D.

Genes Chromosomes Cancer. 2003 Jan;36(1):26-36.


A serine/proline-rich protein is fused to HRX in t(4;11) acute leukemias.

Morrissey J, Tkachuk DC, Milatovich A, Francke U, Link M, Cleary ML.

Blood. 1993 Mar 1;81(5):1124-31.


The MYO1F, unconventional myosin type 1F, gene is fused to MLL in infant acute monocytic leukemia with a complex translocation involving chromosomes 7, 11, 19 and 22.

Taki T, Akiyama M, Saito S, Ono R, Taniwaki M, Kato Y, Yuza Y, Eto Y, Hayashi Y.

Oncogene. 2005 Aug 4;24(33):5191-7.


Analysis of the t(6;11)(q27;q23) in leukemia shows a consistent breakpoint in AF6 in three patients and in the ML-2 cell line.

Tanabe S, Zeleznik-Le NJ, Kobayashi H, Vignon C, Espinosa R 3rd, LeBeau MM, Thirman MJ, Rowley JD.

Genes Chromosomes Cancer. 1996 Apr;15(4):206-16.


Molecular analysis of t(11;19) breakpoints in childhood acute leukemias.

Rubnitz JE, Behm FG, Curcio-Brint AM, Pinheiro RP, Carroll AJ, Raimondi SC, Shurtleff SA, Downing JR.

Blood. 1996 Jun 1;87(11):4804-8.

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