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The embAB genes of Mycobacterium avium encode an arabinosyl transferase involved in cell wall arabinan biosynthesis that is the target for the antimycobacterial drug ethambutol.

Belanger AE, Besra GS, Ford ME, Mikusová K, Belisle JT, Brennan PJ, Inamine JM.

Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11919-24.


A single point mutation in the embB gene is responsible for resistance to ethambutol in Mycobacterium smegmatis.

Lety MA, Nair S, Berche P, Escuyer V.

Antimicrob Agents Chemother. 1997 Dec;41(12):2629-33.


The emb operon, a gene cluster of Mycobacterium tuberculosis involved in resistance to ethambutol.

Telenti A, Philipp WJ, Sreevatsan S, Bernasconi C, Stockbauer KE, Wieles B, Musser JM, Jacobs WR Jr.

Nat Med. 1997 May;3(5):567-70.


Mutations in the embC-embA intergenic region contribute to Mycobacterium tuberculosis resistance to ethambutol.

Cui Z, Li Y, Cheng S, Yang H, Lu J, Hu Z, Ge B.

Antimicrob Agents Chemother. 2014 Nov;58(11):6837-43. doi: 10.1128/AAC.03285-14. Epub 2014 Sep 2.


The arabinosyltransferase EmbC is inhibited by ethambutol in Mycobacterium tuberculosis.

Goude R, Amin AG, Chatterjee D, Parish T.

Antimicrob Agents Chemother. 2009 Oct;53(10):4138-46. doi: 10.1128/AAC.00162-09. Epub 2009 Jul 13.


Ethambutol resistance in Mycobacterium tuberculosis: critical role of embB mutations.

Sreevatsan S, Stockbauer KE, Pan X, Kreiswirth BN, Moghazeh SL, Jacobs WR Jr, Telenti A, Musser JM.

Antimicrob Agents Chemother. 1997 Aug;41(8):1677-81.


The role of the embA and embB gene products in the biosynthesis of the terminal hexaarabinofuranosyl motif of Mycobacterium smegmatis arabinogalactan.

Escuyer VE, Lety MA, Torrelles JB, Khoo KH, Tang JB, Rithner CD, Frehel C, McNeil MR, Brennan PJ, Chatterjee D.

J Biol Chem. 2001 Dec 28;276(52):48854-62. Epub 2001 Oct 24.


Transfer of the first arabinofuranose residue to galactan is essential for Mycobacterium smegmatis viability.

Shi L, Zhou R, Liu Z, Lowary TL, Seeberger PH, Stocker BL, Crick DC, Khoo KH, Chatterjee D.

J Bacteriol. 2008 Aug;190(15):5248-55. doi: 10.1128/JB.00028-08. Epub 2008 Jun 13.


Mutations Found in embCAB, embR, and ubiA Genes of Ethambutol-Sensitive and -Resistant Mycobacterium tuberculosis Clinical Isolates from China.

Xu Y, Jia H, Huang H, Sun Z, Zhang Z.

Biomed Res Int. 2015;2015:951706. doi: 10.1155/2015/951706. Epub 2015 Aug 31.


Deletion of Cg-emb in corynebacterianeae leads to a novel truncated cell wall arabinogalactan, whereas inactivation of Cg-ubiA results in an arabinan-deficient mutant with a cell wall galactan core.

Alderwick LJ, Radmacher E, Seidel M, Gande R, Hitchen PG, Morris HR, Dell A, Sahm H, Eggeling L, Besra GS.

J Biol Chem. 2005 Sep 16;280(37):32362-71. Epub 2005 Jul 21.


Biogenesis of the mycobacterial cell wall and the site of action of ethambutol.

Mikusová K, Slayden RA, Besra GS, Brennan PJ.

Antimicrob Agents Chemother. 1995 Nov;39(11):2484-9.


emb nucleotide polymorphisms and the role of embB306 mutations in Mycobacterium tuberculosis resistance to ethambutol.

Srivastava S, Ayyagari A, Dhole TN, Nyati KK, Dwivedi SK.

Int J Med Microbiol. 2009 Apr;299(4):269-80. doi: 10.1016/j.ijmm.2008.07.001. Epub 2008 Nov 17.


Role of embB in natural and acquired resistance to ethambutol in mycobacteria.

Alcaide F, Pfyffer GE, Telenti A.

Antimicrob Agents Chemother. 1997 Oct;41(10):2270-3.


Truncated structural variants of lipoarabinomannan in ethambutol drug-resistant strains of Mycobacterium smegmatis. Inhibition of arabinan biosynthesis by ethambutol.

Khoo KH, Douglas E, Azadi P, Inamine JM, Besra GS, Mikusová K, Brennan PJ, Chatterjee D.

J Biol Chem. 1996 Nov 8;271(45):28682-90.


Genetic characterisation of the ethambutol resistance-determining region in Mycobacterium tuberculosis: prevalence and significance of embB306 mutations.

Perdigão J, Macedo R, Ribeiro A, Brum L, Portugal I.

Int J Antimicrob Agents. 2009 Apr;33(4):334-8. doi: 10.1016/j.ijantimicag.2008.09.021. Epub 2008 Dec 18.


ubiA (Rv3806c) encoding DPPR synthase involved in cell wall synthesis is associated with ethambutol resistance in Mycobacterium tuberculosis.

He L, Wang X, Cui P, Jin J, Chen J, Zhang W, Zhang Y.

Tuberculosis (Edinb). 2015 Mar;95(2):149-54. doi: 10.1016/ Epub 2014 Dec 13.


Ethambutol, a cell wall inhibitor of Mycobacterium tuberculosis, elicits L-glutamate efflux of Corynebacterium glutamicum.

Radmacher E, Stansen KC, Besra GS, Alderwick LJ, Maughan WN, Hollweg G, Sahm H, Wendisch VF, Eggeling L.

Microbiology. 2005 May;151(Pt 5):1359-68.


Mutations in the embB locus among Korean clinical isolates of Mycobacterium tuberculosis resistant to ethambutol.

Lee HY, Myoung HJ, Bang HE, Bai GH, Kim SJ, Kim JD, Cho SN.

Yonsei Med J. 2002 Feb;43(1):59-64. Erratum in: Yonsei Med J 2002 Aug;43(4):557.

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