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Items: 1 to 20 of 101

1.

Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells.

Schulz VP, Zakian VA, Ogburn CE, McKay J, Jarzebowicz AA, Edland SD, Martin GM.

Hum Genet. 1996 Jun;97(6):750-4.

PMID:
8641691
2.

Accelerated in vivo epidermal telomere loss in Werner syndrome.

Ishikawa N, Nakamura K, Izumiyama-Shimomura N, Aida J, Ishii A, Goto M, Ishikawa Y, Asaka R, Matsuura M, Hatamochi A, Kuroiwa M, Takubo K.

Aging (Albany NY). 2011 Apr;3(4):417-29.

3.

Normal telomere erosion rates at the single cell level in Werner syndrome fibroblast cells.

Baird DM, Davis T, Rowson J, Jones CJ, Kipling D.

Hum Mol Genet. 2004 Jul 15;13(14):1515-24. Epub 2004 May 18.

PMID:
15150162
4.
5.
6.

WRN controls formation of extrachromosomal telomeric circles and is required for TRF2DeltaB-mediated telomere shortening.

Li B, Jog SP, Reddy S, Comai L.

Mol Cell Biol. 2008 Mar;28(6):1892-904. doi: 10.1128/MCB.01364-07. Epub 2008 Jan 22.

7.

Reprogramming suppresses premature senescence phenotypes of Werner syndrome cells and maintains chromosomal stability over long-term culture.

Shimamoto A, Kagawa H, Zensho K, Sera Y, Kazuki Y, Osaki M, Oshimura M, Ishigaki Y, Hamasaki K, Kodama Y, Yuasa S, Fukuda K, Hirashima K, Seimiya H, Koyama H, Shimizu T, Takemoto M, Yokote K, Goto M, Tahara H.

PLoS One. 2014 Nov 12;9(11):e112900. doi: 10.1371/journal.pone.0112900. eCollection 2014.

8.

Werner syndrome protein suppresses the formation of large deletions during the replication of human telomeric sequences.

Damerla RR, Knickelbein KE, Strutt S, Liu FJ, Wang H, Opresko PL.

Cell Cycle. 2012 Aug 15;11(16):3036-44. doi: 10.4161/cc.21399. Epub 2012 Aug 8.

9.

Diverse gene sequences are overexpressed in werner syndrome fibroblasts undergoing premature replicative senescence.

Murano S, Thweatt R, Shmookler Reis RJ, Jones RA, Moerman EJ, Goldstein S.

Mol Cell Biol. 1991 Aug;11(8):3905-14.

10.

Increased chromosome instability and accumulation of DNA double-strand breaks in Werner syndrome cells.

Ariyoshi K, Suzuki K, Goto M, Watanabe M, Kodama S.

J Radiat Res. 2007 May;48(3):219-31. Epub 2007 Apr 23.

11.

Prevention of accelerated cell aging in the Werner syndrome.

Davis T, Haughton MF, Jones CJ, Kipling D.

Ann N Y Acad Sci. 2006 May;1067:243-7. Review.

PMID:
16803993
12.

The gene responsible for Werner syndrome may be a cell division "counting" gene.

Faragher RG, Kill IR, Hunter JA, Pope FM, Tannock C, Shall S.

Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):12030-4.

13.

Abnormal fibroblast aging and DNA replication in the Werner syndrome.

Fujiwara Y, Kano Y, Ichihashi M, Nakao Y, Matsumura T.

Adv Exp Med Biol. 1985;190:459-77.

PMID:
4083160
14.

Spectral karyotyping of Werner syndrome fibroblast cultures.

Melcher R, von Golitschek R, Steinlein C, Schindler D, Neitzel H, Kainer K, Schmid M, Hoehn H.

Cytogenet Cell Genet. 2000;91(1-4):180-5.

PMID:
11173853
15.

Telomere-based proliferative lifespan barriers in Werner-syndrome fibroblasts involve both p53-dependent and p53-independent mechanisms.

Davis T, Singhrao SK, Wyllie FS, Haughton MF, Smith PJ, Wiltshire M, Wynford-Thomas D, Jones CJ, Faragher RG, Kipling D.

J Cell Sci. 2003 Apr 1;116(Pt 7):1349-57.

16.

Mutator phenotype of Werner syndrome is characterized by extensive deletions.

Fukuchi K, Martin GM, Monnat RJ Jr.

Proc Natl Acad Sci U S A. 1989 Aug;86(15):5893-7. Erratum in: Proc Natl Acad Sci U S A 1989 Oct;86(20):7994.

17.

Telomere dysfunction as a cause of genomic instability in Werner syndrome.

Crabbe L, Jauch A, Naeger CM, Holtgreve-Grez H, Karlseder J.

Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2205-10. Epub 2007 Feb 6.

18.

The role of cellular senescence in Werner syndrome: toward therapeutic intervention in human premature aging.

Davis T, Wyllie FS, Rokicki MJ, Bagley MC, Kipling D.

Ann N Y Acad Sci. 2007 Apr;1100:455-69. Review.

PMID:
17460211
19.
20.

A model for the phenotypic presentation of Werner's syndrome.

Ostler EL, Wallis CV, Sheerin AN, Faragher RG.

Exp Gerontol. 2002 Jan-Mar;37(2-3):285-92. Review.

PMID:
11772514

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