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Items: 1 to 20 of 91

1.

Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase.

Powis G, Bonjouklian R, Berggren MM, Gallegos A, Abraham R, Ashendel C, Zalkow L, Matter WF, Dodge J, Grindey G, et al.

Cancer Res. 1994 May 1;54(9):2419-23.

2.

Studies on the mechanism of phosphatidylinositol 3-kinase inhibition by wortmannin and related analogs.

Norman BH, Shih C, Toth JE, Ray JE, Dodge JA, Johnson DW, Rutherford PG, Schultz RM, Worzalla JF, Vlahos CJ.

J Med Chem. 1996 Mar 1;39(5):1106-11.

PMID:
8676346
4.

Wortmannin, a specific phosphatidylinositol 3-kinase inhibitor, inhibits adipocytic differentiation of 3T3-L1 cells.

Tomiyama K, Nakata H, Sasa H, Arimura S, Nishio E, Watanabe Y.

Biochem Biophys Res Commun. 1995 Jul 6;212(1):263-9.

PMID:
7541986
6.

Wortmannin inhibits insulin secretion in pancreatic islets and beta-TC3 cells independent of its inhibition of phosphatidylinositol 3-kinase.

Gao Z, Konrad RJ, Collins H, Matschinsky FM, Rothenberg PL, Wolf BA.

Diabetes. 1996 Jul;45(7):854-62.

PMID:
8666133
7.

Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells.

Yano H, Nakanishi S, Kimura K, Hanai N, Saitoh Y, Fukui Y, Nonomura Y, Matsuda Y.

J Biol Chem. 1993 Dec 5;268(34):25846-56.

8.

Effects of wortmannin analogs on bone in vitro and in vivo.

Sato M, Bryant HU, Dodge JA, Davis H, Matter WF, Vlahos CJ.

J Pharmacol Exp Ther. 1996 Apr;277(1):543-50.

PMID:
8613966
12.

Effects of wortmannin on glucose uptake and protein kinase C activity in rat adipocytes.

Ishizuka T, Nagashima T, Yamamoto M, Kajita K, Yamada K, Wada H, Itaya S, Yasuda K, Nozawa Y.

Diabetes Res Clin Pract. 1995 Sep;29(3):143-52.

PMID:
8591706
13.

In vitro and in vivo antitumor activity of the phosphatidylinositol-3-kinase inhibitor, wortmannin.

Schultz RM, Merriman RL, Andis SL, Bonjouklian R, Grindey GB, Rutherford PG, Gallegos A, Massey K, Powis G.

Anticancer Res. 1995 Jul-Aug;15(4):1135-9.

PMID:
7653991
14.
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16.

Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction.

Wymann MP, Bulgarelli-Leva G, Zvelebil MJ, Pirola L, Vanhaesebroeck B, Waterfield MD, Panayotou G.

Mol Cell Biol. 1996 Apr;16(4):1722-33.

17.

Neurite outgrowth of PC12 cells is suppressed by wortmannin, a specific inhibitor of phosphatidylinositol 3-kinase.

Kimura K, Hattori S, Kabuyama Y, Shizawa Y, Takayanagi J, Nakamura S, Toki S, Matsuda Y, Onodera K, Fukui Y.

J Biol Chem. 1994 Jul 22;269(29):18961-7.

18.

Different pathways of inhibitory effects of wortmannin on exocytosis are revealed by video-enhanced light microscope.

Ozawa K, Masujima T, Ikeda K, Kodama Y, Nonomura Y.

Biochem Biophys Res Commun. 1996 May 15;222(2):243-8.

PMID:
8670190
19.

The phosphatidylinositol 3-kinase inhibitor wortmannin blocks mast cell exocytosis but not IL-6 production.

Marquardt DL, Alongi JL, Walker LL.

J Immunol. 1996 Mar 1;156(5):1942-5.

PMID:
8596048
20.

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