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Items: 1 to 20 of 99

1.

Targeting N-Terminal Huntingtin with a Dual-sgRNA Strategy by CRISPR/Cas9.

Wu J, Tang Y, Zhang CL.

Biomed Res Int. 2019 Nov 16;2019:1039623. doi: 10.1155/2019/1039623. eCollection 2019.

2.

Precise Excision of the CAG Tract from the Huntingtin Gene by Cas9 Nickases.

Dabrowska M, Juzwa W, Krzyzosiak WJ, Olejniczak M.

Front Neurosci. 2018 Feb 26;12:75. doi: 10.3389/fnins.2018.00075. eCollection 2018.

4.

N-terminal Huntingtin Knock-In Mice: Implications of Removing the N-terminal Region of Huntingtin for Therapy.

Liu X, Wang CE, Hong Y, Zhao T, Wang G, Gaertig MA, Sun M, Li S, Li XJ.

PLoS Genet. 2016 May 20;12(5):e1006083. doi: 10.1371/journal.pgen.1006083. eCollection 2016 May.

5.

Optimization of trans-Splicing for Huntington's Disease RNA Therapy.

Rindt H, Tom CM, Lorson CL, Mattis VB.

Front Neurosci. 2017 Oct 10;11:544. doi: 10.3389/fnins.2017.00544. eCollection 2017.

6.

CRISPR-Cas9-Mediated Genome Editing Increases Lifespan and Improves Motor Deficits in a Huntington's Disease Mouse Model.

Ekman FK, Ojala DS, Adil MM, Lopez PA, Schaffer DV, Gaj T.

Mol Ther Nucleic Acids. 2019 Sep 6;17:829-839. doi: 10.1016/j.omtn.2019.07.009. Epub 2019 Jul 26.

8.

Aggregation landscapes of Huntingtin exon 1 protein fragments and the critical repeat length for the onset of Huntington's disease.

Chen M, Wolynes PG.

Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):4406-4411. doi: 10.1073/pnas.1702237114. Epub 2017 Apr 11.

9.

Replacement of huntingtin exon 1 by trans-splicing.

Rindt H, Yen PF, Thebeau CN, Peterson TS, Weisman GA, Lorson CL.

Cell Mol Life Sci. 2012 Dec;69(24):4191-204. doi: 10.1007/s00018-012-1083-5. Epub 2012 Jul 20.

10.

The P42 peptide and Peptide-based therapies for Huntington's disease.

Marelli C, Maschat F.

Orphanet J Rare Dis. 2016 Mar 17;11:24. doi: 10.1186/s13023-016-0405-3. Review.

11.

Gene Therapy for Huntington's Disease Using Targeted Endonucleases.

Dabrowska M, Olejniczak M.

Methods Mol Biol. 2020;2056:269-284. doi: 10.1007/978-1-4939-9784-8_17.

PMID:
31586354
12.

Aberrantly spliced HTT, a new player in Huntington's disease pathogenesis.

Gipson TA, Neueder A, Wexler NS, Bates GP, Housman D.

RNA Biol. 2013 Nov;10(11):1647-52. doi: 10.4161/rna.26706. Epub 2013 Oct 11.

13.

CRISPR-Cas9 Mediated Gene-Silencing of the Mutant Huntingtin Gene in an In Vitro Model of Huntington's Disease.

Kolli N, Lu M, Maiti P, Rossignol J, Dunbar GL.

Int J Mol Sci. 2017 Apr 2;18(4). pii: E754. doi: 10.3390/ijms18040754.

14.

Effects of overexpression of huntingtin proteins on mitochondrial integrity.

Wang H, Lim PJ, Karbowski M, Monteiro MJ.

Hum Mol Genet. 2009 Feb 15;18(4):737-52. doi: 10.1093/hmg/ddn404. Epub 2008 Nov 27.

15.

HSP90 recognizes the N-terminus of huntingtin involved in regulation of huntingtin aggregation by USP19.

He WT, Xue W, Gao YG, Hong JY, Yue HW, Jiang LL, Hu HY.

Sci Rep. 2017 Nov 1;7(1):14797. doi: 10.1038/s41598-017-13711-7.

16.

Fluorescence Imaging of Huntingtin mRNA Knockdown.

Oh E, Liu Y, Sonar MV, Merry DE, Wickstrom E.

Bioconjug Chem. 2018 Apr 18;29(4):1276-1282. doi: 10.1021/acs.bioconjchem.8b00048. Epub 2018 Feb 26.

PMID:
29451775
17.

Permanent inactivation of Huntington's disease mutation by personalized allele-specific CRISPR/Cas9.

Shin JW, Kim KH, Chao MJ, Atwal RS, Gillis T, MacDonald ME, Gusella JF, Lee JM.

Hum Mol Genet. 2016 Oct 15;25(20):4566-4576. doi: 10.1093/hmg/ddw286.

18.

Phenotype onset in Huntington's disease knock-in mice is correlated with the incomplete splicing of the mutant huntingtin gene.

Franich NR, Hickey MA, Zhu C, Osborne GF, Ali N, Chu T, Bove NH, Lemesre V, Lerner RP, Zeitlin SO, Howland D, Neueder A, Landles C, Bates GP, Chesselet MF.

J Neurosci Res. 2019 Dec;97(12):1590-1605. doi: 10.1002/jnr.24493. Epub 2019 Jul 7.

19.

N-Terminal Fragments of Huntingtin Longer than Residue 170 form Visible Aggregates Independently to Polyglutamine Expansion.

Chen MZ, Mok SA, Ormsby AR, Muchowski PJ, Hatters DM.

J Huntingtons Dis. 2017;6(1):79-91. doi: 10.3233/JHD-160207.

PMID:
28339398
20.

Polyglutamine Tract Expansion Increases S-Nitrosylation of Huntingtin and Ataxin-1.

Ni CL, Seth D, Fonseca FV, Wang L, Xiao TS, Gruber P, Sy MS, Stamler JS, Tartakoff AM.

PLoS One. 2016 Sep 22;11(9):e0163359. doi: 10.1371/journal.pone.0163359. eCollection 2016.

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