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Items: 1 to 20 of 84

1.

Conformational change and enhanced stabilization of the vitamin D receptor by the 1,25-dihydroxyvitamin D3 analog KH1060.

van den Bemd GC, Pols HA, Birkenhäger JC, van Leeuwen JP.

Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10685-90.

2.

Contribution of several metabolites of the vitamin D analog 20-epi-22-oxa-24a,26a,27a-tri-homo-1,25-(OH)(2) vitamin D(3) (KH 1060) to the overall biological activity of KH1060 by a shared mechanism of action.

van den Bemd GC, Dilworth FJ, Makin HL, Prahl JM, Deluca HF, Jones G, Pols HA, van Leeuwen JP.

Biochem Pharmacol. 2000 Mar 15;59(6):621-7.

PMID:
10677578
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Differential effects of 1,25-dihydroxyvitamin D3-analogs on osteoblast-like cells and on in vitro bone resorption.

van den Bemd GJ, Pols HA, Birkenhäger JC, Kleinekoort WM, van Leeuwen JP.

J Steroid Biochem Mol Biol. 1995 Dec;55(3-4):337-46.

PMID:
8541230
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The vitamin D analog, KH1060, is rapidly degraded both in vivo and in vitro via several pathways: principal metabolites generated retain significant biological activity.

Dilworth FJ, Williams GR, Kissmeyer AM, Nielsen JL, Binderup E, Calverley MJ, Makin HL, Jones G.

Endocrinology. 1997 Dec;138(12):5485-96.

PMID:
9389535
9.

Interaction of two novel 14-epivitamin D3 analogs with vitamin D3 receptor-retinoid X receptor heterodimers on vitamin D3 responsive elements.

Verlinden L, Verstuyf A, Quack M, Van Camp M, Van Etten E, De Clercq P, Vandewalle M, Carlberg C, Bouillon R.

J Bone Miner Res. 2001 Apr;16(4):625-38.

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Response element and coactivator-mediated conformational change of the vitamin D(3) receptor permits sensitive interaction with agonists.

Herdick M, Bury Y, Quack M, Uskokovic MR, Polly P, Carlberg C.

Mol Pharmacol. 2000 Jun;57(6):1206-17.

12.

Modulation of vitamin D receptor and estrogen receptor by 1,25(OH)2-vitamin D3 in T-47D human breast cancer cells.

Davoodi F, Brenner RV, Evans SR, Schumaker LM, Shabahang M, Nauta RJ, Buras RR.

J Steroid Biochem Mol Biol. 1995 Aug;54(3-4):147-53.

PMID:
7662588
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2-Methylene-19-nor-(20S)-1,25-dihydroxyvitamin D3 potently stimulates gene-specific DNA binding of the vitamin D receptor in osteoblasts.

Yamamoto H, Shevde NK, Warrier A, Plum LA, DeLuca HF, Pike JW.

J Biol Chem. 2003 Aug 22;278(34):31756-65.

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Analysis of vitamin D analog-induced heterodimerization of vitamin D receptor with retinoid X receptor using the yeast two-hybrid system.

Zhao XY, Eccleshall TR, Krishnan AV, Gross C, Feldman D.

Mol Endocrinol. 1997 Mar;11(3):366-78.

PMID:
9058382
19.

A central dinucleotide within vitamin D response elements modulates DNA binding and transactivation by the vitamin D receptor in cellular response to natural and synthetic ligands.

van den Bemd GJ, Jhamai M, Staal A, van Wijnen AJ, Lian JB, Stein GS, Pols HA, van Leeuwen JP.

J Biol Chem. 2002 Apr 26;277(17):14539-46.

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