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Distinct domains of the protein tyrosine kinase tyk2 required for binding of interferon-alpha/beta and for signal transduction.

Velazquez L, Mogensen KE, Barbieri G, Fellous M, Uzé G, Pellegrini S.

J Biol Chem. 1995 Feb 17;270(7):3327-34.


Specific contribution of Tyk2 JH regions to the binding and the expression of the interferon alpha/beta receptor component IFNAR1.

Richter MF, Duménil G, Uzé G, Fellous M, Pellegrini S.

J Biol Chem. 1998 Sep 18;273(38):24723-9.


p135tyk2, an interferon-alpha-activated tyrosine kinase, is physically associated with an interferon-alpha receptor.

Colamonici OR, Uyttendaele H, Domanski P, Yan H, Krolewski JJ.

J Biol Chem. 1994 Feb 4;269(5):3518-22.


A dual role for the kinase-like domain of the tyrosine kinase Tyk2 in interferon-alpha signaling.

Yeh TC, Dondi E, Uze G, Pellegrini S.

Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):8991-6.


Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-gamma signal transduction pathway.

Watling D, Guschin D, Müller M, Silvennoinen O, Witthuhn BA, Quelle FW, Rogers NC, Schindler C, Stark GR, Ihle JN, et al.

Nature. 1993 Nov 11;366(6451):166-70.


Interferon-alpha-dependent activation of Tyk2 requires phosphorylation of positive regulatory tyrosines by another kinase.

Gauzzi MC, Velazquez L, McKendry R, Mogensen KE, Fellous M, Pellegrini S.

J Biol Chem. 1996 Aug 23;271(34):20494-500.


The SH2 domain-containing tyrosine phosphatase PTP1D is required for interferon alpha/beta-induced gene expression.

David M, Zhou G, Pine R, Dixon JE, Larner AC.

J Biol Chem. 1996 Jul 5;271(27):15862-5.


The amino-terminal region of Tyk2 sustains the level of interferon alpha receptor 1, a component of the interferon alpha/beta receptor.

Gauzzi MC, Barbieri G, Richter MF, Uzé G, Ling L, Fellous M, Pellegrini S.

Proc Natl Acad Sci U S A. 1997 Oct 28;94(22):11839-44.


Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase.

Colamonici O, Yan H, Domanski P, Handa R, Smalley D, Mullersman J, Witte M, Krishnan K, Krolewski J.

Mol Cell Biol. 1994 Dec;14(12):8133-42.


Role of STAT2 in the alpha interferon signaling pathway.

Leung S, Qureshi SA, Kerr IM, Darnell JE Jr, Stark GR.

Mol Cell Biol. 1995 Mar;15(3):1312-7.


Down-modulation of type 1 interferon responses by receptor cross-competition for a shared Jak kinase.

Dondi E, Pattyn E, Lutfalla G, Van Ostade X, Uzé G, Pellegrini S, Tavernier J.

J Biol Chem. 2001 Dec 14;276(50):47004-12. Epub 2001 Oct 15.


Induction of beta-R1/I-TAC by interferon-beta requires catalytically active TYK2.

Rani MR, Gauzzi C, Pellegrini S, Fish EN, Wei T, Ransohoff RM.

J Biol Chem. 1999 Jan 22;274(4):1891-7.


Interferon alpha (IFN alpha) signaling in cells expressing the variant form of the type I IFN receptor.

Colamonici OR, Domanski P, Krolewski JJ, Fu XY, Reich NC, Pfeffer LM, Sweet ME, Platanias LC.

J Biol Chem. 1994 Feb 25;269(8):5660-5.


Activation of the protein tyrosine kinase tyk2 by interferon alpha/beta.

Barbieri G, Velazquez L, Scrobogna M, Fellous M, Pellegrini S.

Eur J Biochem. 1994 Jul 15;223(2):427-35.


Homodimerization and intermolecular tyrosine phosphorylation of the Tyk-2 tyrosine kinase.

Domanski P, Yan H, Witte MM, Krolewski J, Colamonici OR.

FEBS Lett. 1995 Nov 6;374(3):317-22.


Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein.

Yan H, Krishnan K, Greenlund AC, Gupta S, Lim JT, Schreiber RD, Schindler CW, Krolewski JJ.

EMBO J. 1996 Mar 1;15(5):1064-74.


Activation of protein kinase A inhibits interferon induction of the Jak/Stat pathway in U266 cells.

David M, Petricoin E 3rd, Larner AC.

J Biol Chem. 1996 Mar 1;271(9):4585-8.

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