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Defective B cell development and function in Btk-deficient mice.

Khan WN, Alt FW, Gerstein RM, Malynn BA, Larsson I, Rathbun G, Davidson L, Müller S, Kantor AB, Herzenberg LA, et al.

Immunity. 1995 Sep;3(3):283-99.


Impaired expansion of mouse B cell progenitors lacking Btk.

Kerner JD, Appleby MW, Mohr RN, Chien S, Rawlings DJ, Maliszewski CR, Witte ON, Perlmutter RM.

Immunity. 1995 Sep;3(3):301-12.


An essential role for Bruton's [corrected] tyrosine kinase in the regulation of B-cell apoptosis.

Anderson JS, Teutsch M, Dong Z, Wortis HH.

Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10966-71. Erratum in: proc Natl Acad Sci U S A 1996 Dec 24;93(26):15522.


Complementary roles for CD19 and Bruton's tyrosine kinase in B lymphocyte signal transduction.

Fujimoto M, Poe JC, Satterthwaite AB, Wahl MI, Witte ON, Tedder TF.

J Immunol. 2002 Jun 1;168(11):5465-76.


Severe B cell deficiency in mice lacking the tec kinase family members Tec and Btk.

Ellmeier W, Jung S, Sunshine MJ, Hatam F, Xu Y, Baltimore D, Mano H, Littman DR.

J Exp Med. 2000 Dec 4;192(11):1611-24.


Regulation of nuclear localization and transcriptional activity of TFII-I by Bruton's tyrosine kinase.

Novina CD, Kumar S, Bajpai U, Cheriyath V, Zhang K, Pillai S, Wortis HH, Roy AL.

Mol Cell Biol. 1999 Jul;19(7):5014-24.


The X-linked immunodeficiency defect in the mouse is corrected by expression of human Bruton's tyrosine kinase from a yeast artificial chromosome transgene.

Maas A, Dingjan GM, Savelkoul HF, Kinnon C, Grosveld F, Hendriks RW.

Eur J Immunol. 1997 Sep;27(9):2180-7.


xid mice reveal the interplay of homeostasis and Bruton's tyrosine kinase-mediated selection at multiple stages of B cell development.

Cancro MP, Sah AP, Levy SL, Allman DM, Schmidt MR, Woodland RT.

Int Immunol. 2001 Dec;13(12):1501-14.


Correction of B-cell development in Btk-deficient mice using lentiviral vectors with codon-optimized human BTK.

Ng YY, Baert MR, Pike-Overzet K, Rodijk M, Brugman MH, Schambach A, Baum C, Hendriks RW, van Dongen JJ, Staal FJ.

Leukemia. 2010 Sep;24(9):1617-30. doi: 10.1038/leu.2010.140. Epub 2010 Jun 24.


Sustained correction of B-cell development and function in a murine model of X-linked agammaglobulinemia (XLA) using retroviral-mediated gene transfer.

Yu PW, Tabuchi RS, Kato RM, Astrakhan A, Humblet-Baron S, Kipp K, Chae K, Ellmeier W, Witte ON, Rawlings DJ.

Blood. 2004 Sep 1;104(5):1281-90. Epub 2004 May 13.


Posttranscriptional regulation of Bruton's tyrosine kinase expression in antigen receptor-stimulated splenic B cells.

Nisitani S, Satterthwaite AB, Akashi K, Weissman IL, Witte ON, Wahl MI.

Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2737-42. Erratum in: Proc Natl Acad Sci U S A 2000 May 9;97(10):5679.


Transcription factor STAT5A is a substrate of Bruton's tyrosine kinase in B cells.

Mahajan S, Vassilev A, Sun N, Ozer Z, Mao C, Uckun FM.

J Biol Chem. 2001 Aug 17;276(33):31216-28. Epub 2001 Jun 18.


Btk dosage determines sensitivity to B cell antigen receptor cross-linking.

Satterthwaite AB, Cheroutre H, Khan WN, Sideras P, Witte ON.

Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):13152-7.


Bruton's tyrosine kinase is not essential for LPS-induced activation of human monocytes.

Pérez de Diego R, López-Granados E, Pozo M, Rodríguez C, Sabina P, Ferreira A, Fontan G, García-Rodríguez MC, Alemany S.

J Allergy Clin Immunol. 2006 Jun;117(6):1462-9. Epub 2006 Mar 31.


Role of Bruton's tyrosine kinase in B cell development.

Maas A, Hendriks RW.

Dev Immunol. 2001;8(3-4):171-81. Review.


Impaired B cell maturation in mice lacking Bruton's tyrosine kinase (Btk) and CD40.

Khan WN, Nilsson A, Mizoguchi E, Castigli E, Forsell J, Bhan AK, Geha R, Sideras P, Alt FW.

Int Immunol. 1997 Mar;9(3):395-405.


B cell-specific lentiviral gene therapy leads to sustained B-cell functional recovery in a murine model of X-linked agammaglobulinemia.

Kerns HM, Ryu BY, Stirling BV, Sather BD, Astrakhan A, Humblet-Baron S, Liggitt D, Rawlings DJ.

Blood. 2010 Mar 18;115(11):2146-55. doi: 10.1182/blood-2009-09-241869. Epub 2010 Jan 21.


Severe B cell deficiency and disrupted splenic architecture in transgenic mice expressing the E41K mutated form of Bruton's tyrosine kinase.

Dingjan GM, Maas A, Nawijn MC, Smit L, Voerman JS, Grosveld F, Hendriks RW.

EMBO J. 1998 Sep 15;17(18):5309-20.

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