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32078962,33316104,33930176,30509312,32914866,28275115,28416123,33523301,31446994,30734504,30885353,29658856,31319971,29433902,30577837,31290993,30589930,31432460,27718847,32926507,26984449,31856909,30586539,31549270,31237152,32663833,31200833,32720019,31031204,29675747,30825132,30515719,28806116,34791815,31319742,31446020,31375454,28818019,29191606,28499515,31030326,34802879,31326706,30391014,31053172,31238988,31686247,30678553,29317551,36748406,32601742,30337270,31097082,30620668,30188231,31262921,29145737,29129441,31066582,27583876,32937178,28318951,31182061,30836031,32150489,30053670,34767024,31655368,25400254,30429032,31654203,34543477,32462958,30019319,34149702,31164319,31130450,32450594,28534248,31297962,27252413,29156447,30113497,28434399,30548240,29318609,30201790,27265743,32077891,26858122,32339922,29463302,31693178,27026676,31138727,34019086,30595194,34156285,29115057,31738117,31365588,29910652,28620848,30207786,29409610,30100403,33434603,31786476,30819829,31353840,31529107,31015312,31902695,30712477,29140105,30355264,29746230,31432705,29573217,30885550,30105871,31703637,32843385,30893146,30018132,34434192,32462298,35816668,32474752,27480166,35101883,30969033,30642550,30268469,30612418,29931587,30541754,28064556,28960263,28554108,33710764,32986224,15161987,28739315,31238808,30912805,36725772,31995619,30846179,30879776,34545685,34663250,31506751,33119182,30646794,30345301,29573843,30032838,31701630,31130676,30285770,30911841,31880807,30808583,33813419,32674216,35101885,30409774,30311424,34607210,31990617,31761899,30693623,33533279,30562710,33565499,35311347,37147977,31686799,32769013,33517292,32646546,33566148,33044117,32954856,32027620,32425081,32151195,31026576,30682533,33186185,31607699,32164651,32213298,29785577,31460972,33074323,33130956,32500171,33070259,31196371,31640925,33847617,31311716,32599984,31828967,32199466,32646604,31209697,33448648,32315071,33790087,32400223,33450361,30913364,32141617,31196374,34216247,34825576,32446182,33058504,33084943,33108686,31348245,30664989,32055013,30827742,31729430,33017026,32140986,32753702,30591549,31728860,31319988,35124713,34750245,33240259,31852114,31745593,31669518,31542865,32877435,31745135,34135884,30244487,30568021,30736857,31494530,33892408,32327177,27540850,30777131,33046621,31512526,30711649,34678907,32661824,31036771,31721446,33577729,34398032,32462250,36621905,32379397,35499294,32783090,31937494,31021392,29982279,31713453,34500218,36950599,30316010,32111798,33910277,34131807,31911324,28749907,31988594,31117034,30104030,32180046,36250532,31573752,35058326,33709428,31815565,30101402,34307144,33084525,32299768,21424607,31829747,31145232,34214067,32953506,30476576,35863963,33660798,31449889,30628185,35586668,32152703,31120392,32234921,34593446,34268872,33759637,33753247,34237736,32116068,33849133,31221037,30383701,27523606,32150668,32575944,34295326,32921017,32091646,33983556,36933320,32058173,31143921,30792455,30554335,34470722,31236847,34128893,36308296,30943864,29915891,31622114,33687763,33626218,33737641,32930126,33878954,28761384,33839365,31328416,32522567,36905770,30461210,31165589,30880446,32591861,33039958,31182249,32583235,32129104,34042323,28529902,32770608,31896512,32559143,33821431,32436027,30647082,32357806,31683093,33150733,32520141,34108179,30297458,33673470,31096532,30765392,31863604,30074503,33125784,31409616,33896153,31535160,31195357,33719827,31444618,32025867,29908324,30105218,36825025,30980420,30409824,33779768,30910574,32446852,31449902,31254252,35994596,34504494,30923820,28428947,30869543,31327642,34833470,33781737,36341410,31456503,32757454,31014445,31930528,30790009,33894493,32776600,30950194,32541476,31642136,32757302,30972962,32064977,26942588,32769920,32354943,34759817,32178474,23934510,34655228,31415404,36153496,33040676,34047193,32094063,33545805,32674209,20351329,32771858,32595179,31470128,32327178,31548826,30990565,30635258,29540345,26576187,24684873,31903954,29181191,33355496,31259762,30950836,31699508,33865350,34747149,34001680,31085042,33308041,32686615,32462248,35031491,30232703,31675272,30552160,32554616,27313464,32503595,31781314,32284250,32879421,33605089,32266275,34114477,34643064,32269191,31248647,31043837,31277704,34250409,33015734,32034529,32620211,32245391,32049290,33171686,34942439,33612078,35704436,33622569,31132740,32980443,27468123,32161221,31532516,31155995,33256309,30935099,32011207,32671983,33648347,34093837,33859637,30760066,32936316,32679702,33729216,33325265,33478191,31204194,31601524,31145230,32616557,30862448,30742122,30407284,29593888,27386489,30984621,31300270,34538865,32065969,32043828,35838354,35577503,33922038,31442817,33263865,31400270,33583005,31455681,30648631,33215306,31882503,32989552,31446999,34764951,30173128,34256897,32162801,34521373,37150133,34645484,31440238,32852602,34390488,32620063,32930148,30683297,30529903,30301729,31030994,32441679,30965212,30837075,31116072,29209522,30614126,30285856,31335166,31944570,32635291,31200359,31423946,31436031,33624409,35595158,31026210,31322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Results by year

Year	Number of Results
2004	2
2010	1
2011	2
2012	3
2013	2
2014	11
2015	5
2016	31
2017	63
2018	140
2019	346
2020	364
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2022	170
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Toxicity management with combination chemotherapy and programmed death 1/programmed death ligand 1 inhibitor therapy in advanced lung cancer.

