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A polygenic mouse model of psoriasiform skin disease in CD18-deficient mice.

Bullard DC, Scharffetter-Kochanek K, McArthur MJ, Chosay JG, McBride ME, Montgomery CA, Beaudet AL.

Proc Natl Acad Sci U S A. 1996 Mar 5;93(5):2116-21.


CD4+ T cell-associated pathophysiology critically depends on CD18 gene dose effects in a murine model of psoriasis.

Kess D, Peters T, Zamek J, Wickenhauser C, Tawadros S, Loser K, Varga G, Grabbe S, Nischt R, Sunderkötter C, Müller W, Krieg T, Scharffetter-Kochanek K.

J Immunol. 2003 Dec 1;171(11):5697-706.


Identification of susceptibility loci for skin disease in a murine psoriasis model.

Kess D, Lindqvist AK, Peters T, Wang H, Zamek J, Nischt R, Broman KW, Blakytny R, Krieg T, Holmdahl R, Scharffetter-Kochanek K.

J Immunol. 2006 Oct 1;177(7):4612-9.


A 9-centimorgan interval of chromosome 10 controls the T cell-dependent psoriasiform skin disease and arthritis in a murine psoriasis model.

Wang H, Kess D, Lindqvist AK, Peters T, Sindrilaru A, Wlaschek M, Blakytny R, Holmdahl R, Scharffetter-Kochanek K.

J Immunol. 2008 Apr 15;180(8):5520-9.


Development of dermatitis in CD18-deficient PL/J mice is not dependent on bacterial flora, and requires both CD4+ and CD8+ T lymphocytes.

Barlow SC, Xu H, Weaver CT, Lindsey JR, Schoeb TR, Bullard DC.

Int Immunol. 2004 Feb;16(2):345-51.


Reduction of CD18 promotes expansion of inflammatory γδ T cells collaborating with CD4+ T cells in chronic murine psoriasiform dermatitis.

Gatzka M, Hainzl A, Peters T, Singh K, Tasdogan A, Wlaschek M, Scharffetter-Kochanek K.

J Immunol. 2013 Dec 1;191(11):5477-88. doi: 10.4049/jimmunol.1300976. Epub 2013 Nov 4.


JAK3 inhibition significantly attenuates psoriasiform skin inflammation in CD18 mutant PL/J mice.

Chang BY, Zhao F, He X, Ren H, Braselmann S, Taylor V, Wicks J, Payan DG, Grossbard EB, Pine PR, Bullard DC.

J Immunol. 2009 Aug 1;183(3):2183-92. doi: 10.4049/jimmunol.0804063. Epub 2009 Jul 13.


Targeting NF-kappa B with a natural triterpenoid alleviates skin inflammation in a mouse model of psoriasis.

Wang H, Syrovets T, Kess D, Büchele B, Hainzl H, Lunov O, Weiss JM, Scharffetter-Kochanek K, Simmet T.

J Immunol. 2009 Oct 1;183(7):4755-63. doi: 10.4049/jimmunol.0900521. Epub 2009 Sep 14.


IL-12, independently of IFN-gamma, plays a crucial role in the pathogenesis of a murine psoriasis-like skin disorder.

Hong K, Chu A, Lúdvíksson BR, Berg EL, Ehrhardt RO.

J Immunol. 1999 Jun 15;162(12):7480-91.


Gene targeting yields a CD18-mutant mouse for study of inflammation.

Wilson RW, Ballantyne CM, Smith CW, Montgomery C, Bradley A, O'Brien WE, Beaudet AL.

J Immunol. 1993 Aug 1;151(3):1571-8.


Cutaneous inflammatory disorder in integrin alphaE (CD103)-deficient mice.

Schön MP, Schön M, Warren HB, Donohue JP, Parker CM.

J Immunol. 2000 Dec 1;165(11):6583-9.


Activated macrophages are essential in a murine model for T cell-mediated chronic psoriasiform skin inflammation.

Wang H, Peters T, Kess D, Sindrilaru A, Oreshkova T, Van Rooijen N, Stratis A, Renkl AC, Sunderkötter C, Wlaschek M, Haase I, Scharffetter-Kochanek K.

J Clin Invest. 2006 Aug;116(8):2105-14.


TGF-beta-dependent suppressive function of Tregs requires wild-type levels of CD18 in a mouse model of psoriasis.

Wang H, Peters T, Sindrilaru A, Kess D, Oreshkova T, Yu XZ, Seier AM, Schreiber H, Wlaschek M, Blakytny R, Röhrbein J, Schulz G, Weiss JM, Scharffetter-Kochanek K.

J Clin Invest. 2008 Jul;118(7):2629-39. doi: 10.1172/JCI34916.


Key role of macrophages in the pathogenesis of CD18 hypomorphic murine model of psoriasis.

Wang H, Peters T, Sindrilaru A, Scharffetter-Kochanek K.

J Invest Dermatol. 2009 May;129(5):1100-14. doi: 10.1038/jid.2009.43. Epub 2009 Feb 26. Review.


Neutrophil emigration in the skin, lungs, and peritoneum: different requirements for CD11/CD18 revealed by CD18-deficient mice.

Mizgerd JP, Kubo H, Kutkoski GJ, Bhagwan SD, Scharffetter-Kochanek K, Beaudet AL, Doerschuk CM.

J Exp Med. 1997 Oct 20;186(8):1357-64.


Impairment of neutrophil emigration in CD18-null mice.

Walzog B, Scharffetter-Kochanek K, Gaehtgens P.

Am J Physiol. 1999 May;276(5 Pt 1):G1125-30.


Development and progression of psoriasiform dermatitis and systemic lesions in the flaky skin (fsn) mouse mutant.

Sundberg JP, France M, Boggess D, Sundberg BA, Jenson AB, Beamer WG, Shultz LD.

Pathobiology. 1997;65(5):271-86.


[Psoriasis SCID-mouse model].

Pfeffer J, Kaufmann R, Boehncke WH.

Hautarzt. 2006 Jul;57(7):603-9. Review. German.


A spontaneous mutation characterized by chronic proliferative dermatitis in C57BL mice.

HogenEsch H, Gijbels MJ, Offerman E, van Hooft J, van Bekkum DW, Zurcher C.

Am J Pathol. 1993 Sep;143(3):972-82.

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