Similar articles for PMID: 7511100

Year	Number of Results
1991	1
1992	2
1993	3
1994	14
1995	15
1996	13
1997	11
1998	5
1999	7
2000	13
2001	5
2002	3
2003	3
2004	1
2005	2
2006	1
2008	1
2009	1
2015	1
2018	1
2021	1
2022	1
2024	0

1

Generation of interleukin-6 receptor antagonists by molecular-modeling guided mutagenesis of residues important for gp130 activation.

Savino R, Lahm A, Salvati AL, Ciapponi L, Sporeno E, Altamura S, Paonessa G, Toniatti C, Ciliberto G. Savino R, et al. EMBO J. 1994 Mar 15;13(6):1357-67. doi: 10.1002/j.1460-2075.1994.tb06389.x. EMBO J. 1994. PMID: 7511100 Free PMC article.

2

Molecular modeling-guided mutagenesis of the extracellular part of gp130 leads to the identification of contact sites in the interleukin-6 (IL-6).IL-6 receptor.gp130 complex.

Horsten U, Müller-Newen G, Gerhartz C, Wollmer A, Wijdenes J, Heinrich PC, Grötzinger J. Horsten U, et al. J Biol Chem. 1997 Sep 19;272(38):23748-57. doi: 10.1074/jbc.272.38.23748. J Biol Chem. 1997. PMID: 9295319 Free article.

3

Two distinct and independent sites on IL-6 trigger gp 130 dimer formation and signalling.

Paonessa G, Graziani R, De Serio A, Savino R, Ciapponi L, Lahm A, Salvati AL, Toniatti C, Ciliberto G. Paonessa G, et al. EMBO J. 1995 May 1;14(9):1942-51. doi: 10.1002/j.1460-2075.1995.tb07186.x. EMBO J. 1995. PMID: 7744001 Free PMC article.

4

Identification of single amino acid residues of human IL-6 involved in receptor binding and signal initiation.

Ehlers M, Grötzinger J, Fischer M, Bos HK, Brakenhoff JP, Rose-John S. Ehlers M, et al. J Interferon Cytokine Res. 1996 Aug;16(8):569-76. doi: 10.1089/jir.1996.16.569. J Interferon Cytokine Res. 1996. PMID: 8877726

5

Activation of the signal transducer glycoprotein 130 by both IL-6 and IL-11 requires two distinct binding epitopes.

Kurth I, Horsten U, Pflanz S, Dahmen H, Küster A, Grötzinger J, Heinrich PC, Müller-Newen G. Kurth I, et al. J Immunol. 1999 Feb 1;162(3):1480-7. J Immunol. 1999. PMID: 9973404

6

Identification of amino acid residues of gp130 signal transducer and gp80 alpha receptor subunit that are involved in ligand binding and signaling by human herpesvirus 8-encoded interleukin-6.

Li H, Nicholas J. Li H, et al. J Virol. 2002 Jun;76(11):5627-36. doi: 10.1128/jvi.76.11.5627-5636.2002. J Virol. 2002. PMID: 11991991 Free PMC article.

7

The molecular design of human IL-6 receptor antagonists.

Lahm A, Savino R, Salvati AL, Cabibbo A, Ciapponi L, Demartis A, Toniatti C, Paonessa G, Altamura S, Ciliberto G. Lahm A, et al. Ann N Y Acad Sci. 1995 Jul 21;762:136-50; discussion 150-1. doi: 10.1111/j.1749-6632.1995.tb32322.x. Ann N Y Acad Sci. 1995. PMID: 7668525 No abstract available.

8

Interleukin-6 (IL-6) antagonism by soluble IL-6 receptor alpha mutated in the predicted gp130-binding interface.

Salvati AL, Lahm A, Paonessa G, Ciliberto G, Toniatti C. Salvati AL, et al. J Biol Chem. 1995 May 19;270(20):12242-9. doi: 10.1074/jbc.270.20.12242. J Biol Chem. 1995. PMID: 7744875 Free article.

9

Combining two mutations of human interleukin-6 that affect gp130 activation results in a potent interleukin-6 receptor antagonist on human myeloma cells.

Ehlers M, de Hon FD, Bos HK, Horsten U, Kurapkat G, van De Leur HS, Grötzinger J, Wollmer A, Brakenhoff JP, Rose-John S. Ehlers M, et al. J Biol Chem. 1995 Apr 7;270(14):8158-63. doi: 10.1074/jbc.270.14.8158. J Biol Chem. 1995. PMID: 7713920 Free article.

10

Engineering human interleukin-6 to obtain variants with strongly enhanced bioactivity.

Toniatti C, Cabibbo A, Sporena E, Salvati AL, Cerretani M, Serafini S, Lahm A, Cortese R, Ciliberto G. Toniatti C, et al. EMBO J. 1996 Jun 3;15(11):2726-37. EMBO J. 1996. PMID: 8654370 Free PMC article.

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