Hoffner B, Leighl NB, Davies M. Hoffner B, et al. Cancer Treat Rev. 2020 Apr;85:101979. doi: 10.1016/j.ctrv.2020.101979. Epub 2020 Feb 4. Cancer Treat Rev. 2020. PMID: 32078962 Review.

Single or combined immune checkpoint inhibitors compared to first-line platinum-based chemotherapy with or without bevacizumab for people with advanced non-small cell lung cancer.

Ferrara R, Imbimbo M, Malouf R, Paget-Bailly S, Calais F, Marchal C, Westeel V. Ferrara R, et al. Cochrane Database Syst Rev. 2020 Dec 14;12(12):CD013257. doi: 10.1002/14651858.CD013257.pub2. Cochrane Database Syst Rev. 2020. PMID: 33316104 Free PMC article. Updated.

Single or combined immune checkpoint inhibitors compared to first-line platinum-based chemotherapy with or without bevacizumab for people with advanced non-small cell lung cancer.

Ferrara R, Imbimbo M, Malouf R, Paget-Bailly S, Calais F, Marchal C, Westeel V. Ferrara R, et al. Cochrane Database Syst Rev. 2021 Apr 30;4(4):CD013257. doi: 10.1002/14651858.CD013257.pub3. Cochrane Database Syst Rev. 2021. PMID: 33930176 Free PMC article.

Which is the optimal immunotherapy for advanced squamous non-small-cell lung cancer in combination with chemotherapy: anti-PD-1 or anti-PD-L1?

Zhang Y, Zhou H, Zhang L. Zhang Y, et al. J Immunother Cancer. 2018 Dec 3;6(1):135. doi: 10.1186/s40425-018-0427-6. J Immunother Cancer. 2018. PMID: 30509312 Free PMC article. Clinical Trial.

Pembrolizumab plus chemotherapy versus chemotherapy alone in patients with advanced non-small cell lung cancer without tumor PD-L1 expression: A pooled analysis of 3 randomized controlled trials.

Borghaei H, Langer CJ, Paz-Ares L, Rodríguez-Abreu D, Halmos B, Garassino MC, Houghton B, Kurata T, Cheng Y, Lin J, Pietanza MC, Piperdi B, Gadgeel SM. Borghaei H, et al. Cancer. 2020 Nov 15;126(22):4867-4877. doi: 10.1002/cncr.33142. Epub 2020 Sep 11. Cancer. 2020. PMID: 32914866 Free PMC article.

Safety and Tolerability of PD-1/PD-L1 Inhibitors Compared with Chemotherapy in Patients with Advanced Cancer: A Meta-Analysis.

Nishijima TF, Shachar SS, Nyrop KA, Muss HB. Nishijima TF, et al. Oncologist. 2017 Apr;22(4):470-479. doi: 10.1634/theoncologist.2016-0419. Epub 2017 Mar 8. Oncologist. 2017. PMID: 28275115 Free PMC article. Review.

Immune Checkpoint Inhibitors for Patients With Advanced Non-Small-Cell Lung Cancer: A Systematic Review.

Ellis PM, Vella ET, Ung YC. Ellis PM, et al. Clin Lung Cancer. 2017 Sep;18(5):444-459.e1. doi: 10.1016/j.cllc.2017.02.001. Epub 2017 Feb 16. Clin Lung Cancer. 2017. PMID: 28416123 Review.

Real-world outcomes of anti-PD1 antibodies in platinum-refractory, PD-L1-positive recurrent and/or metastatic non-small cell lung cancer, and its potential practical predictors: first report from Korean Cancer Study Group LU19-05.

Park JH, You GL, Ahn MJ, Kim SW, Hong MH, Han JY, Ock CY, Lee JS, Oh IJ, Lee SY, Kim CH, Min YJ, Choi YH, Ryu JS, Park SH, Ahn HK, Shim BY, Lee KH, Lee SY, Kim JS, Yi J, Choi SK, An H, Kang JH. Park JH, et al. J Cancer Res Clin Oncol. 2021 Aug;147(8):2459-2469. doi: 10.1007/s00432-021-03527-4. Epub 2021 Feb 1. J Cancer Res Clin Oncol. 2021. PMID: 33523301

Safety and efficacy of pembrolizumab monotherapy in elderly patients with PD-L1-positive advanced non-small-cell lung cancer: Pooled analysis from the KEYNOTE-010, KEYNOTE-024, and KEYNOTE-042 studies.

Nosaki K, Saka H, Hosomi Y, Baas P, de Castro G Jr, Reck M, Wu YL, Brahmer JR, Felip E, Sawada T, Noguchi K, Han SR, Piperdi B, Kush DA, Lopes G. Nosaki K, et al. Lung Cancer. 2019 Sep;135:188-195. doi: 10.1016/j.lungcan.2019.07.004. Epub 2019 Jul 8. Lung Cancer. 2019. PMID: 31446994

Comparative efficacy and safety of first-line treatments for advanced non-small cell lung cancer with immune checkpoint inhibitors: A systematic review and meta-analysis.

Chen R, Hou X, Yang L, Zhao D. Chen R, et al. Thorac Cancer. 2019 Apr;10(4):607-623. doi: 10.1111/1759-7714.12971. Epub 2019 Feb 7. Thorac Cancer. 2019. PMID: 30734504 Free PMC article.

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