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8610363,8610364,11787527,10573075,8779687,8864436,12012046,1585475,8884109,1972728,9212108,1387333,16183077,16858289,8816385,11145725,11726819,2562984,8027542,10447745,22948444,1828637,11207246,14734723,11737848,16082333,21920556,7906567,10392959,7499847,9852899,26177088,10430609,10642595,9808477,15021823,9679828,12384443,10910938,22228418,21242693,12433677,7522366,23250336,10861032,14678032,10459540,11302548,7594573,9288126,20719075,19524257,12099378,16041269,7871570,17046021,7570945,2137269,12865813,8522358,10905768,10609955,15548965,7839449,10861026,11301194,8560550,9583862,26337731,14508367,8456484,8762020,15939670,11571439,15588949,19920776,21697774,2039833,14512313,9728927,17876108,27306533,12727476,20950686,21176787,22484382,7491703,12084998,11435961,27872868,12099638,18314139,12463477,15856178,18580473,20061915,10798737,10589955,15385800,9116307,12352905,9500619,19604303,17485279,11435318,12842706,10360586,18714669,8893455,12463476,18280792,12576326,10609947,10852594,25783859,14962909,17241922,22550390,1467526,1465774,17286617,9625763,12543110,9108408,30728353,11045634,11602846,10910268,12919088,15374883,25394378,2569241,17283484,16638128,1465769,11154237,15268726,8560547,10920206,15888027,23223359,9311707,28766890,7833486,14738294,9175799,12490786,11374414,27846155,3501157,29300231,20072086,8958273,12182461,23694950,12200389,8420037,26209354,15494429,24339700,11455249,18768896,8541562,6121405,22929594,12451240,8824489,8115352,12182463,10961297,18853957,9000673,7582911,15848518,10933165,31754236,2653469,12791660,7521742,7908768,2675227,20871628,10706892,15498851,9921809,22728248,12451248,19249572,12130490,11014644,23580663,10798770,9808589,12070042,2141885,10798769,32442182,8843586,8560549,8279020,26576864,3076379,6346607,11579288,7704543,12134094,32633070,31634324,2224135,12544867,23240587,11579314,15846286,19380803,24468120,21304439,1991176,10459536,15591948,11045644,25220786,20954841,17564635,10833246,15316366,21270266,19027614,29699851,10836379,10480416,9256191,12814472,11939602,24304495,18751946,2238052,16314778,9123268,8902396,12694546,8453111,22082819,7903344,12177612,7638733,9039935,15591949,9915258,2886228,21726515,18778285,20536788,21791423,11493477,12368032,10517491,9848220,26495767,11740386,21562444,27500470,9618519,21831158,12430849,9197364,21220748,2014544,11477369,32002911,8279017,12070043,10480403,8456465,9039923,12368037,8279022,6349042,10556210,32185855,18408584,10708124,11112055,12609833,15077020,36351397,22974315,2646775,8212171,24804993,9352379,32732835,1531395,11349715,7482720,11986242,14739221,11571465,7770920,11877303,9204989,9603171,26917238,3883586,23994246,30113996,10852616,3907045,8610423,15940036,9865283,8295567,16314799,9123270,26731275,15307826,16741251,3299924,15928035,8094580,19134161,1358260,11520813,26190648,12931117,1359684,10191971,3318032,7570987,21666482,22174155,14611905,9290774,9484743,15585939,30346652,19273089,23567123,11271280,12131681,19100524,18828766,26200095,8830829,9885237,8781619,20148810,11889448,21364417,10798744,20042725,8333035,1349332,11215693,16371922,3291987,22509425,1347961,12384412,21085064,16796719,8751585,1680254,9311703,18675355,1531393,32271163,33775618,33730087,9116281,10836380,17353791,10910267,17369487,8097343,16258305,3912318,373075,11685116,2150169,24165326,8669111,14726386,15201677,1967216,7015617,3520991,23623394,10828052,33570785,7492799,9123588,8400273,9256196,10868630,22805476,19328921,23656242,15880048,8212161,16888094,25155089,6990564,11342461,10836388,23834725,19955659,20605588,20452826,7839434,34633538,22642491,8977258,8610404,11750635,12234171,65036,8456460,3313836,12433683,1758170,18347343,11233894,22281302,3103273,8420048,10755518,8100092,23651511,2573181,20041865,9233712,16954501,33186221,35619720,12394849,19539209,10546153,8461477,33127498,8073518,9197347,6204774,26273682,23328386,11729252,17294522,15912100,30801529,2861675,3513395,22053723,14550811,23894468,33812438,12036893,2186521,9123202,11266770,9848224,8970615,36101964,10688849,9596648,12714515,16340737,24472193,3512457,11152096,34681764,3513396,32075272,35235568,11435983,19104426,26602894,11345089,241143,6350170,2890226,8972556,8970617,9500608,14592817,29289741,20380282,29046484,8098231,11685103,10836381,8101401,19965631,11271319,9368771,29630967,9713173,23869083,2256160,22952774,16302994,2031261,7489407,9479877,20714863,10385077,31996467,9547344,8610418,15753840,2890295,11787529,1987708,24106398,7485121,12180819,10077628,9123281,35222384,25311657,11389040,2875752,21705229,11105259,18334670,12740217,1091043,6195712,7551985,11120069,36932237,19179478,19011222,14629282,19812489,16291598,11595570,6444769,2655223,3311201,15585938,8540010,28713424,22134165,2301005,7974727,8887065,8154031,35995393,2321009,9723527,12869956,10515898,19459808,15604221,11418484,22074621,12034273,3289152,22509427,22566869,24869940,8932256,6373619,22085453,21659540,14663279,2804367,23703256,7804525,11266751,8898747,1343102,12438975,10836360,26082829,1702726,32511714,10342074,21653831,341488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Additional monoclonal antibody (mAB) injections can replace thymic irradiation to allow induction of mixed chimerism and tolerance in mice receiving bone marrow transplantation after conditioning with anti-T cell mABs and 3-Gy whole body irradiation.

