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TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40.

Rothe M, Sarma V, Dixit VM, Goeddel DV.

Science. 1995 Sep 8;269(5229):1424-7.


Differential requirements for tumor necrosis factor receptor-associated factor family proteins in CD40-mediated induction of NF-kappaB and Jun N-terminal kinase activation.

Leo E, Welsh K, Matsuzawa S, Zapata JM, Kitada S, Mitchell RS, Ely KR, Reed JC.

J Biol Chem. 1999 Aug 6;274(32):22414-22.


Tumor necrosis factor receptor-associated factor (TRAF) 1 regulates CD40-induced TRAF2-mediated NF-kappaB activation.

Fotin-Mleczek M, Henkler F, Hausser A, Glauner H, Samel D, Graness A, Scheurich P, Mauri D, Wajant H.

J Biol Chem. 2004 Jan 2;279(1):677-85. Epub 2003 Oct 13.


TNF receptor (TNFR)-associated factor (TRAF) 3 serves as an inhibitor of TRAF2/5-mediated activation of the noncanonical NF-kappaB pathway by TRAF-binding TNFRs.

Hauer J, PĆ¼schner S, Ramakrishnan P, Simon U, Bongers M, Federle C, Engelmann H.

Proc Natl Acad Sci U S A. 2005 Feb 22;102(8):2874-9. Epub 2005 Feb 11.


The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor.

Wong BR, Josien R, Lee SY, Vologodskaia M, Steinman RM, Choi Y.

J Biol Chem. 1998 Oct 23;273(43):28355-9.


High-affinity interactions of tumor necrosis factor receptor-associated factors (TRAFs) and CD40 require TRAF trimerization and CD40 multimerization.

Pullen SS, Labadia ME, Ingraham RH, McWhirter SM, Everdeen DS, Alber T, Crute JJ, Kehry MR.

Biochemistry. 1999 Aug 3;38(31):10168-77.


Epstein-Barr virus-encoded LMP1 and CD40 mediate IL-6 production in epithelial cells via an NF-kappaB pathway involving TNF receptor-associated factors.

Eliopoulos AG, Stack M, Dawson CW, Kaye KM, Hodgkin L, Sihota S, Rowe M, Young LS.

Oncogene. 1997 Jun 19;14(24):2899-916.


Tumor necrosis factor receptor-associated factor 2 (TRAF2)-deficient B lymphocytes reveal novel roles for TRAF2 in CD40 signaling.

Hostager BS, Haxhinasto SA, Rowland SL, Bishop GA.

J Biol Chem. 2003 Nov 14;278(46):45382-90. Epub 2003 Sep 4.


Tumor necrosis factor alpha-induced activation of c-jun N-terminal kinase is mediated by TRAF2.

Reinhard C, Shamoon B, Shyamala V, Williams LT.

EMBO J. 1997 Mar 3;16(5):1080-92.


Human 4-1BB (CD137) signals are mediated by TRAF2 and activate nuclear factor-kappa B.

Jang IK, Lee ZH, Kim YJ, Kim SH, Kwon BS.

Biochem Biophys Res Commun. 1998 Jan 26;242(3):613-20.


TRAF3 forms heterotrimers with TRAF2 and modulates its ability to mediate NF-{kappa}B activation.

He L, Grammer AC, Wu X, Lipsky PE.

J Biol Chem. 2004 Dec 31;279(53):55855-65. Epub 2004 Sep 21.


A novel RING finger protein interacts with the cytoplasmic domain of CD40.

Hu HM, O'Rourke K, Boguski MS, Dixit VM.

J Biol Chem. 1994 Dec 2;269(48):30069-72.


Cooperation between TNF receptor-associated factors 1 and 2 in CD40 signaling.

Xie P, Hostager BS, Munroe ME, Moore CR, Bishop GA.

J Immunol. 2006 May 1;176(9):5388-400.


TRAF2 deficiency results in hyperactivity of certain TNFR1 signals and impairment of CD40-mediated responses.

Nguyen LT, Duncan GS, Mirtsos C, Ng M, Speiser DE, Shahinian A, Marino MW, Mak TW, Ohashi PS, Yeh WC.

Immunity. 1999 Sep;11(3):379-89.

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