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Items: 1 to 20 of 117


Mammalian NUMB is an evolutionarily conserved signaling adapter protein that specifies cell fate.

Verdi JM, Schmandt R, Bashirullah A, Jacob S, Salvino R, Craig CG, Program AE, Lipshitz HD, McGlade CJ.

Curr Biol. 1996 Sep 1;6(9):1134-45.


Functional analysis of the Numb phosphotyrosine-binding domain using site-directed mutagenesis.

Yaich L, Ooi J, Park M, Borg JP, Landry C, Bodmer R, Margolis B.

J Biol Chem. 1998 Apr 24;273(17):10381-8.


A novel transmembrane protein recruits numb to the plasma membrane during asymmetric cell division.

Qin H, Percival-Smith A, Li C, Jia CY, Gloor G, Li SS.

J Biol Chem. 2004 Mar 19;279(12):11304-12. Epub 2003 Dec 11.


Distinct functions of human numb isoforms revealed by misexpression in the neural stem cell lineage in the Drosophila larval brain.

Toriya M, Tokunaga A, Sawamoto K, Nakao K, Okano H.

Dev Neurosci. 2006;28(1-2):142-55.


Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis.

Zhong W, Jiang MM, Weinmaster G, Jan LY, Jan YN.

Development. 1997 May;124(10):1887-97.


Distinct human NUMB isoforms regulate differentiation vs. proliferation in the neuronal lineage.

Verdi JM, Bashirullah A, Goldhawk DE, Kubu CJ, Jamali M, Meakin SO, Lipshitz HD.

Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10472-6.


The Drosophila Numb protein inhibits signaling of the Notch receptor during cell-cell interaction in sensory organ lineage.

Frise E, Knoblich JA, Younger-Shepherd S, Jan LY, Jan YN.

Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11925-32.


Transgenic expression of numb inhibits notch signaling in immature thymocytes but does not alter T cell fate specification.

French MB, Koch U, Shaye RE, McGill MA, Dho SE, Guidos CJ, McGlade CJ.

J Immunol. 2002 Apr 1;168(7):3173-80.


Numb independently antagonizes Sanpodo membrane targeting and Notch signaling in Drosophila sensory organ precursor cells.

Tong X, Zitserman D, Serebriiskii I, Andrake M, Dunbrack R, Roegiers F.

Mol Biol Cell. 2010 Mar 1;21(5):802-10. doi: 10.1091/mbc.E09-09-0831. Epub 2010 Jan 6.


The endocytic protein alpha-Adaptin is required for numb-mediated asymmetric cell division in Drosophila.

Berdnik D, Török T, González-Gaitán M, Knoblich JA.

Dev Cell. 2002 Aug;3(2):221-31.


High-affinity binding of the Drosophila Numb phosphotyrosine-binding domain to peptides containing a Gly-Pro-(p)Tyr motif.

Li SC, Songyang Z, Vincent SJ, Zwahlen C, Wiley S, Cantley L, Kay LE, Forman-Kay J, Pawson T.

Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7204-9.


Structure of a Numb PTB domain-peptide complex suggests a basis for diverse binding specificity.

Li SC, Zwahlen C, Vincent SJ, McGlade CJ, Kay LE, Pawson T, Forman-Kay JD.

Nat Struct Biol. 1998 Dec;5(12):1075-83.


Zebrafish Numb homologue: phylogenetic evolution and involvement in regulation of left-right asymmetry.

Niikura Y, Tabata Y, Tajima A, Inoue I, Arai K, Watanabe S.

Mech Dev. 2006 May;123(5):407-14. Epub 2006 May 15.


A mouse homologue of Drosophila pins can asymmetrically localize and substitute for pins function in Drosophila neuroblasts.

Yu F, Morin X, Kaushik R, Bahri S, Yang X, Chia W.

J Cell Sci. 2003 Mar 1;116(Pt 5):887-96.

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