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Dual roles for patched in sequestering and transducing Hedgehog.

Chen Y, Struhl G.

Cell. 1996 Nov 1;87(3):553-63.


Patched represses the Hedgehog signalling pathway by promoting modification of the Smoothened protein.

Ingham PW, Nystedt S, Nakano Y, Brown W, Stark D, van den Heuvel M, Taylor AM.

Curr Biol. 2000 Oct 19;10(20):1315-8.


Mutations in the sterol-sensing domain of Patched suggest a role for vesicular trafficking in Smoothened regulation.

Strutt H, Thomas C, Nakano Y, Stark D, Neave B, Taylor AM, Ingham PW.

Curr Biol. 2001 Apr 17;11(8):608-13. Erratum in: Curr Biol 2001 Jul 24;11(14):1153.


Ihog and Boi elicit Hh signaling via Ptc but do not aid Ptc in sequestering the Hh ligand.

Camp D, Haitian He B, Li S, Althaus IW, Holtz AM, Allen BL, Charron F, van Meyel DJ.

Development. 2014 Oct;141(20):3879-88. doi: 10.1242/dev.103564. Epub 2014 Sep 17.


Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction.

Zhu AJ, Zheng L, Suyama K, Scott MP.

Genes Dev. 2003 May 15;17(10):1240-52. Epub 2003 May 2.


Reading the Hedgehog morphogen gradient by measuring the ratio of bound to unbound Patched protein.

Casali A, Struhl G.

Nature. 2004 Sep 2;431(7004):76-80. Epub 2004 Aug 8.


Functional domains and sub-cellular distribution of the Hedgehog transducing protein Smoothened in Drosophila.

Nakano Y, Nystedt S, Shivdasani AA, Strutt H, Thomas C, Ingham PW.

Mech Dev. 2004 Jun;121(6):507-18.


Sonic hedgehog signaling by the patched-smoothened receptor complex.

Murone M, Rosenthal A, de Sauvage FJ.

Curr Biol. 1999 Jan 28;9(2):76-84.


G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling.

Ogden SK, Fei DL, Schilling NS, Ahmed YF, Hwa J, Robbins DJ.

Nature. 2008 Dec 18;456(7224):967-70. doi: 10.1038/nature07459.


Smoothened oligomerization/higher order clustering in lipid rafts is essential for high Hedgehog activity transduction.

Shi D, Lv X, Zhang Z, Yang X, Zhou Z, Zhang L, Zhao Y.

J Biol Chem. 2013 May 3;288(18):12605-14. doi: 10.1074/jbc.M112.399477. Epub 2013 Mar 26.


Regulation of smoothened by Drosophila G-protein-coupled receptor kinases.

Cheng S, Maier D, Neubueser D, Hipfner DR.

Dev Biol. 2010 Jan 1;337(1):99-109. doi: 10.1016/j.ydbio.2009.10.014. Epub 2009 Oct 20.


Activation of Smurf E3 ligase promoted by smoothened regulates hedgehog signaling through targeting patched turnover.

Huang S, Zhang Z, Zhang C, Lv X, Zheng X, Chen Z, Sun L, Wang H, Zhu Y, Zhang J, Yang S, Lu Y, Sun Q, Tao Y, Liu F, Zhao Y, Chen D.

PLoS Biol. 2013 Nov;11(11):e1001721. doi: 10.1371/journal.pbio.1001721. Epub 2013 Nov 26.

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