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Demonstration of a direct interaction between p56lck and the cytoplasmic domain of CD45 in vitro.

Ng DH, Watts JD, Aebersold R, Johnson P.

J Biol Chem. 1996 Jan 19;271(3):1295-300.


Subdomain X of the kinase domain of Lck binds CD45 and facilitates dephosphorylation.

Felberg J, Lefebvre DC, Lam M, Wang Y, Ng DH, Birkenhead D, Cross JL, Johnson P.

J Biol Chem. 2004 Jan 30;279(5):3455-62. Epub 2003 Nov 17.


The SH2 domain is required for stable phosphorylation of p56lck at tyrosine 505, the negative regulatory site.

Gervais FG, Chow LM, Lee JM, Branton PE, Veillette A.

Mol Cell Biol. 1993 Nov;13(11):7112-21.


The Src homology 2 domain of the protein-tyrosine kinase p56lck mediates both intermolecular and intramolecular interactions.

Amrein KE, Panholzer B, Flint NA, Bannwarth W, Burn P.

Proc Natl Acad Sci U S A. 1993 Nov 1;90(21):10285-9.


Modification of Ser59 in the unique N-terminal region of tyrosine kinase p56lck regulates specificity of its Src homology 2 domain.

Joung I, Kim T, Stolz LA, Payne G, Winkler DG, Walsh CT, Strominger JL, Shin J.

Proc Natl Acad Sci U S A. 1995 Jun 20;92(13):5778-82.


Association of CD45 with Lck and components of the Ras signalling pathway in pervanadate-treated mouse T-cell lines.

Lee JM, Fournel M, Veillette A, Branton PE.

Oncogene. 1996 Jan 18;12(2):253-63.


Stable interdomain interaction within the cytoplasmic domain of CD45 increases enzyme stability.

Felberg J, Johnson P.

Biochem Biophys Res Commun. 2000 May 10;271(2):292-8.


Tyrosine phosphorylation of CD45 phosphotyrosine phosphatase by p50csk kinase creates a binding site for p56lck tyrosine kinase and activates the phosphatase.

Autero M, Saharinen J, Pessa-Morikawa T, Soula-Rothhut M, Oetken C, Gassmann M, Bergman M, Alitalo K, Burn P, Gahmberg CG, et al.

Mol Cell Biol. 1994 Feb;14(2):1308-21.


Substrate conformational restriction and CD45-catalyzed dephosphorylation of tail tyrosine-phosphorylated Src protein.

Wang D, Esselman WJ, Cole PA.

J Biol Chem. 2002 Oct 25;277(43):40428-33. Epub 2002 Aug 13.


Binding affinities of the SH2 domains of ZAP-70, p56lck and Shc to the zeta chain ITAMs of the T-cell receptor determined by surface plasmon resonance.

Labadia ME, Ingraham RH, Schembri-King J, Morelock MM, Jakes S.

J Leukoc Biol. 1996 May;59(5):740-6.


The catalytic activity of the CD45 membrane-proximal phosphatase domain is required for TCR signaling and regulation.

Desai DM, Sap J, Silvennoinen O, Schlessinger J, Weiss A.

EMBO J. 1994 Sep 1;13(17):4002-10.


Detection of a physical and functional interaction between Csk and Lck which involves the SH2 domain of Csk and is mediated by autophosphorylation of Lck on tyrosine 394.

Bougeret C, Delaunay T, Romero F, Jullien P, Sabe H, Hanafusa H, Benarous R, Fischer S.

J Biol Chem. 1996 Mar 29;271(13):7465-72.


The SH3 domain of Src tyrosyl protein kinase interacts with the N-terminal splice region of the PDE4A cAMP-specific phosphodiesterase RPDE-6 (RNPDE4A5).

O'Connell JC, McCallum JF, McPhee I, Wakefield J, Houslay ES, Wishart W, Bolger G, Frame M, Houslay MD.

Biochem J. 1996 Aug 15;318 ( Pt 1):255-61.

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