Tomita Y, Sachs DH, Khan A, Sykes M. Tomita Y, et al. Transplantation. 1996 Feb 15;61(3):469-77. doi: 10.1097/00007890-199602150-00027. Transplantation. 1996. PMID: 8610363

Mechanism by which additional monoclonal antibody (mAB) injections overcome the requirement for thymic irradiation to achieve mixed chimerism in mice receiving bone marrow transplantation after conditioning with anti-T cell mABs and 3-Gy whole body irradiation.

Tomita Y, Khan A, Sykes M. Tomita Y, et al. Transplantation. 1996 Feb 15;61(3):477-85. doi: 10.1097/00007890-199602150-00028. Transplantation. 1996. PMID: 8610364

Induction of stable long-term mixed hematopoietic chimerism following nonmyeloablative conditioning with T cell-depleting antibodies, cyclophosphamide, and thymic irradiation leads to donor-specific in vitro and in vivo tolerance.

Mapara MY, Pelot M, Zhao G, Swenson K, Pearson D, Sykes M. Mapara MY, et al. Biol Blood Marrow Transplant. 2001;7(12):646-55. doi: 10.1053/bbmt.2001.v7.pm11787527. Biol Blood Marrow Transplant. 2001. PMID: 11787527 Free article.

Anti-CD154 or CTLA4Ig obviates the need for thymic irradiation in a non-myeloablative conditioning regimen for the induction of mixed hematopoietic chimerism and tolerance.

Wekerle T, Sayegh MH, Ito H, Hill J, Chandraker A, Pearson DA, Swenson KG, Zhao G, Sykes M. Wekerle T, et al. Transplantation. 1999 Nov 15;68(9):1348-55. doi: 10.1097/00007890-199911150-00022. Transplantation. 1999. PMID: 10573075

Thymic dependence of loss of tolerance in mixed allogeneic bone marrow chimeras after depletion of donor antigen. Peripheral mechanisms do not contribute to maintenance of tolerance.

Khan A, Tomita Y, Sykes M. Khan A, et al. Transplantation. 1996 Aug 15;62(3):380-7. doi: 10.1097/00007890-199608150-00014. Transplantation. 1996. PMID: 8779687

Alloresistance to K locus class I-mismatched bone marrow engraftment is mediated entirely by CD4+ and CD8+ T cells.

Hayashi H, LeGuern C, Sachs DH, Sykes M. Hayashi H, et al. Bone Marrow Transplant. 1996 Aug;18(2):285-92. Bone Marrow Transplant. 1996. PMID: 8864436

Minimal conditioning required in a murine model of T cell depletion, thymic irradiation and high-dose bone marrow transplantation for the induction of mixed chimerism and tolerance.

Wekerle T, Nikolic B, Pearson DA, Swenson KG, Sykes M. Wekerle T, et al. Transpl Int. 2002 May;15(5):248-53. doi: 10.1007/s00147-002-0411-3. Epub 2002 Apr 11. Transpl Int. 2002. PMID: 12012046

Humoral tolerance in xenogeneic BMT recipients conditioned by a nonmyeloablative regimen.

Aksentijevich I, Sachs DH, Sykes M. Aksentijevich I, et al. Transplantation. 1992 May;53(5):1108-14. doi: 10.1097/00007890-199205000-00025. Transplantation. 1992. PMID: 1585475

Hematopoietic cell transplantation for the induction of allo- and xenotolerance.

Sykes M. Sykes M. Clin Transplant. 1996 Aug;10(4):357-63. Clin Transplant. 1996. PMID: 8884109 Review.

Specific tolerance induction across a xenogeneic barrier: production of mixed rat/mouse lymphohematopoietic chimeras using a nonlethal preparative regimen.

Sharabi Y, Aksentijevich I, Sundt TM 3rd, Sachs DH, Sykes M. Sharabi Y, et al. J Exp Med. 1990 Jul 1;172(1):195-202. doi: 10.1084/jem.172.1.195. J Exp Med. 1990. PMID: 1972728 Free PMC article.

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