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The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A.

Orth K, Chinnaiyan AM, Garg M, Froelich CJ, Dixit VM.

J Biol Chem. 1996 Jul 12;271(28):16443-6.


Cytotoxic T-cell-derived granzyme B activates the apoptotic protease ICE-LAP3.

Chinnaiyan AM, Hanna WL, Orth K, Duan H, Poirier GG, Froelich CJ, Dixit VM.

Curr Biol. 1996 Jul 1;6(7):897-9.


ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B.

Duan H, Orth K, Chinnaiyan AM, Poirier GG, Froelich CJ, He WW, Dixit VM.

J Biol Chem. 1996 Jul 12;271(28):16720-4.


The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32.

Srinivasula SM, Fernandes-Alnemri T, Zangrilli J, Robertson N, Armstrong RC, Wang L, Trapani JA, Tomaselli KJ, Litwack G, Alnemri ES.

J Biol Chem. 1996 Oct 25;271(43):27099-106.


Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family.

Fernandes-Alnemri T, Litwack G, Alnemri ES.

Cancer Res. 1995 Jul 1;55(13):2737-42.


Fas-induced activation of the cell death-related protease CPP32 Is inhibited by Bcl-2 and by ICE family protease inhibitors.

Armstrong RC, Aja T, Xiang J, Gaur S, Krebs JF, Hoang K, Bai X, Korsmeyer SJ, Karanewsky DS, Fritz LC, Tomaselli KJ.

J Biol Chem. 1996 Jul 12;271(28):16850-5.


Bcl-2 expression in neural cells blocks activation of ICE/CED-3 family proteases during apoptosis.

Srinivasan A, Foster LM, Testa MP, Ord T, Keane RW, Bredesen DE, Kayalar C.

J Neurosci. 1996 Sep 15;16(18):5654-60.


Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase.

Tewari M, Quan LT, O'Rourke K, Desnoyers S, Zeng Z, Beidler DR, Poirier GG, Salvesen GS, Dixit VM.

Cell. 1995 Jun 2;81(5):801-9.


The apoptotic cysteine protease CPP32.

Kumar S.

Int J Biochem Cell Biol. 1997 Mar;29(3):393-6. Review.


Mch3, a novel human apoptotic cysteine protease highly related to CPP32.

Fernandes-Alnemri T, Takahashi A, Armstrong R, Krebs J, Fritz L, Tomaselli KJ, Wang L, Yu Z, Croce CM, Salveson G, et al.

Cancer Res. 1995 Dec 15;55(24):6045-52.


Molecular ordering of the cell death pathway. Bcl-2 and Bcl-xL function upstream of the CED-3-like apoptotic proteases.

Chinnaiyan AM, Orth K, O'Rourke K, Duan H, Poirier GG, Dixit VM.

J Biol Chem. 1996 Mar 1;271(9):4573-6.


Processing of the Nedd2 precursor by ICE-like proteases and granzyme B.

Harvey NL, Trapani JA, Fernandes-Alnemri T, Litwack G, Alnemri ES, Kumar S.

Genes Cells. 1996 Jul;1(7):673-85.


Baculovirus P35 inhibits the glucocorticoid-mediated pathway of cell death.

Robertson NM, Zangrilli J, Fernandes-Alnemri T, Friesen PD, Litwack G, Alnemri ES.

Cancer Res. 1997 Jan 1;57(1):43-7.


Proteolytic activation of the cell death protease Yama/CPP32 by granzyme B.

Quan LT, Tewari M, O'Rourke K, Dixit V, Snipas SJ, Poirier GG, Ray C, Pickup DJ, Salvesen GS.

Proc Natl Acad Sci U S A. 1996 Mar 5;93(5):1972-6.


Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis.

Takahashi A, Alnemri ES, Lazebnik YA, Fernandes-Alnemri T, Litwack G, Moir RD, Goldman RD, Poirier GG, Kaufmann SH, Earnshaw WC.

Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8395-400.


Role of Ced-3/ICE-family proteases in staurosporine-induced programmed cell death.

Jacobsen MD, Weil M, Raff MC.

J Cell Biol. 1996 Jun;133(5):1041-51.


Bcl-xL overexpression inhibits taxol-induced Yama protease activity and apoptosis.

Ibrado AM, Huang Y, Fang G, Bhalla K.

Cell Growth Differ. 1996 Aug;7(8):1087-94.

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